Anti-S.cerevisiae homolog of RAD24, Anti-hRad17 Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Anti-RAD17 (N-terminal) antibody produced in rabbit has been used in immunoblotting and immunoprecipitation.
Allgemeine Beschreibung
Cell cycle checkpoint protein RAD17 is mapped to human chromosome 5q13.2 . It is also called s a replication factor C (RFC)-like DNA damage sensor protein. Eight alternative spliced transcript variants of the gene, which encode four distinct proteins, have been reported.
Biochem/physiol Actions
RAD17 has been reported in breast, non-small cell lung carcinoma and breast cancer. RAD17 is a critical event during checkpoint signaling in DNA-damaged cells. Treatment of human cells with genotoxic agents induced ATM/ATR dependent phosphorylation of RAD17 at Ser635 and Ser645 , suggesting that phosphorylation of RAD17 is a critical event during checkpoint signaling in DNA-damaged cells.
Anti-S.cerevisiae homolog of RAD24, Anti-hRad17 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
