Wortmannin-Rapamycin Conjugate

1067892-47-0

CAS-Nr.: 1067892-47-0

Englisch Name:: Wortmannin-Rapamycin Conjugate

Synonyma:: ATASUAOFUAOSAN-NVEIXTJJSA-N;Wortmannin-Rapamycin Conjugate;Rapamycin, 42-[8-[(1E,4S,4aR,5R,6aS,7S,9aR)-5-(acetyloxy)-1-[[[3-(dimethylamino)propyl]methylamino]methylene]-1,2,4,4a,5,6,6a,7,8,9,9a,10-dodecahydro-11-hydroxy-4-(methoxymethyl)-4a,6a-dimethyl-2,10-dioxocyclopenta[5,6]naphtho[1,2-c]pyran-7-yl] octanedioate]

CBNumber:: CB42592877

Summenformel:: C88H131N3O23

Molgewicht:: 1598.99

MOL-Datei:: 1067892-47-0.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 14

Wortmannin-Rapamycin Conjugate Eigenschaften

storage temp.: Store at -20°C

Löslichkeit: DMF: 30 mg/ml; DMSO: 20 mg/ml; Ethanol: 5 mg/ml

Aggregatzustand: A crystalline solid

Sicherheit

Wortmannin-Rapamycin Conjugate Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Phosphoinositide 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) act synergistically in promoting cancer. Wortmannin is a potent inhibitor of PI3K enzymes, while rapamycin blocks mTOR Complex 1 TORC1. Wortmannin-rapamycin conjugate consists of analogs of 17-hydroxy wortmannin and rapamycin conjugated via a prodrug linker. Hydrolysis of the prodrug linker in vivo releases the inhibitors. The wortmannin-rapamycin conjugate inhibits the growth of HT-29 colon tumors and A498 renal tumors in mice better than rapamycin alone. Also, the conjugate, when given in combination with the VEGF-blocker bevacizumab, produces substantial regression of larger A498 tumors. Finally, the wortmannin-rapamycin conjugate is tolerated better than an equivalent mixture of the inhibitors.

Wortmannin-Rapamycin Conjugate Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Wortmannin-Rapamycin Conjugate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 14)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32072	58
BOC Sciences	16314854226	info@bocsci.com	United States	9923	65
Shanghai Hongye Biotechnology Co. Ltd	400-9205774	sales@glpbio.cn	China	6777	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11217	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24648	58
Shanghai Yifei Biotechnology Co. , Ltd.	021-65675885 18964387627	customer_service@efebio.com	China	11974	58

Wortmannin-Rapamycin Conjugate
ATASUAOFUAOSAN-NVEIXTJJSA-N
Rapamycin, 42-[8-[(1E,4S,4aR,5R,6aS,7S,9aR)-5-(acetyloxy)-1-[[[3-(dimethylamino)propyl]methylamino]methylene]-1,2,4,4a,5,6,6a,7,8,9,9a,10-dodecahydro-11-hydroxy-4-(methoxymethyl)-4a,6a-dimethyl-2,10-dioxocyclopenta[5,6]naphtho[1,2-c]pyran-7-yl] octanedioate]
1067892-47-0
C88H131N3O23