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Ionomycin

IONOMYCIN Struktur
56092-81-0
CAS-Nr.
56092-81-0
Bezeichnung:
Ionomycin
Englisch Name:
IONOMYCIN
Synonyma:
Ionomycin from Streptomyces conglobatus;EM 94;SQ-23377;IONOMYCIN;SQ 23377, EM 94;Ionomycinefreeacid;IONOMYCIN (SQ23377);IONOMYCIN USP/EP/BP;Ionomycin, Free Base;Ionomycin Free Acid (85%)
CBNumber:
CB5380046
Summenformel:
C41H72O9
Molgewicht:
709.01
MOL-Datei:
56092-81-0.mol
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Ionomycin Eigenschaften

Siedepunkt:
817.2±65.0 °C(Predicted)
Dichte
1.072±0.06 g/cm3(Predicted)
storage temp. 
−20°C
Löslichkeit
Soluble to 10 mM in Ethanol and to 10 mM in DMSO.
Aggregatzustand
Waxy solid
pka
4.77±0.10(Predicted)
Farbe
Yellow
BRN 
3642126
Stabilität:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher Xn,Xi
R-Sätze: 22-36/37/38
S-Sätze: 36-36/37/39-27-26-24/25
WGK Germany  3
RTECS-Nr. NO0650000
F  8-10
HazardClass  3
HS Code  29419090
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H225 Flüssigkeit und Dampf leicht entzündbar. Entzündbare Flüssigkeiten Kategorie 2 Achtung GHS hazard pictogramssrc="/GHS02.jpg" width="20" height="20" /> P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
Sicherheit
P210 Von Hitze, heißen Oberflächen, Funken, offenen Flammen und anderen Zündquellenarten fernhalten. Nicht rauchen.
P240 Behälter und zu befüllende Anlage erden.
P241 Explosionsgeschützte [elektrische/Lüftungs-/ Beleuchtungs-/...] Geräte verwenden.
P303+P361+P353 BEI BERÜHRUNG MIT DER HAUT (oder dem Haar): Alle kontaminierten Kleidungsstücke sofort ausziehen. Haut mit Wasser abwaschen oder duschen.

Ionomycin Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R22:Gesundheitsschädlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-Sätze Betriebsanweisung:

S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S27:Beschmutzte, getränkte Kleidung sofort ausziehen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.

Chemische Eigenschaften

White powder

Verwenden

Ionomycin was isolated from Streptomyces conglobatus as a potent Gram positive antibiotic . During isolation, it was recognised that ionomycin exhibits a very high affinity and selectivity for calcium ions, suggesting the metabolite acts as a calcium ionophore. More recently, ionomycin has been used in cell biology as a universal calcium ionophore to explore the role of calcium regulation in the cell.

Definition

ChEBI: A very long-chain fatty acid that is docosa-10,16-dienoic acid which is substituted by methyl groups at positions 4, 6, 8, 12, 14, 18 and 20, by hydroxy groups at positions 11, 19 and 21, and by a (2',5-dimethyloctahydro-2,2'-bifuran-5-yl)ethanol group at osition 21. An ionophore produced by Streptomyces conglobatus, it is used in research to raise the intracellular level of Ca2+ and as a research tool to understand Ca2+ transport across biological memb anes.

Allgemeine Beschreibung

Highly specific for divalent cations (Ca2+ > Mg2+ >> Sr2+ = Ba2+). More effective than antibiotic A23187 as a mobile ion carrier for Ca2+. Complexes with Ca2+ between pH 7 and 9.5, causing significant absorption in the UV range; however, in contrast to A23187 (Cat. No. 100105), it is not fluorescent. Useful for studies of Ca2+ transport across biological membranes and measurement of cytoplasmic free Ca2+. Induces apoptotic neuronal degeneration in embryonic cortical neurons. Also induces cell cycle arrest in the G1 interval of mature Burkitt lymphoma cell lines.

Biologische Aktivität

Calcium ionophore; more specific than A23187 (5-(Methylamino)-2-[[2R,3R,6S,8S,9R,11R)-3,9,11-trimethyl-8-[(1S)-1-methyl-2-oxo-2-(1H-pyrrol-2-yl)-ethyl]-1,7-dioxaspiro[5.5]undec-2-yl]methyl]-4-benzoxazolecarboxylic acid ).

