1,5-Dihydropyrimido[5,4-d]pyrimidin-2,4,6,8(3H,7H)tetron

2,4,6,8-Tetrahydroxy-Pyrimido-(5,4D)Pyrimidine Struktur
6713-54-8
CAS-Nr.
6713-54-8
Bezeichnung:
1,5-Dihydropyrimido[5,4-d]pyrimidin-2,4,6,8(3H,7H)tetron
Englisch Name:
2,4,6,8-Tetrahydroxy-Pyrimido-(5,4D)Pyrimidine
Synonyma:
Nsc20089;Homouric;tetratomic;homouric acid;Dipyridamole Impurity 8;2,6,8,10-Tetrahydroxy-homopurine;Pyrimido[5,4-d]Pyrimidine Impurity 1;Pyrimido[5,4-d]pyrimidine-2,4,6,8-tetrol;pyrimido[5,4-d]pyrimidine-2,4,6,8-tetraol;pyriMido[5,4-d][1,3]diazine-2,4,6,8-tetrol
CBNumber:
CB6875585
Summenformel:
C6H4N4O4
Molgewicht:
196.12
MOL-Datei:
6713-54-8.mol

1,5-Dihydropyrimido[5,4-d]pyrimidin-2,4,6,8(3H,7H)tetron Eigenschaften

Dichte
1.89±0.1 g/cm3(Predicted)
pka
5.90±0.20(Predicted)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H332 Gesundheitsschädlich bei Einatmen. Akute Toxizität inhalativ Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P261, P271, P304+P340, P312
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

1,5-Dihydropyrimido[5,4-d]pyrimidin-2,4,6,8(3H,7H)tetron Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

2,4,6,8-Tetrahydroxy-Pyrimido(5,4-d)Pyrimidine is a pharmaceutical intermediate used in the preparation of Dipyridamole, an antiplatelet drug that is used primarily in the treatment of ischaemic heart disease and stroke. 2,4,6,8-Tetrahydroxy-Pyrimido(5,4-d)Pyrimidine is also used as a herbicide to control broadleaf weeds in wheat crops.

Synthese

2,4,6,8-Tetrahydroxy-Pyrimido-(5,4d)Pyrimidine is prepared by the reaction of 5-amino-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid and urea. The specific synthesis steps are as follows:
5-amino-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid was charged into a two nicked flask, Urea (7.7 g, 128.0 mmol) was added dropwise with 125 ml of NaOH solution (500 g of sodium hydroxide + 1500 g of purified water) After dripping rapidly warming to 100 ° C,Insulation for one hour; continue to stir 3h,(25 ° C), filtered to obtain a solid, add purified water 250ml, heated to 60 ° C, heat lh, and then add dilute hydrochloric acid to ΡΗ = 4, cooled to room temperature filtration, washed and dried to obtain pyrimidine [5 , 4-d] pyrimidine-2,4,6,8-tetraol (tetrahydroxy), and recrystallized (ethanol solvent) to give 10.9 g in 86.9% yield.
2,4,6,8-Tetrahydroxy-Pyrimido-(5,4D)Pyrimidine synthesis

1,5-Dihydropyrimido[5,4-d]pyrimidin-2,4,6,8(3H,7H)tetron Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


1,5-Dihydropyrimido[5,4-d]pyrimidin-2,4,6,8(3H,7H)tetron Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 125)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Capot Chemical Co.,Ltd.
571-85586718 +8613336195806
sales@capotchem.com China 29798 60
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21663 55
Zhejiang ZETian Fine Chemicals Co. LTD
+8618957127338
stella@zetchem.com China 2136 58
Standardpharm Co. Ltd.
86-714-3992388
overseasales1@yongstandards.com United States 14335 58
Alchem Pharmtech,Inc.
8485655694
sales@alchempharmtech.com United States 63711 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 49403 58
career henan chemical co
+86-0371-86658258 +8613203830695
factory@coreychem.com China 29821 58
Neostar United (Changzhou) Industrial Co., Ltd.
+86-0519-85551759 +8613506123987
marketing1@neostarunited.com China 8836 58
Zhengzhou Alfa Chemical Co.,Ltd
+8618530059196
sale04@alfachem.cn China 13402 58
SIMAGCHEM CORP
+86-13806087780
sale@simagchem.com China 17367 58

6713-54-8(1,5-Dihydropyrimido[5,4-d]pyrimidin-2,4,6,8(3H,7H)tetron)Verwandte Suche:


  • 1,5-dihydropyrimido[5,4-d]pyrimidine-2,4,6,8(3H,7H)tetrone
  • 2,6,8,10-Tetrahydroxy-homopurine
  • 2,4,6,8-Tetrahydroxy-Pyrimido-(5,4D)Pyrimidine
  • Homouric
  • homouric acid
  • 1,2,3,4,5,6,7,8-Octahydropyrimido[5,4-d]pyrimidine-2,4,6,8-tetrone
  • Pyrimido[5,4-d]pyrimidine-2,4,6,8(1H,3H,5H,7H)-tetrone
  • Pyrimido[5,4-d]pyrimidine-2,4,6,8-tetrol
  • Nsc20089
  • pyriMido[5,4-d][1,3]diazine-2,4,6,8-tetrol
  • pyriMido[5,4-d]pyriMidine-2,4,6,8(1H,3H,5H,7H)-tetraone
  • pyrimido[5,4-d]pyrimidine-2,4,6,8-tetraol
  • 1H,2H,3H,4H,5H,6H,7H,8H-[1,3]DIAZINO[5,4-D]PYRIMIDINE-2,4,6,8-TETRONE
  • 1,5-dihydropyrimido[5,4-d]pyrimidine-2,4,6,8-tetrone
  • ,4,6,8-Tetrahydroxy-Pyrimido-(5,4D)Pyrimidine
  • Dipyridamole Impurity 8
  • Pyrimido[5,4-d]Pyrimidine Impurity 1
  • 2,4,6,8-TETRAHYDROXYPYRIMIDO-[5,4-D]PYRIMIDIN
  • Pyrimido[5,4-d]pyrimidine-2,4,6,8(3H,7H)-tetrone, 1,5-dihydro-
  • 2,4,6,8-Tetrahydroxy-pynmido[5,4-d]pynmidine
  • tetratomic
  • 6713-54-8 2,4,6,8-Tetrahydroxy-Pyrimido-(5,4D)Pyrimidine
  • 2,4,6, 8-tetrahydroxy pyrimidine and [5, 4-D] pyrimidine
  • 6713-54-8
  • Heterocycle-Pyrimidine series
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