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(R)-(4-Oxido-10-oxo-7-palmitoyl-3,5,9-trioxa-4-phosphapentacosyl)trimethylammonium-4-oxid

1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHOCHOLINE Struktur
63-89-8
CAS-Nr.
63-89-8
Bezeichnung:
(R)-(4-Oxido-10-oxo-7-palmitoyl-3,5,9-trioxa-4-phosphapentacosyl)trimethylammonium-4-oxid
Englisch Name:
1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHOCHOLINE
Synonyma:
DPPC;COLFOSCERIL PALMITATE;1,2-DIHEXADECANOYL-SN-GLYCERO-3-PHOSPHOCHOLINE;16:0 PC;DIPALMITOYL LECITHIN;L-A-LECITHIN DIPALMITOYL;DIPALMITOYL-L-ALPHA-LECITHIN;B,G-DIPALMITOYL-L-A-LECITHIN;L-ALPHA-LECITHIN, DIPALMITOYL;1,2-dipalmitoyl-sn-glycero-3-PC
CBNumber:
CB6164209
Summenformel:
C40H80NO8P
Molgewicht:
734.04
MOL-Datei:
63-89-8.mol
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(R)-(4-Oxido-10-oxo-7-palmitoyl-3,5,9-trioxa-4-phosphapentacosyl)trimethylammonium-4-oxid Eigenschaften

Schmelzpunkt:
229-229.5 °C
alpha 
D23 +6.6° (c = 4.2 in 1:1 chloroform-methanol)
storage temp. 
-20°C
Löslichkeit
Chloroform (Slightly), Methanol (Slightly)
Aggregatzustand
Solid
Farbe
White to Off-White
Merck 
14,2477
Stabilität:
Stable. Incompatible with strong oxidizing agents.
InChIKey
KILNVBDSWZSGLL-KXQOOQHDSA-N
CAS Datenbank
63-89-8(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
S-Sätze: 24/25
WGK Germany  3
F  10-21
HS Code  29232000
Bildanzeige (GHS) GHS hazard pictogramsGHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H331 Giftig bei Einatmen. Akute Toxizität inhalativ Kategorie 3 Achtung GHS hazard pictogramssrc="/GHS06.jpg" width="20" height="20" /> P261, P271, P304+P340, P311, P321,P403+P233, P405, P501
H336 Kann Schläfrigkeit und Benommenheit verursachen. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 3 (Schläfrigkeit und Benommenheit) Warnung P261, P271, P304+P340, P312,P403+P233, P405, P501
H351 Kann vermutlich Krebs verursachen. Karzinogenität Kategorie 2 Warnung P201, P202, P281, P308+P313, P405,P501
H372 Schädigt bei Hautkontakt und Verschlucken die Organe bei längerer oder wiederholter Exposition. Spezifische Zielorgan-Toxizität (wiederholte Exposition) Kategorie 1 Achtung GHS hazard pictogramssrc="/GHS08.jpg" width="20" height="20" /> P260, P264, P270, P314, P501
H412 Schädlich für Wasserorganismen, mit langfristiger Wirkung. Langfristig (chronisch) gewässergefährdend Kategorie 3 P273, P501
Sicherheit
P201 Vor Gebrauch besondere Anweisungen einholen.
P273 Freisetzung in die Umwelt vermeiden.
P302+P352 BEI BERÜHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckmäßig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.
P308+P313 BEI Exposition oder falls betroffen: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen.

(R)-(4-Oxido-10-oxo-7-palmitoyl-3,5,9-trioxa-4-phosphapentacosyl)trimethylammonium-4-oxid Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:

S24/25:Berührung mit den Augen und der Haut vermeiden.

Chemische Eigenschaften

white powder

Verwenden

1,2-dipalmitoyl-sn-glycero-3-phosphocholine is a major phospholipid constituent and primary surface tension lowering component of natural lung surfactant. Colfosceril Palmitate is used as pulmonary surfactant and diagnostic aid (fetal lung maturity).

