N-Tosyl-5-bromo-4,7-diazaindole

1201186-54-0

CAS-Nr.: 1201186-54-0

Englisch Name:: N-Tosyl-5-bromo-4,7-diazaindole

Synonyma:: 2-BroMo-5-tosyl-5H-pyrrolo[2,3-b]pyrazine;5H-Pyrrolo[2,3-b]pyrazine, 2-bromo-5-[(4-methylphenyl)sulfonyl]-;Upatinib Impurity 2;Upatinib Impurity 45;Upadacitinib Impurity 2;Upadacitinib Impurity 45;N-Tosyl-5-bromo-4,7-diazaindole;Glycerol(Glycerophosphoric acid);3-Bromo-5-tosyl-5H-pyrrolo[2,3-b]pyrazine;2-BROMO-5-(P-TOLYLSULFONYL)-5H-PYRROLO[2,3-B]PYRAZINE

CBNumber:: CB62470216

Summenformel:: C13H10BrN3O2S

Molgewicht:: 352.21

MOL-Datei:: 1201186-54-0.mol

Request For Quotation

Eigenschaften Sicherheit Verwendungswort Produktionsfirma 169

N-Tosyl-5-bromo-4,7-diazaindole Eigenschaften

Siedepunkt:: 499.6±55.0 °C(Predicted)

Dichte: 1.68±0.1 g/cm3(Predicted)

storage temp.: under inert gas (nitrogen or Argon) at 2-8°C

pka: -2.22±0.30(Predicted)

Sicherheit

Risiko- und Sicherheitserklärung
Gefahreninformationscode (GHS)

Bildanzeige (GHS)

Alarmwort

Warnung

Gefahrenhinweise

Code	Gefahrenhinweise	Gefahrenklasse	Abteilung	Alarmwort	Symbol	P-Code
H302	Gesundheitsschädlich bei Verschlucken.	Akute Toxizität oral	Kategorie 4	Warnung	src="/GHS07.jpg" width="20" height="20" />	P264, P270, P301+P312, P330, P501
H315	Verursacht Hautreizungen.	Hautreizung	Kategorie 2	Warnung	src="/GHS07.jpg" width="20" height="20" />	P264, P280, P302+P352, P321,P332+P313, P362
H319	Verursacht schwere Augenreizung.	Schwere Augenreizung	Kategorie 2	Warnung	src="/GHS07.jpg" width="20" height="20" />	P264, P280, P305+P351+P338,P337+P313P
H335	Kann die Atemwege reizen.	Spezifische Zielorgan-Toxizität (einmalige Exposition)	Kategorie 3 (Atemwegsreizung)	Warnung	src="/GHS07.jpg" width="20" height="20" />

Sicherheit

P261	Einatmen von Staub vermeiden.
P305+P351+P338	BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

N-Tosyl-5-bromo-4,7-diazaindole Chemische Eigenschaften,Einsatz,Produktion Methoden

synthetische

A solution of anhydrous DMF (272 mL) dissolved with 2-bromo-5H-pyrrolo[2,3-b]pyrazine (78.0 g, 394 mmol) was configured. The temperature is maintained at 0-5 °C (within which the subsequent reaction has been maintained), and the solution was droppedly added to the sodium (12.8 g, 532 mmol) anhydrous DMF (543 mL) suspension in the stirred state within 60 minutes. The solution turned brown and the reaction solution was stirred for about 30 min. Then, within 60 minutes, anhydrous DMF (272 mL) dissolved with p-toluenesulfonyl chloride (94.0 g, 492 mmol) was added. After stirring the mixed solution for about 1 h, it was heated to ambient temperature and stirred for about 18 h. Slowly pour the reaction mixture into ice water (6 L) and added 2.5 N NaOH in water (50.0 mL, 125 mmol). Filter the sediment to collect and stirred 3 times with cold water (200 mL). Finally, the collected products were filtered and dried to a constant weight in a vacuum oven at about 55 °C to obtain N-Tosyl-5-bromo-4,7-diazaindole (134.6 g, 97%).

Einzelnachweise

[1] Yael Ross, Marina Magrey, Use of upadacitinib in the treatment of psoriatic arthritis, Immunotherapy, 2021, 13.
[2] Lina Serhal, Christopher J Edwards, Upadacitinib for the treatment of rheumatoid arthritis, Expert Review of Clinical Immunology, 2018, 15,13-25.
[3] Eleni Kotsiliti, Upadacitinib therapy for Crohn’s disease, Nature Reviews Gastroenterology & Hepatology, 2023, 20, 483.

N-Tosyl-5-bromo-4,7-diazaindole Upstream-Materialien And Downstream Produkte

Upstream-Materialien

5-Bromo-4,7-diazaindole 5-[(4-methylphenyl)sulfonyl]-5H-Pyrrolo[2,3-b]pyrazin-2-amine 5-bromo-3-((trimethylsilyl)ethynyl)pyrazin-2-amine Tosylchlorid

Downstream Produkte

tert-butyl 5-tosyl-5H-pyrrolo[2,3-b]pyrazin-2-ylcarbamate

N-Tosyl-5-bromo-4,7-diazaindole Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 169)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Golden Pharma Co., Limited	+undefined18958062155	sales@zjgoldpharm.com	China	5905	58
Hangzhou ICH Biofarm Co., Ltd	+86-0571-28186870; +undefined8613073685410	sales@ichemie.com	China	985	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20314	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32760	60
Anhui Dexinjia Biopharm Co., Ltd	+86-531-82375818 +8615064153060	sales01@jndxj.com	China	293	58
Accela ChemBio Inc.	(+1)-858-699-3322	info@accelachem.com	United States	19965	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63711	58
Shanghai Jinghao Pharmaceutical Co.,Ltd	+86-21-68900963	sales@jinghaopharma.com	CHINA	153	58
Shanghai Yingrui Biopharma Co.,Ltd	21-33585366	export01@shyrchem.com	CHINA	1320	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29826	58

N-Tosyl-5-bromo-4,7-diazaindole
2-Bromo-5-[(4-methylphenyl)sulfonyl]-5H-pyrrolo[2,3-b]pyrazine
2-BROMO-5-(P-TOLYLSULFONYL)-5H-PYRROLO[2,3-B]PYRAZINE
2-bromo-5-(4-methylphenyl)sulfonylpyrrolo[2,3-b]pyrazine
2-bromo-5-(4-methylbenzenesulfonyl)-5H-pyrrolo[2,3-b]pyrazine
Upadacitinib Impurity 2
2-BroMo-5-tosyl-5H-pyrrolo[2,3-b]pyrazine
5H-Pyrrolo[2,3-b]pyrazine, 2-bromo-5-[(4-methylphenyl)sulfonyl]-
Glycerol(Glycerophosphoric acid)
3-Bromo-5-tosyl-5H-pyrrolo[2,3-b]pyrazine
Upadacitinib Impurity 45
Upatinib Impurity 2
Upatinib Impurity 45
2-BroMo-5-tosyl-5H-pyrrolo[2,3-b]pyrazine,N-Tosyl-5-bromo-4,7-diazaindole
1201186-54-0
Azaindoles