5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazolehydrobromide
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- CAS-Nr.
- 511296-88-1
- Englisch Name:
- 5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazolehydrobromide
- Synonyma:
- PFT-β;CS-1771;HY-16702A;Pifithrin B;Pifithrin-β;Cyclic PFT-α;Cyclic PFT-α;Pifithrin-beta;Cyclic Pifithrin-α;Pifithrin-β(PPT-β)
- CBNumber:
- CB62518925
- Summenformel:
- C16H16N2S.HBr
- Molgewicht:
- 349
- MOL-Datei:
- 511296-88-1.mol
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5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazolehydrobromide Eigenschaften
- storage temp.
- -20°C
- Löslichkeit
- DMSO: soluble20mg/mL
- Aggregatzustand
- powder to crystal
- Farbe
- White to Almost white
- Merck
- 14,7421
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
WGK Germany |
3 |
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HS Code |
2934.99.4400 |
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Bildanzeige (GHS) |
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Alarmwort |
Warnung |
Gefahrenhinweise |
Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizität (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
src="/GHS07.jpg" width="20" height="20" /> |
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Sicherheit |
P261 |
Einatmen von Staub vermeiden. |
P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen. |
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5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazolehydrobromide Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Pifithrin-
α (PFT-
α; ) is a reversible inhibitor of p53-
dependent transcription and apoptosis. Cyclic PFT-α, also known as PFT-β, is a stable analog of PFT-α, formed by the condensation of pifithrin-α in solution. It inhibits the growth of the cancer cell lines IGROV-1, A2780, and HCT116 (IC
50 = 23, 77, and 103 μM, respectively). At doses lower than those that inhibit growth, cyclic PFT-α induces autophagy in HCT116 cells and sensitizes IGROV-1 and H460 cells to anti-microtubule agents. In addition, 10 μM cyclic PFT-α blocks p53-dependent protection from DNA damage, induced by hydrogen peroxide or ultraviolet radiation, in melanocytes.
Verwenden
Cyclic Pifithrin-α hydrobromide has been used as p53 inhibitor to study its role in cigarette smoke?induced apoptosis of pulmonary endothelial cells.
Biochem/physiol Actions
A stable analog of Pifithrin-α (Product Code P4359) with similar biological activities and lower cellular toxicity.
5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazolehydrobromide Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazolehydrobromide Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 92)Lieferanten
511296-88-1()Verwandte Suche:
- 5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazolehydrobromide
- Cyclic Pifithrin-α hydrobromide
- Pifithrin-beta
- Cyclic Pifithrin-alpha HydrobroMide
- 5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazolehydrobromide Pifithrin-β
- 2-(4-Methylphenyl)imidazo[2,1-b]-5,6,7,8-tetrahydrobenzothiazole hydrobromide
- Cyclic PFT-α hydrobromide
- Pifithrin-α, cyclic
- Cyclic Pifithrin-α HBr
- Pifithrin- beta hydrobromide
- Cyclic PFT-α
- Pifithrin B
- PIFITHRIN-Β;PIFITHRIN B;CYCLIC PFT-Α; PIFITHRIN-Β; PFT-Β
- CS-1771
- CYCLIC PIFITHRIN-Α HYDROBROMIDE;CYCLIC PFT-Α HYDROBROMIDE;PFT-Β HYDROBROMIDE
- HY-16702A
- Cyclic Pifithrin-α Hydrobromide >
- Pifithrin-β
- Cyclic Pifithrin-α
- 2-(p-Tolyl)-5,6,7,8-tetrahydroimidazo[2,1-b]benzothiazole Hydrobromide
- Pifithrin-α, Cyclic, hydrobromide
- Pifithrin-β hydrobromide
- Pifithrin-β HBr (QB102
- Cyclic Pifithrin-α Hydrobromide
- Cyclic PFT-α
- PFT β (hydrobromide)
- PFT-β
- 2-(p-Tolyl)-5,6,7,8-tetrahydrobenzo[d]imidazo[2,1-b]thiazole hydrobromide
- Imidazo[2,1-b]benzothiazole, 5,6,7,8-tetrahydro-2-(4-methylphenyl)-, hydrobromide (1:1)
- 5,6,7,8-tetrahydro-2-(4-methylphenyl)-Imidazo[2,1-b]benzothiazole hydrobromide (1:1)
- inhibit,MDM-2/p53,Pifithrinβ hydrobromide,Ferroptosis,Pifithrin β hydrobromide,Cyclic Pifithrin-α,Inhibitor,PFT β
- Pifithrin-β(PPT-β)
- 511296-88-1
- C16H16N2SHBr
- C16H16N2SBrH