KNK437

218924-25-5

CAS-Nr.: 218924-25-5

Englisch Name:: KNK437

Synonyma:: KNK437;KNK423;CS-1681;KNK-437;KNK 437;HEAT SHOCK PROTEIN INHIBITOR I;HEAT SHOCK PROTEIN INHIBITOR II;KNK 437 (Heat Shock Protein Inhibitor I);3,4-METHYLENEDIOXY-BENZYLIDINE-GAMMA-BUTYROLACTAM;N-Formyl-3,4-methylenedioxy-benzylidene-g-butyrolactam;N-FORMYL-3,4-METHYLENEDIOXY-BENZYLIDINE-GAMMA-BUTYROLACTAM

CBNumber:: CB4713272

Summenformel:: C13H11NO4

Molgewicht:: 245.23

MOL-Datei:: Mol file

Request For Quotation

Eigenschaften Sicherheit Verwendungswort Produktionsfirma 81

KNK437 Eigenschaften

Siedepunkt:: 412.4±55.0 °C(Predicted)

Dichte: 1.515±0.06 g/cm3(Predicted)

storage temp.: room temp

Löslichkeit: DMSO: soluble5mg/mL, clear (warmed)

Aggregatzustand: White to light yellow powder

pka: -1.70±0.20(Predicted)

Farbe: white to beige

Stabilität:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Sicherheit

WGK Germany	3

KNK437 Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

KNK437 has been used:

as a heat shock factor 1 (HSF1) inhibitor to study its effects on the inhibition of viability and apoptosis activation in chemoresistant mice cells
as an HSF1 inhibitor to study its effects on viability and apoptosis of colorectal cancer cells
as a heat shock protein 70 (HSP70) inhibitor to study its effects on glutamine-induced HSP70 and inflammatory mediator release

Biochem/physiol Actions

KNK437 inhibits the accumulation of heat shock proteins (including hsp -27, -40, -70, -72 and -105). KNK437 inhibits thermotolerance in cells with greater potency than quercetin.

KNK437 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

KNK437 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 81)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32956	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29880	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	sales@chemdad.com	China	39894	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	+86-021-61551413 +8618813727289	contact@trustwe.com	China	5738	58
Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd	+86-86-22-87899925 +86-8618522618860	18522618860@163.com	China	694	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32161	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20283	58

218924-25-5()Verwandte Suche:

Dechaliniumchlorid

N-FORMYL-3,4-METHYLENEDIOXY-BENZYLIDINE-GAMMA-BUTYROLACTAM
3,4-METHYLENEDIOXY-BENZYLIDINE-GAMMA-BUTYROLACTAM
KNK423
KNK437
HEAT SHOCK PROTEIN INHIBITOR I
HEAT SHOCK PROTEIN INHIBITOR II
3-(1,3-Benzodioxol-5-ylmethylene)-2-oxo-1-pyrrolidinecarboxaldehyde
Heat Shock Protein Inhibitor I - CAS 218924-25-5 - Calbiochem
CS-1681
3-[(E)-1,3-Benzodioxol-5-ylmethylene]-2-oxopyrrolidine-1-carbaldehyde
KNK-437;KNK 437
1-Pyrrolidinecarboxaldehyde, 3-(1,3-benzodioxol-5-ylmethylene)-2-oxo-
N-Formyl-3,4-methylenedioxy-benzylidene-g-butyrolactam
3-(Benzo[d][1,3]dioxol-5-ylmethylene)-2-oxopyrrolidine-1-carbaldehyde
HSP,inhibit,Heat shock proteins,KNK-437,KNK437,KNK 437,Inhibitor
KNK 437 (Heat Shock Protein Inhibitor I)
KNK 437 (Heat Shock Protein Inhibitor I), heat shock protein biosynthesis inhibitor
218924-25-5
API
Inhibitors