Necrostatin-1
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- CAS-Nr.
- 4311-88-0
- Englisch Name:
- Necrostatin-1
- Synonyma:
- Nec 1;CS-959;NECROSTATIN-1;MTH-DL-TRYPTOPHAN;IFLAB-BB F0911-6127;Necrostatin-1, >=98%;Necrostatin-1 (Nec-1);Necrostatin-1 USP/EP/BP;Ceftobiprole Impurity 24;NECROSTATIN1; NECROSTATIN 1
- CBNumber:
- CB6776886
- Summenformel:
- C13H13N3OS
- Molgewicht:
- 259.33
- MOL-Datei:
- 4311-88-0.mol
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Necrostatin-1 Eigenschaften
- Schmelzpunkt:
- 151℃
- Siedepunkt:
- 441.9±37.0 °C(Predicted)
- Dichte
- 1.40±0.1 g/cm3 (20 ºC 760 Torr)
- Flammpunkt:
- 93.3℃
- storage temp.
- -20°C
- Löslichkeit
- DMSO: >10 mg/mL
- Aggregatzustand
- solid
- pka
- 9.46±0.40(Predicted)
- Farbe
- Pale yellow
- Sensitive
- Light Sensitive
- Stabilität:
- Stable for 2 years from date of purchase as supplied.? Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H317 |
Kann allergische Hautreaktionen verursachen. |
Sensibilisierung der Haut |
Kategorie 1A |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P261, P272, P280, P302+P352,P333+P313, P321, P363, P501 |
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| Sicherheit |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
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Necrostatin-1 Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Necrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-α-induced necroptosis with EC50 of 490 nM.
Biologische Aktivität
ATP-competitive death domain receptor-associated adaptor kinase (RIP1) allosteric inhibitor (EC 50 = 182 nM). Blocks non-apoptotic cell death via inhibition of a specific cellular pathway, necroptosis, which leads to necrosis (EC 50 = 494 nM). Reduces ischemic brain injury in a mouse model of stroke.
Biochem/physiol Actions
Necrostatin-1(Nec-1) might exhibit therapeutic benefit against patients with traumatic brain injury (TBI). In addition, it might also be used to treat other acute central nervous system (CNS) disorders that feature necroptosis as a mode of cell death. It is extensively used to study the effect of receptor-interacting protein kinase 1 (RIPK1) on cell death and inflammation in experimental disease models. Nec‐1 protects hippocampal (HT‐22) cells from glutamate‐induced oxytosis via increasing cellular glutathione (GSH) levels, decreasing reactive oxygen species production, inhibiting the nuclear translocation of apoptosis‐inducing factor and B-cell lymphoma 2 (Bcl‐2) /adenovirus E1B 19kDa‐interacting protein 3‐related pathways.
Necrostatin-1 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Necrostatin-1 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 172)Lieferanten
4311-88-0()Verwandte Suche:
- Necrostatin-1, >=98%
- IFLAB-BB F0911-6127
- 5-(INDOL-3-YLMETHYL)-3-METHYL-2-THIO-HYDANTOIN
- NECROSTATIN-1
- MTH-DL-TRYPTOPHAN
- MTH-DL-Tryptophan Methylthiohydantoin-DL-tryptophan
- 5-(1H-INDOL-3-YLMETHYL)-3-METHYL-2-THIOXO-4-IMIDAZOLIDINONE
- 5-(1H-Indole-3ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone
- 5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-Imidazolidinone, 5-(Indol-3-ylmethyl)-3-methyl-2-thio-hydantoin, MTH-DL-Tryptophan
- Nec 1
- Methylthiohydantoin-DL-tryptophan, MTH-DL-tryptophan
- 4-IMidazolidinone, 5-(1H-indol-3-ylMethyl)-3-Methyl-2-thioxo-
- 5-((1H-indol-3-yl)Methyl)-3-Methyl-2-thioxoiMidazolidin-4-one
- 5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone Necrostatin 1
- Necrostatin 1 5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone
- CS-959
- NECROSTATIN1; NECROSTATIN 1
- Necrostatin-1 - CAS 4311-88-0 - Calbiochem
- Methylthiohydantoin-DL-tryptophan
- NECROSTATIN1;NECROSTATIN 1;METHYLTHIOHYDANTOIN-DL-TRYPTOPHAN
- Necrostatin-1 USP/EP/BP
- Necrostatin-1 (Nec-1)
- 5-(1H-indol-3-ylmethyl)-3-methyl-2-sulfanylideneimidazolidin-4-one
- Receptor-interacting protein kinases,Inhibitor,RIP kinase,RIPK,Nec 1,Ferroptosis,Necrostatin1,Nec1,Necrostatin-1,inhibit,Autophagy,Indoleamine 2,3-Dioxygenase (IDO)
- Ceftobiprole Impurity 24
- 4311-88-0
- Cell Biology
- Cell Signaling and Neuroscience
- Apoptosis and Cell Cycle
- Apoptosis Inhibitors
- BioChemical
- Inhibitors
- Apoptosis Inhibitors
- Miscellaneous Signaling
- Inhibitor
