Acetyl coenzyme A sodium salt Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
R36/38:Reizt die Augen und die Haut.
R39/23/24/25:Giftig: ernste Gefahr irreversiblen Schadens durch Einatmen, Berührung mit der Haut und durch Verschlucken.
R66:Wiederholter Kontakt kann zu spröder oder rissiger Haut führen.
R67:Dämpfe können Schläfrigkeit und Benommenheit verursachen.
S-Sätze Betriebsanweisung:
S24:Berührung mit der Haut vermeiden.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Beschreibung
Acetyl-coenzyme A (acetyl-
CoA), the thioester of CoA and acetic acid, is a pivotal molecule in biological systems. Foremost, it serves as a source of carbon for the Krebs cycle, for the synthesis of fatty acids, and for isoprenoid-
based protein modifications. Acetyl-
CoA also serves as an intermediate in oxidation of fatty acids and amino acids and is formed by the oxidative decarboxylation of pyruvate in mitochondria. It is an essential cofactor or substrate for acetyltransferases and acyltransferases, as in the post-
translational modification of proteins and in the synthesis of the neurotransmitter acetylcholine.
Verwenden
Acetyl-Coenzyme A is used to assay CAT enzyme activity in cell extracts using radioisotopes. CAT enzyme activity in cell extracts catalyzes the transfer of acetyl groups from acetylcoenzyme A to chloramphenicol. A number of assays have been developed to measure CAT activity in cell extracts. Acetyl-Coenzyme A has also been used to determine citrate synthase activity.
Allgemeine Beschreibung
Acetyl-Coenzyme A, trilithium salt
Stoffwechsel
Acetyl coenzyme A, the precursor of the acetate-malonare pathway, is a metabolite of extreme importance in both primary and secondary metabolism. In every living organism, there exists a metabolie pool of acetyl CoA which is continually replenished and depleted. Glycolysis and the catabolism of fatty acids and amino acids produce acetyl CoA, while this compound is the precursor of a host of primary and secondary metabolites, including fatty acids, terpenoids, steroids, polyketides, aromatic compounds and acetyl esters and amides. The conversion of acetyl CoA to citrate and other tricarboxylic acids leads to the formation of the amino acids and their products, such as the nucleic acids and alkaloids.
Acetyl CoA is also central to the catabolism of glucose and the fatty acids, which, through the tricarboxylic acid cycle, are the main reaction sequences producing the energy necessary for metabolie processes.
In plants, an enzyme, acetyl CoA synthetase, catalyses the formation of the thiol ester from acetate.
Acetyl coenzyme A sodium salt Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
