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2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE

2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE Struktur
76081-98-6
CAS-Nr.
76081-98-6
Englisch Name:
2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE
Synonyma:
S28080;SCH 28080;SCH-28080,SCH28080;Schering compound 28080;imidazo-(1-2-a)pyrine-3-acetonitrile;2-Methyl-8-(phenylmethoxy)imidazo-(1-2-A)pyrine-3-acetonitrile;2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE;2-(8-(Benzyloxy)-2-methylimidazo[1,2-a]pyridin-3-yl)acetonitrile;Imidazo(1,2-A)pyridine-3-acetonitrile, 2-methyl-8-(phenylmethoxy)-;3-(CYANOMETHYL)-2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-ALPHA]PYRIDINE
CBNumber:
CB4281209
Summenformel:
C17H15N3O
Molgewicht:
277.32
MOL-Datei:
76081-98-6.mol
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2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE Eigenschaften

Dichte
1.16±0.1 g/cm3(Predicted)
storage temp. 
-20°C
Löslichkeit
DMSO: >10 mg/mL, soluble
Aggregatzustand
solid
pka
5.85±0.10(Predicted)
Farbe
white to light tan

Sicherheit

S-Sätze: 22-24/25
WGK Germany  3

2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:

S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.

Beschreibung

SCH 28080 is a reversible K+-competitive inhibitor of H+/K+-ATPases that is best known for its ability to block acid secretion through its action against the gastric H+/K+-ATPase (IC50 = 1.3 μM). It is effective against gastric H+/K+-ATPases from a variety of species and can inhibit colonic H+/K+-ATPases, but this activity appears to be species-dependent. SCH 28080 is also used to investigate the role of H+/K+-ATPases in non-mammalian organisms and to distinguish the actions of H+/K+-ATPases from other ATP-dependent transporters.

Verwenden

SCH 28080 is a potent inhibitor of H+,K+-ATPase.

Biologische Aktivität

Potent inhibitor of H + ,K + -ATPase (IC 50 = 20 nM); binds to the K + recognition site and is competitive with respect to K + . Inhibits gastric acid secretion in vitro and in vivo .

2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 58)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 32165 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525
 masar@topule.com China 8467 58
Aladdin Scientific 		+1-+1(833)-552-7181
sales@aladdinsci.com United States 57505 58
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037
 3bsc@sina.com China 15839 69
Sigma-Aldrich 021-61415566 800-8193336
 orderCN@merckgroup.com China 51456 80
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266
 China 4512 55
EMMX Biotechnology LLC 888-539-0666
info@emmx.com United States 8447 60
Shanghai Chaolan Chemical Technology Center 021-QQ：65489617 15618227136
 Sales@ATKchemical.com China 7268 58
BOC Sciences --
 info@bocsci.com USA 0 65
DC Chemicals 021-58447131 13564518121
 sales@dcchemicals.com China 9409 58
  • 3-(CYANOMETHYL)-2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-ALPHA]PYRIDINE
  • 2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE
  • 2-Methyl-8-(phenylmethoxy)imidazo-(1-2-A)pyrine-3-acetonitrile
  • Imidazo(1,2-A)pyridine-3-acetonitrile, 2-methyl-8-(phenylmethoxy)-
  • S28080
  • Schering compound 28080
  • SCH 28080
  • imidazo-(1-2-a)pyrine-3-acetonitrile
  • SCH-28080,SCH28080
  • 2-(8-(Benzyloxy)-2-methylimidazo[1,2-a]pyridin-3-yl)acetonitrile
  • 76081-98-6
  • Ion Pump Inhibitors
  • Ion Channels
  • Monovalent Ion Channels
  • Voltage-gated Ion Channels
  • BioChemical
  • Cell Signaling and Neuroscience
  • Cell Biology
  • ATPase
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