Carmofur
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- CAS-Nr.
- 61422-45-5
- Englisch Name:
- Carmofur
- Synonyma:
- hcfu;HCFUTM;Mifurol;CARMOFUR;Carmofur >Carmofur Carmofur;Carmofur, ≥ 98.0%;Carmofur USP/EP/BP;5-FLUORO-1-HEXYLCARBAMOYLURACIL;1-hexylcarbamoyl-5-fluorouracil
- CBNumber:
- CB5748051
- Summenformel:
- C11H16FN3O3
- Molgewicht:
- 257.26
- MOL-Datei:
- 61422-45-5.mol
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Carmofur Eigenschaften
- Schmelzpunkt:
- 110-111
- Dichte
- 1.2287 (estimate)
- storage temp.
- 2-8°C
- Löslichkeit
- DMSO: >15mg/mL
- Aggregatzustand
- powder
- pka
- 6.94±0.10(Predicted)
- Farbe
- white to off-white
- Merck
- 14,1844
- CAS Datenbank
- 61422-45-5(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Kennzeichnung gefährlicher |
Xi,T |
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| R-Sätze: |
60-61-25 |
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| S-Sätze: |
45 |
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| RIDADR |
UN 2811 6.1 / PGII |
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| WGK Germany |
3 |
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| RTECS-Nr. |
UV7714000 |
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| Hazard Note |
Irritant |
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| HazardClass |
6.1 |
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| PackingGroup |
III |
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| HS Code |
29335990 |
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| Bildanzeige (GHS) |
 
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| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H301 |
Giftig bei Verschlucken. |
Akute Toxizität oral |
Kategorie 3 |
Achtung |
![GHS hazard pictograms]() src="/GHS06.jpg" width="20" height="20" /> |
P264, P270, P301+P310, P321, P330,P405, P501 |
| H361 |
Kann vermutlich die Fruchtbarkeit beeinträchtigen oder das Kind im Mutterleib schädigen. |
Reproduktionstoxizität |
Kategorie 2 |
Warnung |
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P201, P202, P281, P308+P313, P405,P501 |
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| Sicherheit |
| P201 |
Vor Gebrauch besondere Anweisungen einholen. |
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Carmofur Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Carmofur is an inhibitor of acid ceramidase (IC
50 = 79 nM for the rat enzyme) and a derivative of 5-flurouracil . It reduces acid ceramidase activity in a dose- and time-dependent manner and induces intracellular accumulation of various ceramide species, including C18 ceramide , C16 ceramide , and C14 ceramide in SW403 colon and LNCaP prostate cancer cells. Carmofur induces apoptosis in SW403 cells without inhibiting DNA synthesis (IC
50 = 1,212 mM for human thymidylate synthetase). It also reduces acid ceramidase activity and increases ceramide accumulation in mouse lung and brain when administered at doses of 10 and 30 mg/kg.
Verwenden
Carmofur has been used as an inhibitor of acid ceramidase to study its effects on glucosylsphingosine (GlcSph) production in human embryonic kidney 293T (HEK293T) cells. It has also been used as an inhibitor of acid ceramidase to study its effects on acid‐mediated hydrolysis of ceramide which kicks-in consumption and the generation of sphingosine .
Carmofur Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Carmofur Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 192)Lieferanten
61422-45-5()Verwandte Suche:
- 2,4-dioxo-5-fluoro-n-hexyl-1,2,3,4-tetrahydro-1-pyrimidinecarboxamide
- 2,4-dioxo-5-fluoro-n-hexyl-3,4-dihydro-1(2h)-pyrimidinecarboxamidme
- 3,4-dihydro-2,4-dioxo-5-fluoro-n-hexyl-1(2h)-pyrimidinecarboxamid
- hcfu
- 5-FLUORO-1-HEXYLCARBAMOYLURACIL
- CARMOFUR
- HCFUTM
- 1-(N-HEXYLCARBAMOYL)-5-FLUOROURACIL
- 1(2H)-Pyrimidinecarboxamide, 3,4-dihydro-2,4-dioxo-5-fluoro-N-hexyl
- 1-(Hexylcarbamyl)-5-fluorouracil
- 5-Fluoro-N-hexyl-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinecarboxamide
- Mifurol
- HCFUTM, 3,4-Dihydro-2,4-dioxo-5-fluoro-N-hexylpyrimidine-1(2H)-carboxamide
- 5-fluoro-N-hexyl-2,4-dioxo-1,2,3,4-tetrahydropyriMidine-1-carboxaMide
- 5-fluoro-N-hexyl-2,4-dioxo-3,4-dihydropyrimidine-1(2H)-carboxamide
- 1,2,3,4-tetrahydro-2,4-dioxo-5-fluoro-n-hexyl-1-pyrimidinecarboxamid
- 1-hexylcarbamoyl-5-fluorouracil
- Carmofur >
- Carmofur Carmofur
- 1(2H)-Pyrimidinecarboxamide, 5-fluoro-N-hexyl-3,4-dihydro-2,4-dioxo-
- Carmofur USP/EP/BP
- 5-fluoro-N-hexyl-2,4-dioxopyrimidine-1-carboxamide
- Carmofur, ≥ 98.0%
- 61422-45-5
- C11H16FN3O3
- Pharmaceutical material and intermeidates
