Paromomycin

paromomycin Struktur
7542-37-2
CAS-Nr.
7542-37-2
Bezeichnung:
Paromomycin
Englisch Name:
paromomycin
Synonyma:
Aminosidine;R 400;Humycin;Catenulin;Aminosidin;Gabromycin;Paucimycin;Crestomycin;Amminosidin;Gabbromycin
CBNumber:
CB6911922
Summenformel:
C23H45N5O14
Molgewicht:
615.63
MOL-Datei:
7542-37-2.mol

Paromomycin Eigenschaften

alpha 
D25 +65 ±3°
Siedepunkt:
658.93°C (rough estimate)
Dichte
1.3753 (rough estimate)
Brechungsindex
1.7500 (estimate)
Löslichkeit
Methanol (Slightly), Water (Slightly)
Aggregatzustand
Solid
pka
12.93±0.70(Predicted)
Farbe
Off-White to Pale Beige
Stabilität:
Hygroscopic

Sicherheit

Toxizität LD50 in rats, mice (mg/kg): >1625, >2275 orally; >650, 423 s.c.; 156, 90 i.v. (Coffey)

Paromomycin Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Paromomycin is recommended for treatment of acute and chronic forms of intestinal amobiasis, as well as for treating intestinal bacteria Salmonella and Shigella. Synonyms of this drug are aminosidine, catenulin, crestomycin, hydroxymycin, monomycin, zygomycyn, and others.

Indications

The antibacterial activity and indications for using paromomycin are analogous to those of neomycin. In addition, it is recommended for treating severe and chronic forms of gastric amebiasis. Synonyms of this drug are aminosidine, catenulin, crestomycin, hydroxymycin, monomycin, zygomycyn, and others.

Weltgesundheitsorganisation (WHO)

Paromomycin, an aminoglycoside antibiotic was introduced into medicine in 1959 for the treatment of protozoal, helminthic and bacterial infections. It has been associated, particularly when used by parenteral route, with severe adverse effects including renal damage, neuromuscular blockage and ototoxicity, possibly leading to deafness in some patients. This route of administration is now considered obsolete. However, parenteral dosage forms of paromomycin may still remain available in certain countries.

Antimicrobial activity

A fermentation product of Streptomyces rimosus var. paromomycinus, supplied as the sulfate. The commercial product is a mixture of the two isomeric paromomycins I and II, which are closely related to neomycin.
The antibacterial activity is almost identical to that of neomycin. Since it differs from neomycin in having a hydroxyl rather than an amino group at the 6′-position it is not sensitive to AAC(6′) modifying enzymes. It is active against M. tuberculosis, including multidrug-resistant strains, and the M. avium complex.
Unlike other aminoglycosides, paromomycin is active against some protozoa, including Entamoeba histolytica, Cryptosporidium parvum, Leishmania spp., Giardia lamblia and Trichomonas vaginalis. It also exhibits activity against the tapeworms Taenia saginata, Taenia solium, Diphyllobothrium latum and Hymenolepis nana.
It closely resembles neomycin in pharmacokinetic behavior and liability to produce deafness and intestinal malabsorption.

Clinical Use

Intestinal amebiasis (oral)
Cutaneous leishmaniasis (topical) and visceral leishmaniasis (intramuscular)
Nitroimidazole-resistant trichomoniasis (topical)
Its antiprotozoal activity has attracted some attention, but it has largely been superseded by more active and less toxic compounds. Success in treating nitroimidazole-resistant trichomoniasis with topical paromomycin has been reported. Trials in India and East Africa of parenteral paromomycin alone, or in combination with sodium stibogluconate, for treatment of visceral leishmaniasis have shown promising results.

Paromomycin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Paromomycin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 25)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
BOC Sciences
+1-631-485-4226
inquiry@bocsci.com United States 19553 58
career henan chemical co
+86-0371-86658258 15093356674;
factory@coreychem.com China 29826 58
AFINE CHEMICALS LIMITED
+86-0571-85134551
info@afinechem.com China 15395 58
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571-88938639 +8617705817739
info@dycnchem.com China 52861 58
PT CHEM GROUP LIMITED
+86-85511178 +86-85511178
peter68@ptchemgroup.com China 35451 58
GIHI CHEMICALS CO.,LIMITED
+8618058761490
info@gihichemicals.com China 49999 58
China National Standard Pharmaceutical Corporation Limited
+8615391658522
overseasales@yongstandards.com China 11927 58
GIHI CHEMICALS CO.,LIMITED 08657186217390
sales@gihichemicals.com CHINA 309 58
Gihi Chemicals Co., Limited +86-0571-86217390 +8618058761490
info@gihichem.com China 998 58
Beijing HuaMeiHuLiBiological Chemical 010-56205725
waley188@sohu.com China 12338 58

7542-37-2(Paromomycin)Verwandte Suche:


  • PAROMOMYCIN,O-2-AMINO-2-DEOXY-ALPHA-D-GLUCOPYRANOSYL-(1-4)-O-[O-2,6-DIAMINO-2,6-DIDEOXY--L-IODOPYRANOSYL-(1-3)--D-RIBOFURANOSYL-(1-5)]-2-DEOXY-D-STREPTAMINE
  • Paromomycinsulfat
  • Aminosidin
  • Aminosidine I
  • Amminosidin
  • Antibiotic 2230D
  • Antibiotic 503-3
  • Antibiotic SF 767B
  • Crestomycin
  • D-Streptamine, O-2-amino-2-deoxy-a-D-glucopyranosyl-(14)-O-[O-2,6-diamino-2,6-dideoxy-b-L-idopyranosyl-(13)-b-D-ribofuranosyl-(15)]-2-deoxy- (9CI)
  • Gabbromicina
  • Gabbromycin
  • Gabromycin
  • Humycin
  • Hydroxymycin (6CI)
  • Monomycin A
  • Paromomycin I
  • Paromomycine
  • Paucimycin
  • Quintomycin C
  • R 400
  • Streptamine, O-2,6-diamino-2,6-dideoxy-b-L-idopyranosyl-(13)-O-b-D-ribofuranosyl-(15)-O-[2-amino-2-deoxy-a-D-glucopyranosyl-(14)]-2-deoxy- (8CI)
  • Zygomycin A1 (7CI)
  • 4-O-(2-Amino-2-deoxy-α-D-glucopyranosyl)-5-O-[3-O-(2,6-diamino-2,6-dideoxy-β-L-idopyranosyl)-β-D-ribofuranosyl]-2-deoxy-D-streptamine
  • Hydroxymycin
  • Catenulin
  • paromomycin
  • D-Streptamine, O-2,6-diamino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-O-β-D-ribofuranosyl-(1→5)-O-[2-amino-2-deoxy-α-D-glucopyranosyl-(1→4)]-2-deoxy-
  • Framycetin Impurity 5 (Framycetin EP Impurity E)
  • Aminosidine
  • Framycetin Sulfate Impurity 5 (Framycetin Sulfate EP Impurity E)
  • 7542-37-2
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