Definition

ChEBI: A phosphatidylcholine 32:0 in which the 1- and 2-acyl groups are specified as hexadecanoyl (palmitoyl). A synthetic phospholipid used in liposomes and lipid bilayers to study biological membranes. It is also a major constituent of pulmonary surfactants.

Allgemeine Beschreibung

Phosphatidylcholine (PC) is a strong bilayer-forming lipid. It the most common phospholipid in mammalian membranes. It is also an important component of the mucosal layer of the colon.

läuterung methode

It has three crystalline forms 1, 2 and ' which change at 60-70o and at 229o, respectively. In order to obtain a fine powder, ~2 g are dissolved in CHCl3 (15mL) and pet ether (b 35-60o) is added; the solution is evaporated to dryness in vacuo at <20o and then dried at 0.1mm over CaCl2. [Baer & Maurukas J Am Chem Soc 74 158 1952, Baer & Kates J Biol Chem 185 615 1950, Beilstein 4 IV 1463.]

(R)-(4-Oxido-10-oxo-7-palmitoyl-3,5,9-trioxa-4-phosphapentacosyl)trimethylammonium-4-oxid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

TYLOXAPOL Hexadecanoic acid, 1,1'-[1-[[(2-oxido-1,3,2-dioxaphospholan-2-yl)oxy]methyl]-1,2-ethanediyl] ester [S,(+)]-1-O,2-O-Dipalmitoyl-3-O-trityl-L-glycerol 2-CHLOROETHYLPHOSPHORIC ACID DICHLORIDE Cholinglycerophosphat (S)-1-(Hydroxymethyl)ethan-1,2-diyldipalmitat Choline tosylate Palmitinsure Trimethylamin, in wässriger Lösung(C > 15%)

Downstream Produkte

1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHOBUTANOL (SODIUM SALT)

(R)-(4-Oxido-10-oxo-7-palmitoyl-3,5,9-trioxa-4-phosphapentacosyl)trimethylammonium-4-oxid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 284)Lieferanten
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63-89-8((R)-(4-Oxido-10-oxo-7-palmitoyl-3,5,9-trioxa-4-phosphapentacosyl)trimethylammonium-4-oxid)Verwandte Suche:

