SIRT7 Polyclonal Antibody Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
SIRT7 is a member of a famiy of proteins called sirtuins (SIR2-
like proteins) and are present in prokaryotes and eukaryotes. All SIR2-
like proteins have a sirtuin core domain, which contains a series of sequence motifs conserved in organisms ranging from bacteria to humans. Bacterial, yeast, and mammalian sirtuins are able to metabolize NAD
+ and several act as mono-
ADP-
ribosyltransferases. The enzymatic function of sirtuins is not yet completely understood but recent reports of histone-
activated SIR2-
mediated NAD
+ metabolism and NAD
+-
activated SIR2-
mediated histone deacetylation suggest a possible coupled reciprocal activation mechanism involving interactions of SIR2 with NAD
+ and the N-
ε-
acetyl-
lysine groups of acetylated histone.
SIRT7 Polyclonal Antibody Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
