ILIMAQUINONE

ILIMAQUINONE Struktur
71678-03-0
CAS-Nr.
71678-03-0
Englisch Name:
ILIMAQUINONE
Synonyma:
IQ;ILIMAQUINONE;illimaquinone;(-)-Ilimaquinine;(-)-ILIMAQUINONE;5-Epiilimaquinone;Ilimaquinone - CAS 71678-03-0 - Calbiochem;3-[(decahydro-1β,2β,4aβ-trimethyl-5-methylene-1-naphthyl)methyl]-2-hydroxy-5-methoxybenzoquinone;3-[(DECAHYDRO-1B,2B,4AB-TRIMETHYL-5-METHYLENE-1-NAPHTHYL)METHYL]-2-HYDROXY-5-METHOXYBENZOQUINONE;2-[[(1R,8aα)-1,2β,4aβ-Trimethyl-5-methylenedecalin-1α-yl]methyl]-3-hydroxy-6-methoxy-1,4-benzoquinone
CBNumber:
CB5267651
Summenformel:
C22H30O4
Molgewicht:
358.47
MOL-Datei:
71678-03-0.mol

ILIMAQUINONE Eigenschaften

Schmelzpunkt:
108-110℃ (pentane )
alpha 
D23 -23.2° (c = 1.12 in CHCl3)
Siedepunkt:
478.4±45.0 °C(Predicted)
Dichte
1.14±0.1 g/cm3(Predicted)
storage temp. 
−20°C
Löslichkeit
DMSO: Soluble; Ethanol: Soluble; Hexane: Soluble; Methanol: Soluble
pka
2.92±0.50(Predicted)
Aggregatzustand
Red solid
Farbe
Light yellow to brown

Sicherheit

WGK Germany  3

ILIMAQUINONE Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Ilimaquinone is a natural sesquiterpene quinone that has antimicrobial, anti-HIV, anti-mitotic, and anti-inflammatory properties. In mammalian cells, 25 μM ilimaquinone reversibly induces vesiculation of Golgi membranes, blocking the secretory pathway. It inhibits the conversion of S-adenosylhomocysteine (SAH) to homocysteine by SAH hydrolase (IC50 = 40 μM). Ilimaquinone also inhibits DNA polymerase β and dual specificity phosphatase Cdc25B (IC50 = 45.2 and 92 μM, respectively) and, at 10 μM, activates gene expression through hypoxia-inducible factor-1.

Verwenden

Ilimaquinone is an ADP-ribosylation factor (ARF) and β-COP to the Golgi membrane inhibitor.

Definition

ChEBI: A natural product found in Dactylospongia elegans.

Allgemeine Beschreibung

A cell-permeable marine sponge metabolite with anti-microbial, anti-HIV, anti-inflammatory, and anti-mitotic properties. Induces a complete and reversible breakdown of Golgi membranes into smaller vesicular structures and causes depolymerization of microtubules. Inhibits cellular methylations through its interaction with S-adenosylhomocysteinase. Blocks the cytotoxicity of ricin and diphtheria toxin. Acts as an inhibitor of the RNase H activity of HIV-1.

ILIMAQUINONE Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


ILIMAQUINONE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 59)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Aladdin Scientific
+1-+1(833)-552-7181
sales@aladdinsci.com United States 52927 58
Shanghai Tauto Biotech Co., Ltd. 021-51320588
tauto@tautobiotech.com China 3989 66
Hotechem Shanghai Co., Ltd., 021-34621078 13120882795
465106944@qq.com China 859 56
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627
info@efebio.com China 9708 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767
sales@chemegen.com China 11289 58
TargetMol Chemicals Inc. 15002134094
marketing@targetmol.cn China 28118 58

71678-03-0()Verwandte Suche:


  • 3-[(DECAHYDRO-1B,2B,4AB-TRIMETHYL-5-METHYLENE-1-NAPHTHYL)METHYL]-2-HYDROXY-5-METHOXYBENZOQUINONE
  • 3-[(DECAHYDRO-1BETA,2BETA,4A-BETA-TRIMETHYL-5-METHYLENE-1-NAPHTHYL)-METHYL]-2-HYDROXY-5-METHOXYBENZOQUINONE
  • 3-[(DECAHYDRO-1BETA,2BETA,4A-BETA-TRIMETHYL-5-METHYLENE-1-NAPTHYL)METHYL]-2-HYDROXY-5-METHOXYBENZOQUINONE
  • 3-[(DECAHYDRO-1BETA,2BETA,4ALPHA-BETA-TRIMETHYL-5-METHYLENE-1-NAPHTHYL)METHYL]-2-HYDROXY-5-METHOXYBENZOQUINONE
  • IQ
  • ILIMAQUINONE
  • 3-[(decahydro-1β,2β,4aβ-trimethyl-5-methylene-1-naphthyl)methyl]-2-hydroxy-5-methoxybenzoquinone
  • illimaquinone
  • 5-Epiilimaquinone
  • (-)-Ilimaquinine
  • 2-[[(1R,8aα)-1,2β,4aβ-Trimethyl-5-methylenedecalin-1α-yl]methyl]-3-hydroxy-6-methoxy-1,4-benzoquinone
  • 3-[[(1R,8aα)-Decahydro-1,2β,4aβ-trimethyl-5-methylenenaphthalene-1α-yl]methyl]-2-hydroxy-5-methoxy-2,5-cyclohexadiene-1,4-dione
  • 3-[[[(1R,8aα)-Decahydro-1,2β,4aβ-trimethyl-5-methylenenaphthalen]-1α-yl]methyl]-2-hydroxy-5-methoxy-2,5-cyclohexadiene-1,4-dione
  • 3-[[(1R,2S,4aS,8aS)-Decahydro-1,2,4a-trimethyl-5-methylene-1-naphthalenyl]methyl]-2-hydroxy-5-methoxy-2,5-cyclohexadiene-1,4-dione
  • (-)-ILIMAQUINONE
  • Ilimaquinone - CAS 71678-03-0 - Calbiochem
  • 2,5-CYCLOHEXADIENE-1,4-DIONE,3-[[(1R,2S,4AS,8AS)-DECAHYDRO-1,2,4A-TRIMETHYL-5-METHYLENE-1-NAPHTHALENYL] METHYL]-2-HYDROXY-5-METHOXY-
  • 71678-03-0
  • Cell Biology
  • Cell Signaling and Neuroscience
  • BioChemical
  • Organelle Proteins and Related Molecules
  • Cytoskeleton and Extracellular Matrix
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