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Dolutegravir Impurity 3

1973402-05-9

CAS-Nr.: 1973402-05-9

Englisch Name:: Dolutegravir Impurity 3

Synonyma:: Dotiravir Impurity 3;Dolutegravir Impurity 3;Dolutegravir impurity A;Dolutegravir Impurity 51;DolutegravirImpurity9SodiumSalt;(R)-N-(2,4-difluorobenzyl)-9-hydroxy-2-(4-hydroxybutan-2-yl)-1,8-dioxo-2,8-dihydro-1H-pyrido[1,2-a]p;(R)-N-(2,4-difluorobenzyl)-9-hydroxy-2-(4-hydroxybutan-2-yl)-1,8-dioxo-1,8-dihydro-2H-pyrido[1,2-a]pyrazine-7-carboxamide;N-[(2,4-Difluorophenyl)methyl]-1,8-dihydro-9-hydroxy-2-[(1R)-3-hydroxy-1-methylpropyl]-1,8-dioxo-2H-pyrido[1,2-a]pyrazine-7-carboxamide;2H-Pyrido[1,2-a]pyrazine-7-carboxamide, N-[(2,4-difluorophenyl)methyl]-1,8-dihydro-9-hydroxy-2-[(1R)-3-hydroxy-1-methylpropyl]-1,8-dioxo-;Dolutegravir impurity 2/2H-Pyrido[1,2-a]pyrazine-7-carboxamide, N-[(2,4-difluorophenyl)methyl]-1,8-dihydro-9-hydroxy-2-[(1R)-3-hydroxy-1-methylpropyl]-1,8-dioxo-

CBNumber:: CB53154305

Summenformel:: C20H19F2N3O5

Molgewicht:: 419.38

MOL-Datei:: 1973402-05-9.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 29

Dolutegravir Impurity 3 Eigenschaften

Schmelzpunkt:: 95-100°C

Siedepunkt:: 662.3±55.0 °C(Predicted)

Dichte: 1.51±0.1 g/cm3(Predicted)

storage temp.: -20°C Freezer, Under inert atmosphere

Löslichkeit: DMSO (Slightly), Methanol (Slightly)

Aggregatzustand: Solid

pka: 4.50±1.00(Predicted)

Farbe: Yellow

Sicherheit

Dolutegravir Impurity 3 Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

(R)-N-(2,4-Difluorobenzyl)-9-hydroxy-2-(4-hydroxybutan-2-yl)-1,8-dioxo-2,3,4,8-tetrahydro-1H-pyrido[1,2-a]pyrazine-7-carboxamide is impurity E of Dolutegravir (D528800), which is a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector.

Dolutegravir Impurity 3 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Dolutegravir Impurity 3 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 29)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14336	58
AFINE CHEMICALS LIMITED	+86-0571-85134551	info@afinechem.com	China	15395	58
China National Standard Pharmaceutical Corporation Limited	+8615391658522	overseasales@yongstandards.com	China	11927	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58
Aurisco Pharmaceutical (Tianjin) Inc.	022-59885855	liuyujie@aurisco.com	China	96	58
S.Z. PhyStandard Bio-Tech. Co., Ltd.	0755-4000505016 13380397412	3001272453@qq.com	China	4964	50
ChemStrong Scientific Co.,Ltd	0755-0755-66853366 13670046396	sales@chem-strong.com	China	18018	56
Shanghai Kewel Chemical Co., Ltd.	021-64609169 18901607656	greensnown@163.com	China	9911	50
Lynnchem	86-(0)29-85992781 17792393971	info@lynnchem.com	China	4587	58
Hubei Yangxin Medical Technology Co., Ltd.	15374522761	3003392093@qq.com	China	8046	55

Dolutegravir Impurity 3
(R)-N-(2,4-difluorobenzyl)-9-hydroxy-2-(4-hydroxybutan-2-yl)-1,8-dioxo-1,8-dihydro-2H-pyrido[1,2-a]pyrazine-7-carboxamide
(R)-N-(2,4-difluorobenzyl)-9-hydroxy-2-(4-hydroxybutan-2-yl)-1,8-dioxo-2,8-dihydro-1H-pyrido[1,2-a]p
Dolutegravir Impurity 51
N-[(2,4-Difluorophenyl)methyl]-1,8-dihydro-9-hydroxy-2-[(1R)-3-hydroxy-1-methylpropyl]-1,8-dioxo-2H-pyrido[1,2-a]pyrazine-7-carboxamide
Dolutegravir impurity A
2H-Pyrido[1,2-a]pyrazine-7-carboxamide, N-[(2,4-difluorophenyl)methyl]-1,8-dihydro-9-hydroxy-2-[(1R)-3-hydroxy-1-methylpropyl]-1,8-dioxo-
Dolutegravir impurity 2/2H-Pyrido[1,2-a]pyrazine-7-carboxamide, N-[(2,4-difluorophenyl)methyl]-1,8-dihydro-9-hydroxy-2-[(1R)-3-hydroxy-1-methylpropyl]-1,8-dioxo-
DolutegravirImpurity9SodiumSalt
Dotiravir Impurity 3
1973402-05-9