TRAF5 Monoclonal Antibody (Clone 55A219) Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Tumor necrosis factor (TNF)-
induced signaling is mediated through association of TNF receptor (TNFR) with adaptor proteins, such as TNF receptor-
associated factors (TRAFs). TRAFs form a family of cytoplasmic adapter proteins that mediate signal transduction from many members of the TNF-
receptor superfamily (
e.g., RANK, CD30, CD40, etc.) and the interleukin-
1 receptor. The carboxy-
terminal region of TRAFs is required for self-
association and interaction with receptor cytoplasmic domains following ligand-
induced oligomerization. Recent molecular cloning studies have led to identification of seven TRAFs (TRAF1-
TRAF7). Human TRAF5 is a 557-
amino acid protein. TRAF5 is implicated in NF-
kB and c-
Jun NH(2)-
terminal kinase/stress-
activated protein kinase activation by members of the TNF receptor superfamily, including CD27, CD30, CD40, and lymphotoxin-
β receptor. Targeted disruption of TRAF5 gene causes defects in CD40-
CD27 mediated lymphocyte activation.
TRAF5 Monoclonal Antibody (Clone 55A219) Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
