1-(5-Chloro-2-hydroxyphenyl)-ethanone 2-(2,4,6-trichlorophenyl)hydrazone
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- CAS-Nr.
- 219315-22-7
- Englisch Name:
- 1-(5-Chloro-2-hydroxyphenyl)-ethanone 2-(2,4,6-trichlorophenyl)hydrazone
- Synonyma:
- Mitochondrial Fusion Promoter M1;Mitochondrial Fusion Promoter M1 >=95% (HPLC);Mitochondrial fusion promoter M1, 10 mM in DMSO;Mitochondrial Fusion Promoter, M1 - CAS 219315-22-7 - Calbiochem;(E)-4-Chloro-2-(1-(2-(2,4,6-trichlorophenyl)hydrazono)ethyl)phenol;1-(5-Chloro-2-hydroxyphenyl)ethanone (2,4,6-trichlorophenyl)hydrazone;1-(5-Chloro-2-hydroxyphenyl)-ethanone 2-(2,4,6-trichlorophenyl)hydrazone;Ethanone, 1-(5-chloro-2-hydroxyphenyl)-, 2-(2,4,6-trichlorophenyl)hydrazone;Mitochondrial Metabolism,ischemia,cardiac,inhibit,brain,damage,injury,reperfusion,Mitochondrial fusion promoter M 1,Mitochondrial fusion promoter M-1,Mitochondrial fusion promoter M1,Inhibitor
- CBNumber:
- CB42750677
- Summenformel:
- C14H10Cl4N2O
- Molgewicht:
- 364.05
- MOL-Datei:
- 219315-22-7.mol
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1-(5-Chloro-2-hydroxyphenyl)-ethanone 2-(2,4,6-trichlorophenyl)hydrazone Eigenschaften
- Siedepunkt:
- 464.769±55.00 °C(Press: 760.00 Torr)(predicted)
- Dichte
- 1.492±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
- storage temp.
- 2-8°C
- Löslichkeit
- DMSO: soluble10mg/mL, clear
- Aggregatzustand
- powder
- pka
- 7.857±0.48(predicted)
- Farbe
- white to beige
- Stabilität:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
- InChIKey
- WMAGOVJOXMBLHY-UHFFFAOYSA-N
- SMILES
- Clc1c(c(cc(c1)Cl)Cl)NNC(=C)c2c(ccc(c2)Cl)O
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| WGK Germany |
3 |
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| HS Code |
2928009090 |
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| Speicherklasse |
11 - Combustible Solids |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
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P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
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P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizität (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen. |
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1-(5-Chloro-2-hydroxyphenyl)-ethanone 2-(2,4,6-trichlorophenyl)hydrazone Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Mitochondrial Fusion Promoter M1 has been used as a fusion promoter:
- to study its effects on peroxisome proliferator-activated receptor-γ coactivator (PGC)-1α expression in breast cancer cells
- to study the link between nucleoside diphosphate kinase 3 (NME3)-regulated mitochondrial fluctuations and stability of genome in NME3 knockdown cells
- to study its effects on mitochondrial fusion in neuronal cells
Allgemeine Beschreibung
A cell-permeable phenylhydrazone compound that restores mitochondrial tubular network formation from the fragmented mitochondria seen in MEF lacking either one of the two outer mitochondrial membrane (OMM) mitofusins (EC
50 = 5.3 and 4.42 μM, respectively, in Mfn1 or Mfn2 knockout MEF cells) or MPP+-treated SH-SY5Y cells (5 μM 24 h), while displaying no effect on ER or lysosome morphology in Mfn1 knockout MEF. The effect of M1 is limited to enhancing weakened mitochondrial fusion machinery and M1 cannot by itself rebuild interconnected tubular mitochondria in MEF lacking both Mfn1/2 or the inner mitochondrial membrane (IMM) fusion mediator Opa1 (optic atrophy1). M1 (5 μM 24 h) is reported to boost the downregulated ATP5A and ATP5B protein level in either Mfn1 or Mfn2 knockout MEF to the wild-type MEF level and ATPase inhibitor oligomycin (Cat. No.
495455) at 5 μM is shown to completely offset the mitochondrial fusion effect by 5 μM M1 in Mfn1 knockout MEF. Both M1 and Z-VAD-FMK (Cat. No.
219007) are shown to protect SH-SY5Y against MPP
+-induced neuronal toxicity and additive protection can be achieved via a combined treatment (62%, 73%, 77%, and 89% survival rate, respectively, with DMSO, 5 μM M1, 1 μM Z-VAD-FMK, and combined treatment). Comparing to mdivi-1 (Cat. No.
475856), M1 exerts its effect via promoting fusion rather than inhibiting fission or division.
Biochem/physiol Actions
Cell permeable: yes
1-(5-Chloro-2-hydroxyphenyl)-ethanone 2-(2,4,6-trichlorophenyl)hydrazone Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
1-(5-Chloro-2-hydroxyphenyl)-ethanone 2-(2,4,6-trichlorophenyl)hydrazone Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 51)Lieferanten
219315-22-7()Verwandte Suche:
- (E)-4-Chloro-2-(1-(2-(2,4,6-trichlorophenyl)hydrazono)ethyl)phenol
- 1-(5-Chloro-2-hydroxyphenyl)-ethanone 2-(2,4,6-trichlorophenyl)hydrazone
- Mitochondrial Fusion Promoter M1
- Mitochondrial Fusion Promoter, M1 - CAS 219315-22-7 - Calbiochem
- Ethanone, 1-(5-chloro-2-hydroxyphenyl)-, 2-(2,4,6-trichlorophenyl)hydrazone
- Mitochondrial Fusion Promoter M1 >=95% (HPLC)
- Mitochondrial Metabolism,ischemia,cardiac,inhibit,brain,damage,injury,reperfusion,Mitochondrial fusion promoter M 1,Mitochondrial fusion promoter M-1,Mitochondrial fusion promoter M1,Inhibitor
- 1-(5-Chloro-2-hydroxyphenyl)ethanone (2,4,6-trichlorophenyl)hydrazone
- Mitochondrial fusion promoter M1, 10 mM in DMSO
- 219315-22-7
