AZITHROMYCIN-D3 Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Azithromycin-d
3 is intended for use as an internal standard for the quantification of azithromycin (Item No.
15004) by GC- or LC-MS. Azithromycin is a macrolide antibiotic. It is active against
S. pneumoniae,
S. aureus,
N. gonorrhoeae,
M. pneumoniae,
H. pylori,
C. trachomatis, and
H. influenzae in vitro (MIC
90s = <0.01-2 mg/L). Azithromycin increases survival in mouse models of intraperitoneal
S. pyogenes,
S. pneumoniae,
E. faecalis, or
H. influenzae infection (ED
50s = 0.78, 8.7, 12.7, and 30.3 mg/kg, respectively). It inhibits replication of severe acute respiratory coronavirus 2 (SARS-CoV-2), but not Middle East respiratory syndrome CoV (MERS-CoV), when used at concentrations of 5 and 10 μM. Azithromycin also decreases plasma levels of IL-6, TNF-α, and IL-1β and increases survival in a mouse model of LPS-induced sepsis when administered at a dose of 100 mg/kg. Formulations containing azithromycin have been used in the treatment of a variety of bacterial infections.
Chemische Eigenschaften
White Solid
Verwenden
AzithroMycin-d3 can be used as Semi-synthetic macrolide antibiotic; related to Erythromycin A. Antibacterial.;AzithroMycin-d3 can be intended for use as an internal standard for the quantification of Azithromycin by GC- or LC-mass spectrometry.
AZITHROMYCIN-D3 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
