GSK-3β Inhibitor XVIII

1139875-74-3

CAS-Nr.: 1139875-74-3

Englisch Name:: GSK-3β Inhibitor XVIII

Synonyma:: GSK3β-IN-1a;GSK3β-IN-1a;GSK-3β inhibitor 8;GSK3β Inhibitor XVIII;GSK-3β Inhibitor XVIII;GSK-3β Inhibitor XVIII - CAS 1139875-74-3 - Calbiochem;2-chloro-4-[[4-(2-thienyl)-2-pyrimidinyl]amino]phenyl](4-methyl-1-piperazinyl)-,methanone;Methanone, [2-chloro-4-[[4-(2-thienyl)-2-pyrimidinyl]amino]phenyl](4-methyl-1-piperazinyl)-

CBNumber:: CB52602508

Summenformel:: C20H20ClN5OS

Molgewicht:: 413.92

MOL-Datei:: 1139875-74-3.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 17

GSK-3β Inhibitor XVIII Eigenschaften

Siedepunkt:: 632.3±65.0 °C(Predicted)

Dichte: 1.358±0.06 g/cm3(Predicted)

storage temp.: +2C to +8C

Löslichkeit: DMSO: soluble

pka: 6?+-.0.10(Predicted)

Aggregatzustand: White solid

Farbe: White to off-white

Sicherheit

GSK-3β Inhibitor XVIII Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

GSK3β inhibitor XVIII is an inhibitor of glycogen synthase kinase 3β (GSK3β; IC₅₀ = 64 nM). It induces expression of a luciferase reporter in HEK293 cells expressing wild-type Wnt (EC₅₀ = ~1.25 μM) but not in cells expressing a β-catenin/TCF binding site-mutant Wnt. GSK3β inhibitor XVIII increases β-catenin accumulation in the nucleus of HEK293 cells. It induces proliferation of R7T1 β-cells (EC₅₀ = 1,143 nM), an effect that can be blocked by the COX and Wnt signaling inhibitor sulindac , and rat primary β-cells.

GSK-3β Inhibitor XVIII Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

GSK-3β Inhibitor XVIII Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 17)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
BOC Sciences	16314854226	info@bocsci.com	United States	9926	65
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9708	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11289	58
Jinan Jiuli Biotechnology Co. , Ltd.	14768611851	486064515@qq.com	China	2041	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24017	58
Nanjing Tengyi Biotechnology Co., Ltd	025-58851786 17714337195	sales@tybiochem.com	China	5595	58
Nantong Hanfang Biotechnology Co. , Ltd.	18616537568	hanfangpharma@126.com	China	30968	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	28118	58
Nanjing Shizhou Biology Technology Co.,Ltd	025-85560043 15850508050	cindy.huang@synzest.com	China	12007	58

1139875-74-3()Verwandte Suche:

6-Hydroxy-2,5,7,8-tetramethylchroman-2-carbonsure

GSK-3β Inhibitor XVIII
GSK-3β Inhibitor XVIII - CAS 1139875-74-3 - Calbiochem
GSK3β-IN-1a
GSK3β Inhibitor XVIII
Methanone, [2-chloro-4-[[4-(2-thienyl)-2-pyrimidinyl]amino]phenyl](4-methyl-1-piperazinyl)-
GSK3β-IN-1a
2-chloro-4-[[4-(2-thienyl)-2-pyrimidinyl]amino]phenyl](4-methyl-1-piperazinyl)-,methanone
GSK-3β inhibitor 8
1139875-74-3