Otiloniumbromid

Otilonium bromide Struktur
26095-59-0
CAS-Nr.
26095-59-0
Bezeichnung:
Otiloniumbromid
Englisch Name:
Otilonium bromide
Synonyma:
Otilonium;OCTYLONIUM BROMIDE;Spasmomen;SPASMONEN;SP-63;Spasen;Doralin;Menoctyl;Pasminox;Spasmome
CBNumber:
CB6712880
Summenformel:
C29H43BrN2O4
Molgewicht:
563.58
MOL-Datei:
26095-59-0.mol

Otiloniumbromid Eigenschaften

Schmelzpunkt:
130-133°C
storage temp. 
-20°C
Löslichkeit
DMSO (Slightly), Methanol (Slightly)
Aggregatzustand
powder
Farbe
white to beige
CAS Datenbank
26095-59-0(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Toxizität LD50 in mice (mg/kg) 87.0 i.p.
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

Otiloniumbromid Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Otilonium is an inhibitor of L-type (IC50 = 2.3 μM) and T-type calcium channels (IC50s = 0.8, 1.1, and 0.4 μM for Cav3.1, Cav3.2, and Cav3.3, respectively). It is also an antagonist of muscarinic acetylcholine receptors (mAChRs; IC50s = 0.054, 0.4, 0.222, and 0.156 μM for M1, M2, M4, and M5 muscarinic receptors, respectively) and the platelet activating factor (PAF) receptor (IC50 = 0.0552 μM). Otilonium inhibits the inward calcium current in isolated rat colonic smooth muscle cells (EC50 = 885 nM), an effect that can be blocked by the L-type calcium channel inhibitor nifedipine . It inhibits contractions induced by the muscarinic acetylcholine receptor (mAChR) agonist methacholine in isolated circular muscle of the guinea pig proximal colon (IC50 = 3.7 μM). Otilonium (4 mg/kg) decreases fecal excretion and wet dog shakes and increases the tail withdrawal latency in the tail-flick test in a rat model of opioid withdrawal syndrome induced by morphine and naloxone.

Chemische Eigenschaften

White Powder

Verwenden

Otilonium bromide is an antimuscarinic

Allgemeine Beschreibung

Otilonium bromide is an antispasmodic. It contains a red color ACh (acetylcholine) like moiety bound to an aromatic system that ends with an octyl ether.

Sicherheitsprofil

Poison by intraperitoneal route. Moderately toxic by ingestion and subcutaneous routes. When heated to decomposition it emits toxic fumes of Brí and NOx.

Otiloniumbromid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Otiloniumbromid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 214)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Mojin Biotechnology Co., Ltd
+86 13288715578 +8613288715578
sales@hbmojin.com China 12835 58
Hebei Yanxi Chemical Co., Ltd.
+8617531190177
peter@yan-xi.com China 5857 58
Wuhan Fortuna Chemical Co., Ltd
+86-027-59207850
info@fortunachem.com China 5975 58
Capot Chemical Co.,Ltd.
+86-(0)57185586718 +86-13336195806
sales@capot.com China 29791 60
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21634 55
Hangzhou FandaChem Co.,Ltd.
+8615858145714
FandaChem@Gmail.com China 9087 55
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29880 58
Shenzhen Nexconn Pharmatechs Ltd
+86-755-89396905 +86-15013857715
admin@nexconn.com China 10311 58
Hubei xin bonus chemical co. LTD
86-13657291602
linda@hubeijusheng.com CHINA 22963 58
Beijing Yibai Biotechnology Co., Ltd
0086-182-6772-3597
sales04@yibaibiotech.com CHINA 419 58

26095-59-0(Otiloniumbromid)Verwandte Suche:


  • Menoctyl
  • N,N-Diethyl-N-methy-2-[[4-[[2-(octyloxy)benzoyl]amino]benzoyl]oxy]ethanaminium Bromide
  • Pasminox
  • SP-63
  • Spasen
  • Spasmoctyl
  • Spasmome
  • OTYLONIUMBROMIDE
  • diethyl-methyl-[2-[4-[(2-octoxybenzoyl)amino]benzoyl]oxyethyl]azanium bromide
  • Aotixiuan
  • OtioniuM BroMide
  • OtiloniuM broMide(OctyloniuM broMide)
  • Octylonium IodideDiscontinued See: O293250
  • Ethanaminium, N,N-diethyl-N-methyl-2-[[4-[[2-(octyloxy)benzoyl]amino]benzoyl]oxy]-, bromide (1:1)
  • ammonium,diethyl(2-hydroxyethyl)methyl-,bromide,p-(o-(octyloxy)benzamido)ben
  • diethyl(2-hydroxyethyl)methylammoniumbromidep-(o-(octyloxy)benzamido)benzoa
  • ethanaminium,n,n-diethyl-n-methyl-2-((4-((2-(octyloxy)benzoyl)amino)benzoyl)
  • octylonium
  • ottiloniobromuro
  • n,n-diethyl-n-methyl-2-((4-((2-(octyloxy)benzoyl)amino)benzoyl)oxy)-ethanaminium bromide
  • OCTYLONIUM IODIDE
  • otilonium bromide
  • diethyl(2-hydroxyethyl) methylammonium bromide p-(o-(octyloxy)benzamido)-benzoate
  • Doralin
  • diethyl-[2-[[4-[[(2-heptoxyphenyl)-oxomethyl]amino]phenyl]-oxomethoxy]ethyl]-methylammonium bromide
  • aoixijan
  • DORALIN;OCTYLONIUM BROMIDE;SP63;SPASMOMEN
  • Otilonium bromide USP/EP/BP
  • Otilonium bromideQ: What is Otilonium bromide Q: What is the CAS Number of Otilonium bromide Q: What is the storage condition of Otilonium bromide
  • Otilonium
  • Spasmomen
  • OCTYLONIUM BROMIDE
  • SPASMONEN
  • Isoleucine Impurity 14
  • 26095-59-0
  • C29H43BrN2O4
  • C29H43IN2O4
  • C29H43N2O4Br
  • BrC29H43N2O4
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
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