3-Methylcholanthren Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R45:Kann Krebs erzeugen.
R36:Reizt die Augen.
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R11:Leichtentzündlich.
S-Sätze Betriebsanweisung:
S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S16:Von Zündquellen fernhalten - Nicht rauchen.
Beschreibung
3-Methylcholanthrene (3-MC) is a member of the polycyclic
aromatic hydrocarbon (PAH) family and is used as an experimental
cancer research chemical. As other PAHs, 3-MC might be
found in trace quantities in coal tar and heavy-end petroleum
hydrocarbons.
Chemische Eigenschaften
3-Methylcholanthrene is a solid that crystallizes from benzene
and ether as pale yellow prisms. 3-methylcholanthrene
is insoluble in water and
soluble in alcohol. It is combustible, and can react with
oxidizing materials.
Verwenden
3-Methylcholanthrene has been used to assess its tumor initiation activity by Bhas 42 cell transformation assay. It has also been used to induce the activity of cytochrome P450.
Definition
ChEBI: A pentacyclic ortho- and peri-fused polycyclic arene consisting of a dihydrocyclopenta[ij]tetraphene ring system with a methyl substituent at the 3-position.
Allgemeine Beschreibung
Yellow crystals or solid.
Air & Water Reaktionen
Insoluble in water.
Reaktivität anzeigen
3-METHYLCHOLANTHRENE can react with oxidizing materials. Ozone and chlorinating agents oxidize 3-METHYLCHOLANTHRENE.
Hazard
Powerful carcinogen.
Brandgefahr
Flash point data for 3-METHYLCHOLANTHRENE are not available; however, 3-METHYLCHOLANTHRENE is probably combustible.
Sicherheitsprofil
Suspected carcinogen
with experimental carcinogenic,
neoplastigenic, and tumorigenic data. Poison
by intravenous and intraperitoneal routes.
Experimental teratogenic and reproductive
effects. Human mutation data reported.
When heated to decomposition it emits
acrid smoke and irritating fumes.
mögliche Exposition
The coke-oven plant is the principal source of coal tar. The hot gases and vapors produced during the conversion of coal to coke are collected by means of a scrubber, which condenses the effluent into ammonia, water, crude tar, and other by-products. Crude tar is separated from the remainder of the condensate for refining and may undergo further processing. Employees may be exposed to pitch and creosote in metal and foundry operations; when installing electrical equipment; in construction, railway, utility; and briquette manufacturing.
Carcinogenicity
3-Methylcholanthrene is a rapid,
all-around neoplastic agent and a potent liver
tumorigen.
Environmental Fate
3-MC, when released to soil, adsorbs strongly to the soil and
does not leach. It does not biodegrade or hydrolyze significantly
but may evaporate from dry soil. If released to water, it is
expected to adsorb strongly to sediment and to bioconcentrate
in aquatic organisms. If released into the atmosphere, it may be
subject to direct photolysis because it absorbs strongly in the
ultraviolet (UV) spectrum of light. It may also react with peroxyl
radicals already present in the atmosphere. Its estimated
half-life in the atmosphere is 2.8 h. Considering an octanol/
water log concentration ratio of 6.42, a bioconcentration factor
of 45 000 has been estimated.
Versand/Shipping
UN1136 Coal tar distillates, flammable, Hazard Class: 3; Labels: 3-Flammable liquid
Inkompatibilitäten
Incompatible with strong oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Phenols, such as creosote react as weak organic acids. Phenols and cresols are much weaker as acids than common carboxylic acids (phenol has pKa = 9.88). These materials are incompatible with strong reducing agents such as hydrides, nitrides, alkali metals, and sulfides. Flammable hydrogen gas is often generated, and the heat of the reaction may ignite the gas. Heat is also generated by the acid-base reaction between phenols and bases. Such heating may initiate polymerization of the organic compound. Phenols are sulfonated very readily (e.g., by concentrated sulfuric acid at room temperature). The reactions generate heat. Phenols are also nitrated very rapidly, even by dilute nitric acid
Waste disposal
Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed.
3-Methylcholanthren Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
