trans-4-[[(2-Amino-3,5-dibromphenyl)methyl]amino]cyclohexan-1-olhydrochlorid
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- CAS-Nr.
- 23828-92-4
- Bezeichnung:
- trans-4-[[(2-Amino-3,5-dibromphenyl)methyl]amino]cyclohexan-1-olhydrochlorid
- Englisch Name:
- Ambroxol hydrochloride
- Synonyma:
- AMBROXOL HCL;Antobron;MUCOSOLVAN;Ambroxol HCI;Ambroxol Hydrochlorid;AMBRIL;Ambron;Ankisol;FLUIXOL;ABRAMEN
- CBNumber:
- CB4304139
- Summenformel:
- C13H19Br2ClN2O
- Molgewicht:
- 414.56
- MOL-Datei:
- 23828-92-4.mol
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trans-4-[[(2-Amino-3,5-dibromphenyl)methyl]amino]cyclohexan-1-olhydrochlorid Eigenschaften
- Schmelzpunkt:
- 233-234.5°C
- storage temp.
- Inert atmosphere,2-8°C
- Löslichkeit
- Sparingly soluble in water, soluble in methanol, practically insoluble in methylene chloride.
- Aggregatzustand
- Solid
- Farbe
- White to Off-White
- PH
- pH(10g/l, 25℃) : 4.0～6.0
- Wasserlöslichkeit
- Slightly soluble in water (~5 mg/ml) or ethanol (~5 mg/ml).
- Merck
- 14,386
- InChI
- InChI=1/C13H18Br2N2O.ClH/c14-9-5-8(13(16)12(15)6-9)7-17-10-1-3-11(18)4-2-10;/h5-6,10-11,17-18H,1-4,7,16H2;1H/t10-,11-;
- InChIKey
- QNVKOSLOVOTXKF-PFWPSKEQSA-N
- SMILES
- [C@@H]1(O)CC[C@@H](NCC2=CC(Br)=CC(Br)=C2N)CC1.[H]Cl |&1:0,4,r|
- CAS Datenbank
- 23828-92-4(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Kennzeichnung gefährlicher |
Xn |
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| R-Sätze: |
22 |
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| S-Sätze: |
36 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
GV8423000 |
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| HS Code |
29221980 |
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| Toxizität |
LD50 in mice, rats (mg/kg): 268, 380 i.p.; 2720, 13400 orally (Püschmann, Engelhorn) |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizität (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen. |
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trans-4-[[(2-Amino-3,5-dibromphenyl)methyl]amino]cyclohexan-1-olhydrochlorid Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
S-Sätze Betriebsanweisung:
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
White Crystalline Powder
Definition
ChEBI: Ambroxol hydrochloride is an aromatic amine. it is a metabolite of bromhexine that stimulates mucociliary action and clears the air passages in the respiratory tract. it is usually administered as the hydrochloride.
Indications
Ambroxol Hydrochloride is a bronchosecretolytic drug. It is indicated as “secretolytic therapy in bronchopulmonary diseases associated with abnormal mucus secretion and impaired mucus transport. It promotes mucus clearance, facilitates expectoration and eases productive cough, allowing patients to breathe freely and deeply.
Biologische Aktivität
Sodium channel blocker and mucolytic agent with antioxidant, anti-viral and anti-inflammatory properties. Inhibits tetrodotoxin (TTX)-resistant channels more potently than TTX-sensitive subtypes (IC 50 values for tonic block are 35.2 and 111.5 μ M respectively). Inhibits release of histamine, leukotrienes and cytokines from human leukocytes and mast cells.
Mode of action
Ambroxol is the active metabolite of bromhexine. Ambroxol causes an increase in secretion in the respiratory tract. It promotes surfactant production and stimulates ciliary activity. These effects assist the flow of mucus and its removal (mucociliary clearance). An improvement in mucociliary clearance was demonstrated in clinical pharmacological studies. The increase in secretion and mucociliary clearance facilitate expectoration and reduce the cough. In in vitro studies ambroxol showed a significant reduction in cytokine release, both in the blood and in mononuclear and polynuclear cells. The clinical relevance of these findings is unclear.
