ANTI-AMYLOID, BETA- (1-40), HUMAN

ANTI-AMYLOID, BETA- (1-40), HUMAN Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Anti-β-Amyloid Protein (1-40) antibody produced in rabbit has been used in:

• immunocytochemical localization of Aβ peptides
• immunocytochemistry
• immunoprecipitation
• focused ultrasound-microbubble enhanced antibody delivery (FUS-MB)

Allgemeine Beschreibung

Amyloid precursor proteins (APPs) are members of a large family of 70 kDa transmembrane glycoproteins that are found in a wide range of tissues. APP is expressed in the brain. It is located on human chromosome 21. APPs have three main isoforms, namely, APP₆₉₅, APP₇₅₁ and APP₇₇₀, that are derived from alternative splicing events in cells.

Biochem/physiol Actions

The β-amyloid precursor protein (APP) is cleaved sequentially by the proteolytic enzymes β-secretase (BACE1) and γ-secretase to produce β-amyloid (Aβ) peptides with the Aβ1-42 and the Aβ1-40 forms being the most prevalent. Secreted Aβ peptides are degraded either via a re-uptake mechanism followed by endosomal degradation, or by an extracellular insulin degrading enzyme. Extracellular accumulation of Aβ leads to the formation of aggregates, fibrils and eventually amyloid deposits called neuritic plaques, which is the hallmark of Alzheimer′s disease (AD).Rabbit Anti-β-Amyloid Protein (1-40) antibody does not stain control sections of normal brain tissues.

ANTI-AMYLOID, BETA- (1-40), HUMAN Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

ANTI-AMYLOID, BETA- (1-40), HUMAN Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Riedel-de Haen AG	--		United States	6825	87
SIGMA-RBI	--		Switzerland	6913	91
Alexis Corporation	--	alexis-ch@alexis-corp.ch	Switzerland	3599	74
Kanto Chemical Co., Inc.	--	reag-info@gms.kanto.co.jp	Japan	6762	74
Peptide Institute, Inc.	--	info@peptide.co.jp	Japan	992	70
Chemicon Internatinal, Inc.	--	custserv@chemicon.com	United States	4175	65
EMD Biosciences, Inc.	--	technical@calbiochem.com	United States	6529	66
VWR International	--	solutions@vwr.com	United Kingdom	6554	82
BIOTREND Chemikalien GmbH	--	jaeger@biotrend.com	Germany	6115	76
Zymed Laboratories Inc.	--		United States	3068	86

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• Anti-β-Amyloid Protein (1-40) antibody produced in rabbit
• BETA-AMYLOID (1-40) (AB-1) POLYCLONAL ANTIBODY
• ANTI-HUMAN AMYLOID BETA [1-40]
• ANTI-AMYLOID BETA-PROTEIN (1-40)
• ANTI-AMYLOID BETA-PROTEIN (1-40)-CLONE OM16
• ANTI AMYLOID BETA PROTEIN (1-40) (HUMAN)
• ANTI-AMYLOID BETA-PROTEIN (HUMAN, 1-40)
• ANTI-AMYLOID, BETA 1-40
• ANTI-AMYLOID, BETA- (1-40), HUMAN
• ANTI-BETA-AMYLOID [1-40] (AB-1)
• ANTI-BETA-AMYLOID (1-40), HUMAN
• ANTI-BETA-AMYLOID (1-40) RABBIT PAB
• ANTI-BETA-AMYLOID PEPTIDE
• ANTI-BETA-AMYLOID PEPTIDE (1-40) (HUMAN)
• RABBIT ANTI-HUMAN AMYLOID BETA [1-40]
• AM-AZAntibodies for Neurobiology
• Antibodies for Alzheimer and Neurodegenerative Disease Research
• Antibodies for Neurodegenerative Diseases Research
• Alphabetical Index
• Antibodies