Pomalidomide-PEG4-CO2H

Pomalidomide-PEG4-CO2H Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Protein degrader builiding block Pomalidomide-PEG₄-CO₂H enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology.This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant carboxylic acid for reactivity with an amine on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant carboxyl group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition and E3 ligase ligand.

Pomalidomide-PEG4-CO2H Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Pomalidomide-PEG4-CO2H Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58
Xian confluore Biological Technology Co., Ltd.	+86-15680926068 +86-15680926068	1924344760@confluore.cn	China	2996	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57511	58
ChemShuttle, Inc.	0510-83588313-802 18800520310;	sales@chemshuttle.com	China	3000	62
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80
Shanghai Chaolan Chemical Technology Center	QQ:65489617 15618227136	info@SuperLan-chem.com	China	9909	58
Aikon International Limited	025-58851090 13611564524	lwan@aikonchem.com	China	15952	58
Xi'an Confluore Biological Technology Co., Ltd.	+86-156-80926068 +86-15680926068	1924344760@qq.com	China	4824	58
Jilin Province Woda Biotechnology Co., Ltd.	13504435624	1927928688@qq.com	China	1382	58
DC Chemicals	021-58447131 13564518121	sales@dcchemicals.com	China	9412	58

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• POMALIDOMIDE-PEG4-CO 2 H
• Pomalidomide-PEG4-CO2H
• 1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxapentadecan-15-oic acid
• Pomalidomide-PEG4-COOH
• Thalidomide-NH-PEG4-C2-COOH
• Propanoic acid, 3-[2-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]-
• 1-[[2-(2,6-Dioxo-3-piperidyl)-1,3-dioxo-4-isoindolinyl]amino]-3,6,9,12-tetraoxapentadecan-15-oic Acid
• 1-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxapentadecan-15-oic acid, Crosslinker–E3 Ligase ligand conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader
• Poma-PEG4-COOH
• Pomalidomide 4'-PEG4-acid
• 2138440-81-8
• peg