SB 431542

SB 431542 Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:

S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.

Beschreibung

SB-431542 is a potent and selective inhibitor of the TGF-β1 receptor ALK5 (IC₅₀ = 94 nM). It is a less potent antagonist of ALK4 (IC₅₀ = 140 nM) and ALK7. It does not affect the BMP receptors ALK2, ALK3, ALK6, or a panel of other kinases tested. SB-431542 specifically blocks Smad signaling, reducing gene expression relevant to fibrosis and cancer. Through its effects on ALK/Smad signaling, SB-431542 suppresses renewal in embryonic and induced pluripotent stem cells and promotes their differentiation.

Definition

ChEBI: A member of the class of benzamides that is 4-(imidazol-2-yl)benzamide carrying additional 1,3-benzodioxol-5-yl and pyridin-2-yl substituents at positions 4 and 5 respectively on the imidazole ring.

Allgemeine Beschreibung

A cell-permeable triarylimidazole compound that is shown to effectively inhibit cellular Smad2 phosphorylation (>90% inhibition by 10 μM inhibitor) upon vector-mediated expression of constitutively active ALK4, ALK5, or ALK7 in NIH 3T3 cells, while exhibiting little effect against Smad1 phosphorylation by other members of type I receptors for TGF-β in NIH 3T3 cultures expressing active ALK1, 2, 3, or 6. When tested directly in cell-free kinase assays, SB431542 is demonstrated to potently inhibit the activity of ALK4 and ALK5 (IC₅₀ = 140 nM and 94 nM, respectively) with no or much reduced potency toward a panel of 24 other kinases (IC₅₀ ≥10 μM in the presence of 10 μM ATP), including ALK2 and ALK6. Reported to improve the efficiency of 4-TF-induced human iPSCs generation from fibroblast cultures by >200-fold when used together with PD0325901 (Cat. No. 444966) and Thiazovivin (Cat. No. 420220).

Biologische Aktivität

Potent and selective inhibitor of the transforming growth factor- β (TGF- β ) type I receptor activin receptor-like kinase ALK5 (IC 50 = 94 nM), and its relatives ALK4 and ALK7. Suppresses TGF- β -induced proliferation of human osteosarcoma cells. Stimulates proliferation, differentiation and sheet formation of ESC-derived endothelial cells.

SB 431542 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

SB 431542 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29791	60
Hangzhou FandaChem Co.,Ltd.	+8615858145714	FandaChem@Gmail.com	China	9210	55
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3009	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32957	60
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	965	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49374	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32165	58
Dayang Chem (Hangzhou) Co.,Ltd.	571-88938639 +8617705817739	info@dycnchem.com	China	52849	58

301836-41-9()Verwandte Suche:

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• SB-431542/SB431542
• SB 431542, >=98%
• 4-[4-(3,4-Methylenedioxyphenyl)-5-(2-pyridyl)-1H-imidazol-2-yl]benzamide SB431542
• SB 431542 4-[4-(3,4-Methylenedioxyphenyl)-5-(2-pyridyl)-1H-imidazol-2-yl]benzamide
• 4-[4-(3,4-Methylenedioxyphenyl)-5-(2-pyridyl)-1H-imidazol-2-yl]-benzamide hydrate
• SB 431542
• 4-(5-BENZOL[1,3]DIOXOL-5-YL-4-PYRLDIN-2-YL-1H-IMIDAZOL-2-YL)-BENZAMIDE
• 4-[4-(3,4-METHYLENEDIOXYPHENYL)-5-(2-PYRIDYL)-1H-IMIDAZOL-2-YL]-BENZAMIDE
• 4-[4-(1,3-BENZODIOXOL-5-YL)-5-(2-PYRIDINYL)-1H-IMIDAZOL-2-YL]BENZAMIDE
• InSolution? TGF-β RI Kinase Inhibitor VI, SB431542
• TGF-β RI Kinase Inhibitor VI, SB431542
• SB 431542 HYDRATE
• Benzamide, 4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]-
• 4-(5-benzol[1,3]dioxol-5-yl-4-pyrldin-2-yl-1h-imidazol-2-yl)-benzamide hydrate
• 4-(5-Benzol[1,3]dioxol-5-yl-4-pyrldin-2-yl-1H-imidazol-2-yl)-benzamide hydrate, 4-[4-(3,4-Methylenedioxyphenyl)-5-(2-pyridyl)-1H-imidazol-2-yl]-benzamide hydrate, 4-[4-(1,3-Benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]-benzamide hydrate
• SB 431542 hydrate,4-(5-Benzol[1,3]dioxol-5-yl-4-pyrldin-2-yl-1H-imidazol-2-yl)-benzamide hydrate, 4-[4-(3,4-Methylenedioxyphenyl)-5-(2-pyridyl)-1H-imidazol-2-yl]-benzamide hydrate
• 4-[4-(1,3-Benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]-benzamide hydrate
• 4-(4-(benzo[d][1,3]dioxol-5-yl)-5-(pyridin-2-yl)-1H-imidazol-2-yl)benzamide
• 4-[4-(2H-1,3-benzodioxol-5-yl)-5-(pyridin-2-yl)-1H-iMidazol-2-yl]benzaMide
• 4-(4-(Benzo[d][1,3]dioxol-5-yl)-5-(pyridin-2-yl)-1H-imid
• TGF-β RI Kinase Inhibitor VI, SB431542 - CAS 301836-41-9 - Calbiochem
• InSolution TGF-β RI Kinase Inhibitor VI, SB431542 - CAS 301836-41-9 - Calbiochem
• CS-89
• 4-[4-(1,3-benzodioxol-5-yl)-5-pyridin-2-yl-1H-imidazol-2-yl]benzamide
• SB 431542, 98%, a potent and selective inhibitor of ALK5
• SB 431542USP/EP/BP
• 4-[4-(1,3-Benzodioxol-5-yl)-5-(2-pyridyl)-1H-imidazol-2-yl]benzamide
• TGF-β RI Kinase Inhibitor VI SB431542 SB-431542
• Transforming growth factor beta receptors,inhibit,TGF-β Receptor,SB-431542,SB431542,Inhibitor
• 301836-41-9
• C22H16N4O3xH2O
• Cell Biology
• Cell Signaling and Neuroscience
• BioChemical
• Cytokines, Growth Factors and Hormones
• Cytokines and Growth Factors
• Inhibitors
• Anti-cancer&immunity
• Smad
• TGF-beta
• Protein Kinase
• Signalling