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3-hydroxy-1-methyl-5-pyridin-3-yl-pyrrolidin-2-one

3-hydroxy-1-methyl-5-pyridin-3-yl-pyrrolidin-2-one Struktur
34834-67-8
CAS-Nr.
34834-67-8
Englisch Name:
3-hydroxy-1-methyl-5-pyridin-3-yl-pyrrolidin-2-one
Synonyma:
Ccris 7628;Hydroxycotinine;trans-3’-Hydroxycotini;trans-3'-Hydroxy Cotinine;-Hydroxycotinine (cis-3’trans-3’-Hydroxycotinine solution;(3'R,5'S)-trans-3'-Hydroxynicotinine;trans-3'-Hydroxy Cotinine (1.0 Mg/ML in Methanol);3-hydroxy-1-methyl-5-pyridin-3-yl-pyrrolidin-2-one;3-Hydroxy-1-methyl-5-(3-pyridinyl)-2-pyrrolidinone
CBNumber:
CB51236009
Summenformel:
C10H12N2O2
Molgewicht:
192.21
MOL-Datei:
34834-67-8.mol
Request For Quotation

3-hydroxy-1-methyl-5-pyridin-3-yl-pyrrolidin-2-one Eigenschaften

Schmelzpunkt:
107-109°C
Siedepunkt:
416.5±45.0 °C(Predicted)
Dichte
1.275±0.06 g/cm3(Predicted)
Flammpunkt:
9℃
storage temp. 
Hygroscopic, -20°C Freezer, Under Inert Atmosphere
Löslichkeit
DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 10 mg/ml
Aggregatzustand
A crystalline solid
pka
13.02±0.40(Predicted)
Farbe
White to off-white
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher F,T
R-Sätze: 11-23/24/25-39/23/24/25
S-Sätze: 16-36/37-45
RIDADR  UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany  1
Bildanzeige (GHS) GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H225 Flüssigkeit und Dampf leicht entzündbar. Entzündbare Flüssigkeiten Kategorie 2 Achtung GHS hazard pictogramssrc="/GHS02.jpg" width="20" height="20" /> P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H370 Schädigt die Organe. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 1 Achtung GHS hazard pictogramssrc="/GHS08.jpg" width="20" height="20" /> P260, P264, P270, P307+P311, P321,P405, P501
Sicherheit
P210 Von Hitze, heißen Oberflächen, Funken, offenen Flammen und anderen Zündquellenarten fernhalten. Nicht rauchen.
P260 Dampf/Aerosol/Nebel nicht einatmen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P301+P310 BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P311 GIFTINFORMATIONSZENTRUM/Arzt anrufen.

3-hydroxy-1-methyl-5-pyridin-3-yl-pyrrolidin-2-one Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

trans-3’-Hydroxycotinine (3HC) is a product of CYP2A6 metabolism of the primary nicotine metabolite, cotinine . Cotinine has a longer metabolic half-life compared to 3HC (16 hours vs. 5 hours). The ratio of 3HC to cotinine, termed the nicotine metabolite ratio, correlates with nicotine clearance from the body and is used as a biomarker of CYP2A6 activity. This measure of nicotine metabolism has been used to study tobacco and secondhand smoke exposure as well as to develop pharmacological intervention strategies for smoking cessation.

Chemische Eigenschaften

Off-White to Pale-Yellow Solid

Verwenden

A metabolite of Nicotine. Carcinogen.

Definition

ChEBI: An N-alkylpyrrolidine that is cotinine substituted at position C-3 by a hydroxy group (the 3R,5S-diastereomer).

Allgemeine Beschreibung

Trans-3′-Hydroxycotinine is a major nicotine metabolite excreted in the urine of smokers and users of other tobacco or nicotine products including cigars, chewing tobacco and snuff. This Certified Spiking Solution? is suitable for use in nicotine testing methods or clinical and diagnostic testing of nicotine biomarkers by LC-MS/MS or GC/MS.

3-hydroxy-1-methyl-5-pyridin-3-yl-pyrrolidin-2-one Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

3-hydroxy-1-methyl-5-pyridin-3-yl-pyrrolidin-2-one Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 34)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hubei Jusheng Technology Co.,Ltd. 		18871490254
linda@hubeijusheng.com CHINA 28172 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 32161 58
Guangzhou CATO Research Chemicals Inc. 		+86-020-81960175-617 +8615602392859
 Intermediate@cato-chem.com China 8046 58
J & K SCIENTIFIC LTD. 010-82848833 400-666-7788
 jkinfo@jkchemical.com China 96815 76
Chemsky（shanghai）International Co.,Ltd. 021-50135380
shchemsky@sina.com China 32321 50
Shanghai TaoSu Biochemical Technology Co., Ltd. 021-33632979
info@tsbiochem.com China 8065 58
Cato Research Chemicals Inc. 020-81960175
min.he@cato-chem.com China 1955 55
Sigma-Aldrich 021-61415566 800-8193336
 orderCN@merckgroup.com China 51456 80
BOC Sciences 16314854226
 info@bocsci.com United States 9923 65
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627
 info@efebio.com China 9806 58

34834-67-8()Verwandte Suche:

Sulfanilamid
  • 3-hydroxy-1-methyl-5-pyridin-3-yl-pyrrolidin-2-one
  • Hydroxycotinine
  • (3R,5S)-1-Methyl-3-hydroxy-5-(3-pyridyl)pyrrolidine-2-one
  • (3R,5S)-3-Hydroxy-1-methyl-5-(3-pyridinyl)pyrrolidin-2-one
  • (3'R,5'S)-trans-3'-Hydroxynicotinine
  • 3-Hydroxy-1-methyl-5-(3-pyridinyl)-2-pyrrolidinone
  • Ccris 7628
  • (3R,5S)-3-Hydroxy-1-Methyl-5-(3-pyridinyl)-2-pyrrolidinone
  • trans-3'-Hydroxy Cotinine (1.0 Mg/ML in Methanol)
  • trans-3’-Hydroxycotinine solution
  • -Hydroxycotinine (cis-3&rsquo
  • 2-Pyrrolidinone, 3-hydroxy-1-methyl-5-(3-pyridinyl)-, (3R,5S)-
  • (+)-TRANS-3'-HYDROXYCOTININE UNLABELED 100 UG/ML IN ACETONITRILE
  • trans-3’-Hydroxycotini
  • trans-3'-Hydroxy Cotinine
  • 34834-67-8
  • Chiral Reagents, Heterocycles, Metabolites & Impurities, Nicotine Derivatives, Mutagenesis Research Chemicals
  • Chiral Reagents
  • Heterocycles
  • Metabolites & Impurities
  • Mutagenesis Research Chemicals
  • Nicotine Derivatives
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