Ionomycin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Ionomycin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 138)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hubei Ipure Biology Co., Ltd 		+8613367258412
 ada@ipurechemical.com China 10326 58
HONG KONG IPURE BIOLOGY CO.,LIMITED 		86 18062405514 18062405514
 ada@ipurechemical.com CHINA 3465 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250
 1026@dideu.com China 26466 58
BOC Sciences 		16314854226; +16314854226
 inquiry@bocsci.com United States 19743 58
LEAP CHEM CO., LTD. 		+86-852-30606658
market18@leapchem.com China 24738 58
ZHEJIANG JIUZHOU CHEM CO., LTD 		+86-0576225566889 +86-13454675544
 admin@jiuzhou-chem.com；jamie@jiuzhou-chem.com；alice@jiuzhou-chem.com China 19947 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525
 masar@topule.com China 8474 58
LEAPCHEM CO., LTD. 		+86-852-30606658
market18@leapchem.com China 43348 58
Shanghai Acmec Biochemical Technology Co., Ltd. 		+undefined18621343501
 product@acmec-e.com China 33350 58
Aladdin Scientific 		+1-+1(833)-552-7181
sales@aladdinsci.com United States 57511 58

56092-81-0(Ionomycin)Verwandte Suche:

Natrium-1-ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridin-3-carboxylat Actinomycin D Ionomycin
  • (4R,6S,8R,12R,14S,18S,19R,20R,21R)-19,21-Dihydroxy-22-[(2R,5R)-5-[(2R,5S)-5-(1-hydroxyethyl)-5-methyl-oxolan-2-yl]-5-methyl-oxolan-2-yl]-4,6,8,12,14,18,20-heptamethyl-11-oxido-9-oxo-docosa-10,16-dienoate calcium salt
  • SQ-23377
  • Ionomycin,Free Acid,from Streptomyces conglbatus
  • (4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-11,19,21-Trihydroxy-4,6,8,12,14,18,20-heptamethyl-22-[(2S,2'R,5S,5'S)-octahydro-5'-[(1R)-1-hydroxyethyl]-2,5'-dimethyl[2,2'-bifuran]-5-yl]-9-oxo-10,16-docosadienoicacid
  • SQ 23377, EM 94
  • Ionomycin, free acid, from Streptomyces conglobatus
  • (4R,6S,8S,10Z,12R,14R,16E,18S,19S,20R,21S)-11,19,21-Trihydroxy-22-{(2S,2'S,5S,5'R)-5'-[(1S)-1-hydroxyethyl]-2,5'-dimethyloctahydro-2,2'-bifuran-5-yl}-4,6,8,12,14,18,20-heptamethyl-9-oxo-10,16-docosadi enoic acid
  • ionomycin calcium salt from streptomyces conglobatus
  • Ionomycin, Free Acid, Streptomyces conglobatus
  • (4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-11,19,21-Trihydroxy-4,6,8,12,14,18,20-heptamethyl-22-((2S,2'R,5S,5'S)-octahyd
  • Ionomycinefreeacid
  • IONOMYCIN
  • IONOMYCIN, STREPTOMYCES CONGLOBATUS
  • IONOMYCIN (SQ23377)
  • Ionomycin, Free Acid, Streptomyces conglobatus - CAS 56092-81-0 - Calbiochem
  • Ionomycin, Free Acid, Streptomyces conglobatus in Solution - CAS 56092-81-0 - Calbiochem
  • EM 94
  • Ionomycin, 98.5%, from Streptomyces conglobatus
  • 10,16-Docosadienoic acid, 11,19,21-trihydroxy-4,6,8,12,14,18,20-heptamethyl-22-[(2S,2'R,5S,5'S)-octahydro-5'-[(1R)-1-hydroxyethyl]-2,5'-dimethyl[2,2'-bifuran]-5-yl]-9-oxo-, (4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-
  • IONOMYCIN USP/EP/BP
  • Ionomycin Free Acid (85%)
  • Ionomycin from Streptomyces conglobatus
  • (4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-11,19,21-Trihydroxy-22-((2S,2'R,5S,5'S)-5'-((R)-1-hydroxyethyl)-2,5'-dimethyloctahydro-[2,2'-bifuran]-5-yl)-4,6,8,12,14,18,20-heptamethyl-9-oxodocosa-10,16-dienoic acid
  • Ionomycin, Free Base
  • 56092-81-0
  • C41H72O9
  • BioChemical
  • Antibiotics
  • Antibiotics G-M
  • Antibiotics A to Z
  • antibiotic
  • Ion Channels
  • MiscellaneousMore...Close...
  • A - KResearch Essentials
  • Antibacterial
  • Antibiotics A to
  • Antibiotics by Application
  • Antibiotics G-MAntibiotics
  • AntibioticsAntibiotics
  • Calcium channel
  • Spectrum of Activity
  • Chemical Structure Class
  • Core Bioreagents
  • Interferes with Cell Membrane Permeability (Ionophores)Antibiotics
  • Mechanism of Action
  • Antineoplastic and Immunosuppressive AntibioticsAntibiotics
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