MS37452

423748-02-1

CAS-Nr.: 423748-02-1

Englisch Name:: MS37452

Synonyma:: MS37452;1-(2,3-dimethoxybenzoyl)-4-[(3-methylphenoxy)acetyl]piperazine;1-(4-(2,3-Dimethoxybenzoyl)piperazin-1-yl)-2-(m-tolyloxy)ethanone;1-[4-(2,3-Dimethoxybenzoyl)-1-piperazinyl]-2-(3-methylphenoxy)-ethanone;Ethanone, 1-[4-(2,3-dimethoxybenzoyl)-1-piperazinyl]-2-(3-methylphenoxy)-;MS 37452,Histone Methyltransferase,transcription,Inhibitor,MS37452,p16/CDKN2A,anticancer,H3K27me3,derepress,CBX7 chromodomain,inhibit,INK4A/ARF,MS-37452

CBNumber:: CB43060612

Summenformel:: C22H26N2O5

Molgewicht:: 398.45224

MOL-Datei:: 423748-02-1.mol

Request For Quotation

Eigenschaften Sicherheit Verwendungswort Produktionsfirma 45

MS37452 Eigenschaften

Siedepunkt:: 628.8±55.0 °C(Predicted)

Dichte: 1.209±0.06 g/cm3(Predicted)

storage temp.: -20°C

Löslichkeit: ≤30mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide

pka: -1.31±0.70(Predicted)

Aggregatzustand: powder

Farbe: white to beige

Sicherheit

MS37452 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Chromobox homolog 7 (CBX7) functions through its N-terminal chromodomain, which recognizes histone 3 trimethyl lysine 27 (H3K27me3), to repress gene transcription. It plays a key role in gene transcription in cellular processes related to stem cell self-renewal and differentiation, as well as tumor progression. MS37452 is a competitive inhibitor of CBX7 chromodomain binding to H3K27me3 (K_i = 43 μM). At 250 μM, it has been shown to derepress transcription of the polycomb repressive complex target gene p16/CDKN2A in prostate cancer cells.

Verwenden

MS37452 is a competitive inhibitor of CBX7 chromodomain binding to H3K27me3 and has been shown to derepress transcription of the polycomb repressive complex target gene.

Biochem/physiol Actions

MS37452 is a selective Chromobox homolog 7 (CBX7) modulator that disrupts CBX7ChD binding to H3K27me3. MS37452 inhibits CBX7 binding to INK4/ARF gene locus, and induces decline of p14/ARF and p16/INK4a in human PC3 cells.

MS37452 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

MS37452 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 45)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4252	55
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9707	58
Shanghai Changyan Chem & Tech Co., Ltd.	021-021-20242659 18930833303	order@changyanchem.com	China	5009	55
Beijing OKA biological technology co., LTD	010-010-62971590 18548936886	3462612863@qq.com	China	6912	58
DC Chemicals	021-58447131 13564518121	sales@dcchemicals.com	China	9412	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11289	58
Absin Bioscience Inc.	021-38015121 15000105423	chenjw@absin.cn	China	24734	58
MedBioPharmaceutical Technology Inc	021-69568360 18916172912	order@med-bio.cn	China	8141	58

MS37452
1-(2,3-dimethoxybenzoyl)-4-[(3-methylphenoxy)acetyl]piperazine
Ethanone, 1-[4-(2,3-dimethoxybenzoyl)-1-piperazinyl]-2-(3-methylphenoxy)-
1-(4-(2,3-Dimethoxybenzoyl)piperazin-1-yl)-2-(m-tolyloxy)ethanone
1-[4-(2,3-Dimethoxybenzoyl)-1-piperazinyl]-2-(3-methylphenoxy)-ethanone
MS 37452,Histone Methyltransferase,transcription,Inhibitor,MS37452,p16/CDKN2A,anticancer,H3K27me3,derepress,CBX7 chromodomain,inhibit,INK4A/ARF,MS-37452
423748-02-1