Trimetrexate glucuronate
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- CAS-Nr.
- 82952-64-5
- Englisch Name:
- Trimetrexate glucuronate
- Synonyma:
- CI 898 dihydrochloride;CI 898 TRIHYDROCHLORIDE;Trimetrexate glucuronate;CI 898 D-Glucuronic Acid Salt (Trimetrexate D-Glucuronic Acid Salt);5-Methyl-6-[[(3,4,5-trimethoxyphenyl)amino]methyl]quinazoline-2,4-diamine D-glucuronate;5-Methyl-6-[[(3,4,5-trimethoxyphenyl)amino]methyl]-2,4-quinazolinediaminetrihydrochloride
- CBNumber:
- CB6850867
- Summenformel:
- C25H33N5O10
- Molgewicht:
- 563.56
- MOL-Datei:
- 82952-64-5.mol
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Trimetrexate glucuronate Eigenschaften
- storage temp.
- Store at -20°C
- Aggregatzustand
- Solid
- Farbe
- Off-white to light yellow
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H361 |
Kann vermutlich die Fruchtbarkeit beeinträchtigen oder das Kind im Mutterleib schädigen. |
Reproduktionstoxizität |
Kategorie 2 |
Warnung |
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P201, P202, P281, P308+P313, P405,P501 |
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| Sicherheit |
| P201 |
Vor Gebrauch besondere Anweisungen einholen. |
| P202 |
Vor Gebrauch alle Sicherheitshinweise lesen und verstehen. |
| P281 |
Vorgeschriebene persönliche Schutzausrüstung verwenden. |
| P308+P313 |
BEI Exposition oder falls betroffen: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen. |
| P405 |
Unter Verschluss aufbewahren. |
| P501 |
Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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Trimetrexate glucuronate Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Trimetrexate glucuronate is a nonclassical antifolate introduced in the
U.S.A. and Canada as second-line therapy for the treatment of Pneumocystis carinii
pneumonia (PCP) and toxoplasmosis in AIDS patients who are refractory or
intolerant to co-trimoxazole therapy. Trimetrexate glucuronate is reportedly to be in
clinical trials for the treatment of several types of cancer including colorectal,
gastric, pancreas, prostate, bladder, lung, breast, head, and neck cancers. It is
also in early clinical trials for topical use in treating psoriasis and as an oral drug to
treat rheumatoid arthritis. The mechanism of action of trimetrexate glucuronate is
via inhibition of the enzyme dihydrofolate reductase which mediates the reduction of
dihydrofolate to tetrahydrofolic acid and results in disruption of DNA, RNA and
protein synthesis, with consequent cell death. Due to its toxicity to bone marrow
and the GI tract, trimetrexate glucuronate must be concurrently administered with
leucovorin as a rescue agent.
Verwenden
Antineoplastic.
Biologische Aktivität
Potent lipophilic inhibitor of dihydrofolate reductase (DHFR) that displays antineoplastic and antiprotozoal properties. Inhibits protozoal, bacterial and human DHFR with IC 50 values of 1.4, 6.1 and 3.2 nM respectively. Affects G 1 /S phase cell cycle progression.
Trimetrexate glucuronate Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Trimetrexate glucuronate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 12)Lieferanten
82952-64-5()Verwandte Suche:
- Trimetrexate glucuronate
- 5-Methyl-6-[[(3,4,5-trimethoxyphenyl)amino]methyl]-2,4-quinazolinediaminetrihydrochloride
- CI 898 dihydrochloride
- CI 898 TRIHYDROCHLORIDE
- 5-Methyl-6-[[(3,4,5-trimethoxyphenyl)amino]methyl]quinazoline-2,4-diamine D-glucuronate
- CI 898 D-Glucuronic Acid Salt (Trimetrexate D-Glucuronic Acid Salt)
- 82952-64-5
- C19H23N5O33HCl
- C19H23N5O3C6H10O7
- C25H33N5O10
