TG003 Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Cdc2-
like kinase (Clk), among a number of other kinases, phosphorylates serine/arginine-
rich proteins which play a role in alternative splicing of pre-
mRNA. The Clk family consists of four members, which include Clk1/Sty and Clk2-
4. TG003 is a novel benzothiazole compound that demonstrates potent inhibition of Clk1/Sty and Clk4 with IC
50 values of 20 and 15 nM, respectively. TG003 exhibits considerably weaker inhibition of Clk2 and Clk3 (IC
50 = 200 nM and >10 μM, respectively). Through suppression of Clk-
mediated phosphorylation, TG003 inhibits SF2/ASF-
dependent splicing of β-
globin pre-
mRNA at 1 μM
in vitro. At 10 μM, TG003 rescues the embryonic defects induced by excessive Clk activity in
Xenopus.
Verwenden
TG003 can be used as a potent CDC-2 kinase inhibitor, allowing for research into identification of signaling pathways and possible therapeutic treatments.
Biochem/physiol Actions
TG003, a CLK (cdc2-like kinase) family inhibitor is used as a drug for duchenne muscular dystrophy.
TG003 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
