2-[[[2-(4-ethylphenyl)-5-methyl-4-oxazolyl]methyl]thio]-N-(2-phenylethyl)acetamide

901751-47-1

CAS-Nr.: 901751-47-1

Englisch Name:: 2-[[[2-(4-ethylphenyl)-5-methyl-4-oxazolyl]methyl]thio]-N-(2-phenylethyl)acetamide

Synonyma:: iCRT3;CS-2716;ICRT3;ICRT-3;ICRT 3;Inhibitor,Wnt,Apoptosis,inhibit,iCRT-3,iCRT3,iCRT 3;2-[[[2-(4-ethylphenyl)-5-methyl-4-oxazolyl]methyl]thio]-N-(2-phenylethyl)acetamide;Acetamide, 2-[[[2-(4-ethylphenyl)-5-methyl-4-oxazolyl]methyl]thio]-N-(2-phenylethyl)-

CBNumber:: CB62750484

Summenformel:: C23H26N2O2S

Molgewicht:: 394.53

MOL-Datei:: 901751-47-1.mol

Request For Quotation

Eigenschaften Sicherheit Verwendungswort Produktionsfirma 45

2-[[[2-(4-ethylphenyl)-5-methyl-4-oxazolyl]methyl]thio]-N-(2-phenylethyl)acetamide Eigenschaften

Dichte: 1.150±0.06 g/cm3(Predicted)

storage temp.: 2-8°C

Löslichkeit: DMSO: ≥5mg/mL

Aggregatzustand: powder

pka: 14.62±0.46(Predicted)

Farbe: white to tan

Sicherheit

Risiko- und Sicherheitserklärung
Gefahreninformationscode (GHS)

Kennzeichnung gefährlicher	Xn
R-Sätze:	22-37/38-41
S-Sätze:	26-39
WGK Germany	3

Bildanzeige (GHS)

Alarmwort

Achtung

Gefahrenhinweise

Code	Gefahrenhinweise	Gefahrenklasse	Abteilung	Alarmwort	Symbol	P-Code
H302	Gesundheitsschädlich bei Verschlucken.	Akute Toxizität oral	Kategorie 4	Warnung	src="/GHS07.jpg" width="20" height="20" />	P264, P270, P301+P312, P330, P501
H315	Verursacht Hautreizungen.	Hautreizung	Kategorie 2	Warnung	src="/GHS07.jpg" width="20" height="20" />	P264, P280, P302+P352, P321,P332+P313, P362
H318	Verursacht schwere Augenschäden.	Schwere Augenschädigung	Kategorie 1	Achtung	src="/GHS05.jpg" width="20" height="20" />	P280, P305+P351+P338, P310
H335	Kann die Atemwege reizen.	Spezifische Zielorgan-Toxizität (einmalige Exposition)	Kategorie 3 (Atemwegsreizung)	Warnung	src="/GHS07.jpg" width="20" height="20" />

Sicherheit

P261	Einatmen von Staub vermeiden.
P280	Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P305+P351+P338	BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

2-[[[2-(4-ethylphenyl)-5-methyl-4-oxazolyl]methyl]thio]-N-(2-phenylethyl)acetamide Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

iCRT3, is an inhibitor of both Wnt and β-catenin-responsive transcription (CRT).

Allgemeine Beschreibung

iCRT3 is a small cell-permeable oxazole compound. It blocks cytokine secretion in lipopolysaccharide (LPS)-stimulated macrophages.

Biochem/physiol Actions

The key mediator of Wnt signaling is the transcriptional co-activator b-catenin. In the cytoplasm, b-catenin is tightly bound to a complex that includes Axin and GSK-3b. Stimulation causes b-catenin stabilization, translocation to the nucleus and association with TCF4 to initiate transcription of responsive genes, referred to as Catenin Responsive Transcription (CRT). Virtually all Wnt-associated cancers are the result of misregulated CRT. Three inhibitors of CRT (iCRT) were identified in a screen that employed RNAi based knockdown of Axin, which stimulates CRT without affecting upstream mechanisms such as GSK activity, transduction by disheveled / frizzled, etc. These compounds are potent inhibitors of CRT reporter genes, as well as endogenous gene targets. The compounds also disrupt b-catenin-TCF4 interaction in a dose dependent manner, and cause G0/G1 arrest in colon tumor lines.

2-[[[2-(4-ethylphenyl)-5-methyl-4-oxazolyl]methyl]thio]-N-(2-phenylethyl)acetamide Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

2-[[[2-(4-ethylphenyl)-5-methyl-4-oxazolyl]methyl]thio]-N-(2-phenylethyl)acetamide Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 45)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32760	60
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8474	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20314	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57511	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131980	58
Shanghai Yu Ben Biotechnology Co., Ltd.	15502154572	yuben012@sina.com	China	507	58
ShangHai Caerulum Pharma Discovery Co., Ltd.	18149758185	sales-cpd@caerulumpharma.com	China	3460	58
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80

2-[[[2-(4-ethylphenyl)-5-methyl-4-oxazolyl]methyl]thio]-N-(2-phenylethyl)acetamide
CS-2716
ICRT3;ICRT-3;ICRT 3
Acetamide, 2-[[[2-(4-ethylphenyl)-5-methyl-4-oxazolyl]methyl]thio]-N-(2-phenylethyl)-
iCRT3
Inhibitor,Wnt,Apoptosis,inhibit,iCRT-3,iCRT3,iCRT 3
901751-47-1