BISINDOLYLMALEIMIDE III

137592-43-9

CAS-Nr.: 137592-43-9

Englisch Name:: BISINDOLYLMALEIMIDE III

Synonyma:: BISINDOLYLMALEIMIDE III;3-[1-(3-aminopropyl)indol-3-yl]-4-(1H-indol-3-yl)pyrrole-2,5-dione;3-(1-(3-Aminopropyl)-1H-indol-3-yl)-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione;1H-Pyrrole-2,5-dione, 3-[1-(3-aminopropyl)-1H-indol-3-yl]-4-(1H-indol-3-yl)-

CBNumber:: CB4728487

Summenformel:: C23H20N4O2

Molgewicht:: 384.43

MOL-Datei:: Mol file

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 25

BISINDOLYLMALEIMIDE III Eigenschaften

Siedepunkt:: 708.7±60.0 °C(Predicted)

Dichte: 1.41±0.1 g/cm3(Predicted)

Löslichkeit: DMSO: soluble; Methanol: soluble

Aggregatzustand: A crystalline solid

pka: 8.15±0.60(Predicted)

Farbe: Brown to reddish brown

Sicherheit

BISINDOLYLMALEIMIDE III Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Bisindolylmaleimide III was developed as a protein kinase C (PKC) inhibitor with structural similarity to the nonspecific PKC inhibitor staurosporine. At 1 μM, bisindolylmaleimide III inhibits 93% of PKCα kinase activity and also inhibits many other protein kinases including, S6K1, MAPKAP-K1, RSK2 and MSK1 with similar potency. Additionally, it inhibits PDK1, an important kinase in the insulin signaling pathway, with an IC₅₀ value of 3.8 μM.

Verwenden

Bisindolylmaleimide III is a protein kinase C inhibitor and was also shown to exhibit inhibitory activities towards PDK1, an important kinase in the insulin signaling pathway,

BISINDOLYLMALEIMIDE III Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

BISINDOLYLMALEIMIDE III Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 25)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57511	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52927	58
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	96815	76
Shanghai TaoSu Biochemical Technology Co., Ltd.	021-33632979	info@tsbiochem.com	China	8073	58
BOC Sciences	16314854226	info@bocsci.com	United States	9926	65
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9708	58
Tianjin Kailiqi Biotechnology Co., Ltd.	15076683720	klq@cw-bio.com	China	3717	55
Shenzhen Polymeri Biochemical Technology Co., Ltd.	+86-400-002-6226 13028896684	sales@rrkchem.com	China	56057	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11289	58
Bide Pharmatech Ltd.	400-1647117 15221909166	product02@bidepharm.com	China	63720	58

BISINDOLYLMALEIMIDE III
3-[1-(3-aminopropyl)indol-3-yl]-4-(1H-indol-3-yl)pyrrole-2,5-dione
1H-Pyrrole-2,5-dione, 3-[1-(3-aminopropyl)-1H-indol-3-yl]-4-(1H-indol-3-yl)-
3-(1-(3-Aminopropyl)-1H-indol-3-yl)-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione
137592-43-9
Amines, Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals