Vardenafil hydrochloride

Vardenafil hydrochloride Struktur
224785-91-5
CAS-Nr.
224785-91-5
Englisch Name:
Vardenafil hydrochloride
Synonyma:
VARDENAFIL HCL;Vardenafi;Nuviva;fafinafei;Valdenafil;Levitra, Valdenafil;vardenafil USP/EP/BP;Levitra,Valdenafil.HCl;Vardenafil 224785-91-5;Vardenafil / Vardenafil
CBNumber:
CB6672278
Summenformel:
C23H33ClN6O4S
Molgewicht:
525.07
MOL-Datei:
224785-91-5.mol

Vardenafil hydrochloride Eigenschaften

Schmelzpunkt:
214-216°C
storage temp. 
Store at -20°C
Löslichkeit
DMSO: 100 mg/mL (190.45 mM); Water: ≥ 100 mg/mL (190.45 mM)
Aggregatzustand
Solid
Farbe
White to Off-White Cyrstalline
InChIKey
XCMULUAPJXCOHI-UHFFFAOYSA-N
SMILES
C(C1=NC(C)=C2C(N=C(C3C=C(S(N4CCN(CC)CC4)(=O)=O)C=CC=3OCC)NN12)=O)CC.Cl
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
HS Code  2933299090
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H301 Giftig bei Verschlucken. Akute Toxizität oral Kategorie 3 Achtung GHS hazard pictogramssrc="/GHS06.jpg" width="20" height="20" /> P264, P270, P301+P310, P321, P330,P405, P501
H311 Giftig bei Hautkontakt. Akute Toxizität dermal Kategorie 3 Achtung GHS hazard pictogramssrc="/GHS06.jpg" width="20" height="20" /> P280, P302+P352, P312, P322, P361,P363, P405, P501
H331 Giftig bei Einatmen. Akute Toxizität inhalativ Kategorie 3 Achtung GHS hazard pictogramssrc="/GHS06.jpg" width="20" height="20" /> P261, P271, P304+P340, P311, P321,P403+P233, P405, P501
Sicherheit
P261 Einatmen von Staub vermeiden.
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P271 Nur im Freien oder in gut belüfteten Räumen verwenden.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P302+P352 BEI BERÜHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckmäßig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.
P304+P340 BEI EINATMEN: Die Person an die frische Luft bringen und für ungehinderte Atmung sorgen.
P310 Sofort GIFTINFORMATIONSZENTRUM/Arzt/ anrufen.
P330 Mund ausspülen.
P361 Alle kontaminierten Kleidungsstücke sofort ausziehen.
P403+P233 An einem gut belüfteten Ort aufbewahren. Behälter dicht verschlossen halten.
P405 Unter Verschluss aufbewahren.
P501 Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

Vardenafil hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Vardenafil was the second agent to be marketed and had the advantage that its onset time was not reduced by taking the medication on a full stomach . It is 30 times more potent as an inhibitor of PDE5 (mean IC50, 3.9 nM) than sildenafil and 10 times more potent than tadalafil, with a greater selectivity (>1,000 times) for human PDE5 than for human PDE2, PDE3, and PDE4 and moderate selectivity (>80 times) for PDE1. The PDE inhibitory selectivity and both the in vitro and in vivo potency of the new PDE5 inhibitor vardenafil. Vardenafil specifically inhibited the hydrolysis of cGMP by PDE5, with an IC50 of 0.7 nM (sildenafil 6.6 nM). The IC50 of vardenafil for PDE1 was 180 nM, for PDE6 11 nM, and for PDE2, PDE3 and PDE4 more than 1,000 nM.

Chemische Eigenschaften

White to Off-White Cyrstalline Solid

Verwenden

vardenafil hydrochloride is a selective phsphodiesterase type 5 (pde5) inhibitor that is used as a urological agent in the treatment of erectile dysfunction.

Allgemeine Beschreibung

Vardenafil, 4-[2-ethoxy-5-(4-ethylpiperazin-1-yl)sulfonyl-phenyl]-9-methyl-7-propyl-3,5,6,8-tetrazabicyclo[4.3.0]nona-3,7,9-trien-2-one(Levitra), was the second PDE5 introduced in the U.S. market.The metabolism of vardenafil is primarily by CYP3A4.As such, concomitant use of CYP3A4 inhibitors such as ritonavir,indinavir, ketoconazole, as well as moderate CYP3Ainhibitors such as erythromycin typically results in significantincreases of plasma levels of vardenafil.

in vitro

Vardenafil hydrochloride specifically inhibits the hydrolysis of cGMP by PDE5 with an IC50 of 0.7 nM. Vardenafil hydrochloride increases intracellular cGMP levels in the cavernosum tissue of the penis, thus results increasing the dilation of the body's sinuses and blood flow.

Enzyminhibitor

Vardenafil also is rapidly absorbed and peaks in concentration (9.05 μg/mL after a 10-mg dose) after 0.9 hours, displaying a half-life of 4 to 5 hours. The absorption rate of both sildenafil and vardenafil are reduced when taken with a high-fat diet. The drug also is metabolized by hepatic CYP3A4, and a potential for drug–drug interaction with inhibitors or enhancers of CYP3A4 exists. Biochemical studies demonstrate a significant increase in selectivity of vardenafil over sildenafil for PDE5 versus PDE6. Whether this translates into a significant improvement in side effects must await studies in a greater population of patients.

Vardenafil hydrochloride Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Vardenafil hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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224785-91-5()Verwandte Suche:


  • 1-[[3-(1,4-dihydro-5-methyl-4-oxo-7-propylimidazo[5,1-f][1,2,4]triazin-2-yl)-4-ethoxyphenyl]sulfonyl]-4-ethyl-piperazine dihydrochloride
  • 2-[2-Ethoxy-5-(4-ethylpiperazin-1-yl)sulfonylphenyl]-5-methyl-7-propyl-1H-imidazo[5,1-f][1,2,4]triazin-4-one hydrochloride
  • vardenafil hydrochloride
  • Vardenafil Hydrochloride Trihydrate 224785-90-4 /
  • Levitra,Valdenafil.HCl
  • 1-[[3-(1,4-Dihydro-5-methyl-4-oxo-7-propylimidazo[5,1-f][1,2,4]triazin-2-yl)-4-ethoxyphenyl]sulfonyl]-4-ethyl-piperazine
  • Nuviva
  • VARDENAFILMONOHYDROCHLORIDE(SUBJECTTOPATENTFREE)
  • VARDENAFIL, HYDROCHLORIDE SALT
  • Vardenafil, Hydrochloride Salt Discontinued See V098001
  • Levitra, Valdenafil
  • Valdenafil
  • Vardenafil 224785-91-5
  • Buy vardenafil CAS 224785-91-5 from China vardenafil supplier factory CAS NO.224785-91-5
  • Hot sell sex powder API CAS 224785-91-5 vardenafil powder CAS NO.224785-91-5
  • vardenafil CAS 224785-91-5
  • fafinafei
  • Vardenafil HCl Vardenafil kf-wang(at)kf-chem.com
  • 2-[2-Ethoxy-5-[(4-ethyl-1-piperazinyl)sulphonyl]phenyl]-5-methyl-7-propyl-1H-imidazo[5,1-f][1,2,4]triazin-4-one hydrochloride 97%
  • 2-[2-Ethoxy-5-[(4-ethyl-1-piperazinyl)sulphonyl]phenyl]-5-methyl-7-propyl-1H-imidazo[5,1-f][1,2,4]triazin-4-one hydrochloride
  • Vardenafil hydrochloride CAS 224785-91-5
  • 2-{2-ethoxy-5-[(4-ethylpiperazin-1-yl)sulfonyl]phenyl}-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(1H)-one dihydrochloride
  • vardenafil USP/EP/BP
  • China Factroy Supply 99% Pure Vardenafil Powder
  • 2-{2-ethoxy-5-[(4-ethylpiperazin-1-yl)sulfonyl]phen yl}-5-methyl-7-propyl-1H,4H-imidazo[4,3-f][1,2,4]tri azin-4-one hydrochloride
  • VARDENAFIL HCL
  • Vardenafi
  • Vardenafil / Fardenafil / Levitra
  • 2-(2-Ethoxy-5-((4-ethylpiperazin-1-yl)sulfonyl)phenyl)-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(1H)-one hydrochloride
  • Vardenafil / Vardenafil
  • Vardenafil HCl in Methanol
  • 224785-91-5
  • 24785-91-5
  • C23H34Cl2N6O4S
  • C23H33ClN6O4S
  • C23H32N6O4SHCl
  • C23H32N6O4SClH3H2O
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Vardenafil
  • API
  • 224785-91-5
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