OLPRINONE HYDROCHLORIDE
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- CAS-Nr.
- 119615-63-3
- Englisch Name:
- OLPRINONE HYDROCHLORIDE
- Synonyma:
- e1020;Coretec;OLPRINONE HCL;xo-,monohydrochloride,monohydrate;Olprinone hydrochloride - Loprinone hydrochloride;3-pyridinecarbonitrile,1,2-dihydro-5-(imidazo(1,2-a)pyridin-6-yl)-6-methyl-2-o;1,2-Dihydro-5-imidazo[1,2-α]pyridin-6-yl-6-methyl-2-oxo-3-pyridinecarbonitrile Hydrochloride;3-Pyridinecarbonitrile,1,2-dihydro-5-imidazo[1,2-a]pyridin-6-yl-6-methyl-2-oxo-,monohydrochloride;Loprinone hydrochloride, 1,2-Dihydro-5-(imidazo[1,2-a]pyridin-6-yl)-6-methyl-2-oxo-3-pyridinecarbonitrile hydrochloride
- CBNumber:
- CB6504070
- Summenformel:
- C14H11ClN4O
- Molgewicht:
- 286.72
- MOL-Datei:
- 119615-63-3.mol
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OLPRINONE HYDROCHLORIDE Eigenschaften
- Schmelzpunkt:
- >3000C
- storage temp.
- 2-8°C
- Löslichkeit
- DMSO: ≤4 mg/mL
- Aggregatzustand
- solid
- Farbe
- beige
OLPRINONE HYDROCHLORIDE Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Coatec was launched in Japan for acute cardiac insufficiency in cases
resistant to other treatments. There are three related synthetic routes, 5-6 steps
each, to loprinone all converging on 1-(imidazo[1,2a]pyridyl-6-yl)-Zpropanone as an
advanced intermediate. It is a potent and selective inhibitor of PDE Ⅲ and a long
lasting, orally active, positive inotropic agent. The PDE Ⅲ inhibition caused
increased levels of CAMP which leads to the positive inotropic effect that was not
altered by β or H
2-preceptor antagonists. It was 100 times less potent at PDE I and
PDE Ⅱ with no Na-K-ATPase activity. Improved hemodynamic parameters with slight
changes in heart rate and blood pressure were seen in vivo. It is not mutagenic and
its primary metabolite was less active.
Chemische Eigenschaften
Off-White Crystalline Powder
OLPRINONE HYDROCHLORIDE Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
OLPRINONE HYDROCHLORIDE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 58)Lieferanten
119615-63-3()Verwandte Suche:
- 3-pyridinecarbonitrile,1,2-dihydro-5-(imidazo(1,2-a)pyridin-6-yl)-6-methyl-2-o
- e1020
- xo-,monohydrochloride,monohydrate
- OLPRINONE HCL
- 1,2-Dihydro-5-imidazo[1,2-α]pyridin-6-yl-6-methyl-2-oxo-3-pyridinecarbonitrile Hydrochloride
- Coretec
- Loprinone hydrochloride, 1,2-Dihydro-5-(imidazo[1,2-a]pyridin-6-yl)-6-methyl-2-oxo-3-pyridinecarbonitrile hydrochloride
- 3-Pyridinecarbonitrile,1,2-dihydro-5-imidazo[1,2-a]pyridin-6-yl-6-methyl-2-oxo-,monohydrochloride
- Olprinone hydrochloride - Loprinone hydrochloride
- 119615-63-3
- C14H10N4OHCl
- Heterocyclic Compounds
- Heterocycles
- Intermediates & Fine Chemicals
- Pharmaceuticals
