HUMAN TNF-ALPHA
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- CAS-Nr.
- 94948-59-1
- Englisch Name:
- HUMAN TNF-ALPHA
- Synonyma:
- hTNF-α;CACHECTIN;HUMAN DIF;TNF ALPHA;Tasonermin;HTNF-ALPHA;TNF, HUMAN;HUMAN TNF-A;RHTNF-ALPHA;HUMAN TNFSF2
- CBNumber:
- CB4704832
- Summenformel:
- NULL
- Molgewicht:
- 0
- MOL-Datei:
- Mol file
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HUMAN TNF-ALPHA Eigenschaften
- storage temp.
- -20°C
- Aggregatzustand
- powder
- Farbe
- colorless
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| WGK Germany |
3 |
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| RTECS-Nr. |
MT6435000 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H361 |
Kann vermutlich die Fruchtbarkeit beeinträchtigen oder das Kind im Mutterleib schädigen. |
Reproduktionstoxizität |
Kategorie 2 |
Warnung |
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P201, P202, P281, P308+P313, P405,P501 |
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| Sicherheit |
| P201 |
Vor Gebrauch besondere Anweisungen einholen. |
| P202 |
Vor Gebrauch alle Sicherheitshinweise lesen und verstehen. |
| P281 |
Vorgeschriebene persönliche Schutzausrüstung verwenden. |
| P308+P313 |
BEI Exposition oder falls betroffen: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen. |
| P405 |
Unter Verschluss aufbewahren. |
| P501 |
Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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HUMAN TNF-ALPHA Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Tasonermin was launched in Germany for the treatment of
soft tissue sarcoma of the limbs. Recent literature is scarce for this compound. It
is the first tumor necrosis factor (TNF) launched for cancer treatment to date and
works through destruction of tumor blood vessels. This recombinant protein is
expressed in E. coil and purified. Tasonermin is too toxic for systemic use and
consequently is being used in isolated limb perfusion (ILP) for sarcoma and
malignant melanoma. The product has shown notable efficacy when used in
combination with melphalan to prevent amputation. In four European clinical
trials involving 260 patients destined for amputation or mutilating surgery,
Beromun enabled durable limb salvage in 80% of the patients. Due to the
complexity of ILP, the application of tasonermin is restricted to clinical centers
with sufficient experience and facilities including radionucleide-based continuous
monitoring of leakage from the isolated circuit during ILP and postoperative
intensive care surveillance.
Verwenden
Tumor Necrosis Factor-a human has been used:
- as a permeability inducing agent for endothelial cell monolayer permeability assay
- as a reactive oxygen species inducer in primary rat cardiac microvascular endothelial cells (RCMVECs)
- in the activation of nuclear factor kappa B (NF-κB) in human embryonic kidney cells (HEK293), neuroblastoma SH-SY5Y cells and HeLa cells
- in the stimulation of the human keratinocyte cell line(HaCaT) and human coronary artery endothelial cells (HCAECs)
Allgemeine Beschreibung
The TNFα (tumor necrosis factor α) gene is mapped to human chromosome 6p21.33. TNFα is a member of TNF superfamily. TNF-α has a palmitoyl group in the cysteine residue and is phosphorylated in the transmembrane region serine residue.
HUMAN TNF-ALPHA Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
HUMAN TNF-ALPHA Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 20)Lieferanten
94948-59-1()Verwandte Suche:
2-Methylpropylisocyanid
(p-Toluolsulfonyl)methylisocyanid
Dichloro(ethylendiamin)platin
Tris(2,2,6,6-tetramethylheptan-3,5-dionato-O,O')dysprosium
Phenylselenol
Benzylisocyanid
Ethylisocyanacetat
Tris(pentan-2,4-dionato)eisen(II)
Kupfer(II)-4-oxopent-2-en-2-olat
N-Butylisocyanid
Methylisocyanacetat
(Ethylenbis(nitrilomethylidyn)-2,2'-diphenolato)cobalt(II)
1,1,3,3-Tetramethylbutylisocyanat
Aluminiumtris(2,4-pentandionato-O,O')
Tris(2,2,6,6-tetramethylheptan-3,5-dionato-O,O')europium
(Pentan-2,4-dionato-O,O')silber
- Tumor Necrosis Factor-α human,TNF-α, hTNF-α
- hTNF-α
- TNF-α, Human, Recombinant,
- CACHECTIN
- HUMAN TNF-A
- recombinanthumantumornecrosisfactoralpha
- TUMOR NECROSIS FACTOR-A, HUMAN*RECOMBINA NT, EXPRESS
- TUMOR NECROSIS FACTOR HUMAN RECOMBINANT PRODUCED IN
- Tasonermin
- tumor necrosis factor-α human
- TUMOR NECROSIS FACTOR(TNF)-ALPHA, HUMAN, RECOMBINANT
- Tumor Necrosis Factor-α Human recombinant
- HUMAN TNF-ALPHA (E COLI-DERIVED)
- HUMAN TUMOR NECROSIS FACTOR ALPHA
- HUMAN TNFSF2
- HUMAN NECROSIN
- HUMAN CACHECTIN
- HUMAN CYTOTOXIN
- HUMAN DIF
- HUMAN DIFFERENTIATION-INDUCING FACTOR
- HTNF-ALPHA
- EXTRACELLULAR DOMAIN (AA 85-233)
- humanrecombinanttumornecrosisfactor-alpha
- REC TUMOR NECROSIS FACTOR-ALPHA (HUMAN)
- REC TNF-A (HUMAN)
- REC TNF-ALPHA (HUMAN)
- RECOMBINANT HUMAN TNF-A
- RECOMBINANT HUMAN TNF-ALPHA (E COLI-DERIVED)
- RH-CACHECTIN
- RHSMEGA-TNF-ALPHA
- RHTNF-ALPHA
- TNFSF 2 (HUMAN)
- TNFSF 2, SOLUBLE (HUMAN)
- TNF ALPHA
- TNF-ALPHA HUMAN
- TNF-ALPHA, HUMAN E COLI, R-DNA
- TNF-ALPHA, SOLUBLE (HUMAN)
- TNF-ALPHA, SOLUBLE (HUMAN) (REC)
- TNF-ALPHA, SOLUBLE (HUMAN) (RECOMBINANT)
- TNF, HUMAN
- TUMOR NECROSIS FACTOR-ALPHA
- TUMOR NECROSIS FACTOR-ALPHA, SOLUBLE (HUMAN)
- TUMOR NECROSIS FACTOR-ALPHA, HUMAN
- TUMOR NECROSIS FACTOR, ALPHA-, HUMAN E COLI, R-DNA
- TUMOR NECROSIS FACTOR-ALPHA, HUMAN, RECOMBINANT
- TUMOR NECROSIS FACTOR(TNF)-ALPHA, HUMAN
- HUMAN TNF-ALPHA
- TNF-α, Human, Recombinant, E. coli
- N-Propyl-N-[2-(2,4,6-trichlorophenoxy)ethyl]-1H-imidazole-1-carbo xamide - 2,4,7-trinitro-9H-fluoren-9-one (1:1)
- Tumor Necrosis Factor-α, human
- tumor necrosis factor human recombinant produced
- rec TNF-α (human)
- 94948-59-1
- C28H21Cl3N6O9
- BioChemical
- Cell Biology
- Cell Signaling and Neuroscience
- Cytokines, Growth Factors and Hormones