trans-4-[[(2-Amino-3,5-dibromphenyl)methyl]amino]cyclohexan-1-olhydrochlorid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
trans-4-[[(2-Amino-3,5-dibromphenyl)methyl]amino]cyclohexan-1-olhydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 629)Lieferanten
23828-92-4(trans-4-[[(2-Amino-3,5-dibromphenyl)methyl]amino]cyclohexan-1-olhydrochlorid)Verwandte Suche:
- Ankisol
- Ambroxol hydrochloride ,99%
- AMbroxol Hydrochloride BP/EP
- cis-4-((2-AMino-3,5-dibroMobenzyl)aMino)cyclohexanol hydrochloride
- Ambroxol Hydrochloride and Ge Injection
- AMBRIL
- 4-[[(2-AMINO-3,5-DIBROMOPHENYL)METHYL]AMINO]CYLCOPHEXANOL HYDROCHLORIDE
- 2-AMINO-3,5-DIBROMO-N-[TRANS-4-HYDROXYCYCLOHEXYL]BENZYLAMINE HYDROCHLORIDE
- TRANS-4-[[(2-AMINO-3,5-DIBROMOPHENYL)METHYL]AMINO]CYCLOHEXANOL MONOHYDROCHLORIDE
- TRANS-4-((2-AMINO-3,5-DIBROMOBENZYL)AMINO)CYCLOHEXANOL, HCL
- trans-4-[[(2-amino-3,5-dibromo-phenyl)methyl]amino]-cyclohexanol hydrochloride
- 4-(((2-amino-3,5-dibromophenyl)methyl)amino)-cyclohexanomonohydrochlorid
- 4-((2-amino-3,5-dibromobenzyl)amino)-,hydrochloride,trans-cyclohexano
- 5-dibromobenzyl)amino)-4-(n-(2-amino-hydrochloride(e)-cyclohexano
- mucolear
- na872hydrochloride
- Cyclohexanol, 4-[[(2-amino-3,5-dibromophenyl)methyl]amino]-, hydrochloride (1:1), trans-
- Ambroxol hydro
- trans-4-[[(2-amino-3,5-dibromophenyl)methyl]amino]cyclohexan-1-ol hydrochloride
- DURAMUCAL
- LABOTEST-BB LT00134650
- FLUIXOL
- FRENOPECT
- BLUIBRON
- BRONCHOPRONT
- ABRAMEN
- AMBROXOL HYDROCHLORIDE
- trans-4-((2-amino-3,5-dibromobenzyl)amino)cyclohexanolhydrochloride
- 4-[[(2-Amino-3,5-dibromophenyl)methyl]amino]cycophexanol Hydrochloride, Abramen, Ambril, Bronchopront, Duramucal, Bluibron, Fluixol, Frenopect
- Mucoangin
- N-(trans-p-Hydroxycyclohexyl)-(2-amino-3,5-dibromobenzyl)amine hydrochloride
- Ambron
- Ambroxol chloridate
- Ambroxol hydrochloride DURAMUCAL FLUIXOLFRENOPECTBLUIBRONBRONCHOPRONTABRAMENAMBROXOL HCLambroxolcis-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol
- (1r,4r)-4-((2-amino-3,5-dibromobenzyl)amino)
- yansuananxisuo
- (1r,4r)-4-((2-amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride
- Ambroxol (monohydrochloride)
- CAS 23828-92-4ambroxol Hydrochloride
- (2-amino-3,5-dibromophenyl)methyl-(4-hydroxycyclohexyl)ammonium
- Ambroxol hydrochloride CRS
- AmbroxolHydrochloride>
- Ambroxil Base
- Ambroxol hydrochloride USP/EP/BP
- 4-[[(2-Amino-3,5-dibromophenyl)methyl]amino]cycophexanol Hydrochloride
- Ambroxol HCl (NA-872)
- RAC-TRANS-AMBROXOL-D5 HYDROCHLORIDE
- Ambroxol hydrochloride 13C7D
- Ambroxol hydrochlorideQ: What is
Ambroxol hydrochloride Q: What is the CAS Number of
Ambroxol hydrochloride Q: What is the storage condition of
Ambroxol hydrochloride Q: What are the applications of
Ambroxol hydrochloride
- Antobron
- MUCOSOLVAN
- AMBROXOL HCL
- Ambroxol HCI
- Ambroxol Hydrochlorid
- Ambroxol Hydrochloride (As per EP)
- AMBROXOL HCl IP
- Ambroxol hydrochloridum
- N-Nitroso Ambroxol-15N