Cholinhydroxid Palmitinsure Trimethyl[2-(phosphonooxy)ethyl]ammoniumchlorid Lecithine (R)-(4-Oxido-10-oxo-7-palmitoyl-3,5,9-trioxa-4-phosphapentacosyl)trimethylammonium-4-oxid (R)-(7-Lauroyl-4-oxido-10-oxo-3,5,9-trioxa-4-phosphaheptacosyl)trimethylammonium-4-oxid
  • 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHOCHOLINE
  • (R)-2,3-Bis(palMitoyloxy)propyl (2-(triMethylaMMonio)ethyl) phosphate
  • LIPOID PE 180/180-PEG
  • 1,2-Dipalmitoyl-sn-glycero-3-phosphocholine,1,2-Dihexadecanoyl-sn-glycero-3-phosphocholine, L-α-Phosphatidylcholine, dipalmitoyl
  • L-alpha-DipalMitoyl phosphatidylcholine, 98% 500MG
  • (7R)-4-Hydroxy-N,N,N-triMethyl-10-oxo- 7-[(1-oxohexadecyl)oxy]-3,5,9-trioxa-4-phosphapentacosan-1-aMiniuM Inner Salt 4-Oxide
  • 1,2-Bis(hexadecanoyl)-sn-glycero-3-phosphocholine
  • 1,2-Bis(pal
  • 1,2-Dihexadecanoyl-sn-glycero-3-phosphocholine 2,3-Bis(palmitoyloxy)propyl [2-(Trimethylammonio)ethyl]phosphate
  • L-b,g-DipalMitoyl-a-lecithin, DPPC
  • DPPC L-1116
  • (7R)-4-Hydroxy-N,N,N-trimethyl-10-oxo-7-[(1-oxohexadecyl)oxy]- 3,5,9-trioxa-4-phosphapentacosan-1-aminium 4-oxide, inner salt
  • 1,2-Dihexadecanoyl-sn-glycero-3-phosphorylcholine
  • 1,2-Dipalmitoyl-L-lecithin
  • L-α-Phosphatidylcholine, dipalmitoyl
  • L-β,γ-Dipalmi
  • (7R)-4-Hydroxy-N,N,N-trimethyl-10-oxo-7-[(1-oxohexadecyl)oxy]- 3,5,9-trioxa-4-phosphapentacosan-1-aminium 4-oxide, inner salt 1,2-Dihexadecanoyl-sn-glycero-3-phosphocholine 1,2-Dihexadecanoyl-sn-glycero-3-phosph
  • 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHO
  • L-alpha-Dipalmitoyl lecithin
  • 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, SEMISYNTHETIC 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, SEMISYNTHETIC 1
  • 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHOCHOLINE 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHOCHOLINE 1,2-DIPALMITOYL-SN-GLYCERO-3-PH
  • L-A-DIPALMITOYL LECITHIN
  • L-a-Lecithin-b,g-dipalmitoyl=DilinoleoylLecithin=Dilinoleoyl-L-a-Lecithin=L-b,g-Dipalmitoyl-a-Lecithin
  • LecithinL-a-Dipalmitoyl
  • L-ALFA-PHOSPHATIDYLCHLOLINE, DIPALMITOYL
  • (R)-(4-oxido-10-oxo-7-palmitoyl-3,5,9-trioxa-4-phosphapentacosyl)trimethylammonium 4-oxide
  • [2-[(R)-2,3-Bis[(1-oxohexadecyl)oxy]propyloxyphosphinatooxy]ethyl]dimethylmethanaminium
  • L-alpha-Dipalmitoyl phosphatidylcholine,98%
  • Colfosceril
  • 3,5,9-Trioxa-4-phosphapentacosan-1-aminium, 4-hydroxy-N,N,N-trimethyl-10-oxo-7-(1-oxohexadecyl)oxy-, inner salt, 4-oxide, (7R)-
  • 3-sn-phosphatidylcholine, 1,2-dipalmitoyl
  • 2-[[(2R)-2,3-dihexadecanoyloxypropoxy]-oxido-phosphoryl]oxyethyl-trimethyl-azanium
  • Dipalmitoyl-L-ALPHA-phosphatidyl choline
  • L-á-Phosphatidylcholine dipalmitoyl
  • Dipalmitoyl-D62-SN-Glycero-3-Phospho-Choline
  • 1,2-Dihexadecanoyl-sn-glycero-3-phosphocholine, L-α-Phosphatidylcholine, dipalmitoyl
  • Coifosceril Palmitate
  • Dipalmitoyl-L-α-glycerylphosphorylcholine
  • ExosurfNeonatal
  • 1,2-dipalmitoyl-sn-glycero-3-phosphocholine(DPPC)
  • CAS_63-89-8
  • Dipalmitoyl sn
  • 1,2-Dipalmitoyl-sn-glycero-3-phosphocholine (Colfosceril Palmitate)
  • 1,2-Dipalmitoyl-sn-glycero-3-phosphocholine>
  • 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHOCHOL
  • 129Y83
  • 16:0 PC (DPPC)
  • L-A-PHOSPHATIDYLCHOLINE, DIPALMITOYL (DPPC) (DIPALMITOYL-D62, 98%)
  • L-DPPC
  • 2,3-Bis(palmitoyloxy)propyl [2-(Trimethylammonio)ethyl] Phosphate
  • 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHOCHOLINE USP/EP/BP
  • 1,2-DIHEXADECANOYL-SN-GLYCERO-3-
  • 1，2-dipalmitoyl-sn-glycero-3-phosphocholine,≥99%
  • 1,2-dipalmitoyl-sn-glycero-3-phosphpcholine
  • 63-89-8 C40H80NO8P 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHOCHOLINE
  • 16:0 PC
  • 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHORYLCHOLINE
  • 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHATIDYLCHOLINE
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