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Sitagliptin phosphate

Sitagliptin phosphate Struktur
654671-78-0
CAS-Nr.
654671-78-0
Englisch Name:
Sitagliptin phosphate
Synonyma:
Sitagliptin Phosphat;3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]-pyrazin-7(8H)-yl)-4-(2,4,5-t;(3R)-3-aMino-1-[3-(trifluoroMethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;SIT-11;CS-1358;sitagpliptin;Sitagliptin, MK 0431;Sitagliptin phosphate;Sitagliptin Phosphatec;Sitagliptin phosphate salt
CBNumber:
CB71179744
Summenformel:
C16H15F6N5O.H3PO4
Molgewicht:
505.31
MOL-Datei:
654671-78-0.mol
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Sitagliptin phosphate Eigenschaften

Schmelzpunkt:
202-204°C
storage temp. 
-20°C Freezer
Löslichkeit
Methanol (Slightly, Heated), Water (Sparingly, Sonicated)
Aggregatzustand
Solid
Farbe
White to Off-White
InChI
InChI=1S/C16H15F6N5O.H3O4P/c17-10-6-12(19)11(18)4-8(10)3-9(23)5-14(28)26-1-2-27-13(7-26)24-25-15(27)16(20,21)22;1-5(2,3)4/h4,6,9H,1-3,5,7,23H2;(H3,1,2,3,4)
InChIKey
IQFYVLUXQXSJJN-UHFFFAOYSA-N
SMILES
C(C1=CC(F)=C(F)C=C1F)C(N)CC(=O)N1CCN2C(C(F)(F)F)=NN=C2C1.P(O)(O)(O)=O
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

Sitagliptin phosphate Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Sitagliptin is the first novel dipeptidyl peptidase IV inhibitor from Merck for the treatment of type 2 diabetes without weight gain and the incidence of hypoglycemia was similar to placebo. Sitagliptin acts by enhancing the body’s incretin system, which helps to regulate glucose by affecting β and α cells in the pancreas.

Chemische Eigenschaften

White Solid

Verwenden

A trizolopyrazine dipeptidyl peptidase IV inhibitor. It has recently been approved for the therapy of type II diabetes.

Allgemeine Beschreibung

Sitagliptin phosphate is the 1:1 phosphoric acid salt ofsitagliptin free base (i.e., (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)-2-butanamine), and is marketed(Junuvia, 2006) in 25-, 50-, and 100-mg tablets. Acombination product with metformin (Janumet, 2007) intwo strengths (50 mg/500 mg and 50 mg/1,000 mgsitagliptin/metformin) is also available, and sitagliptin mayalso be prescribed with a thiazolidinedione, or possibly a sulfonylurea.The phosphate salt provides very high water solubility.The bioavailability of orally administered sitagliptinis～87%. The drug exhibits relatively low plasma protein binding (～38%), a relatively large volume of distribution(198 L), and a terminal elimination half-life of 12 hours.About 79% of a 100-mg oral dose is excreted unchanged inurine, the balance as trace-level metabolites (CYP3A4, lessercontribution by CYP2C8) in urine or feces: 87% of administeredradioactivity is excreted in urine, and 13% in feces.Active tubular excretion is reported to play a key role in renalclearance of unchanged drug, and may be mediated at least inpart via the organic anion transporter hOAT-3.

Sitagliptin phosphate Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Sitagliptin phosphate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 373)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Shanghai Jinhuan Chemical CO.,LTD.
+86-21-52210535 +8613162045318
 sales@jinhchem.com China 331 58
Protheragen-ING
+16313385890
 info@protheragen-ing.com United States 3868 58
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 sales1@chuanghaibio.com China 5892 58
Hangzhou Hyper Chemicals Limited 		+86-0086-57187702781 +8613675893055
 info@hyper-chem.com China 295 58
Shaanxi TNJONE Pharmaceutical Co., Ltd 		+8618092446649
 sarah@tnjone.com China 1143 58
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. 		+86-18600796368 +86-18600796368
 sales@sjar-tech.com China 444 58
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497
sales01@cooperate-pharm.com CHINA 1803 55
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512
 info@tianfuchem.com China 21634 55
Shanghai Time Chemicals CO., Ltd. 		+86-021-57951555 +8617317452075
 jack.li@time-chemicals.com China 1803 55
Hangzhou FandaChem Co.,Ltd. 		+8615858145714
 FandaChem@Gmail.com China 9206 55

654671-78-0()Verwandte Suche:

[4-(4-Amino-6,7-dimethoxy-quinazolin-2- yl)piperazin-1-yl]-(2,5-dioxabi cyclo[4.4.0]deca-6,8,10-trien-4-yl)methanone Oseltamivir phosphate Prazosin Trinatriumorthophosphat Doxazosin mesylate PHOSPHATE BUFFER Alfuzosin 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)4-[(tetrahydro-2-furanyl)carbonyl]piperazine hydrochloride 2,3,5,6-Tetramethyl-pyrazin Terazosin 2,6-Dimethyloct-7-en-2-ol Tricalciumbis(orthophosphat) Sitagliptin Tributylphosphat Pregna-1,4-dien-3,20-dion, 9-Fluor-11,17-dihydroxy-16-methyl-21-(phosphonooxy)-, Dinatriumsalz, (11β,16β)- Hexadecyldihydrogenphosphat Tylosin, Phosphat (Salz) phosphate
  • 7-[(3R)-3-Amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-α]pyrazine-phosphate
  • Sitagliptin phosphate
  • 4-Oxo-4-(3-(trifluoromethyl)-5,6-dihydro(1,2,4)triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-amine phosphate
  • sitagpliptin
  • Sitagliptin phosphate 4-Oxo-4-(3-(trifluoromethyl)-5,6-dihydro(1,2,4)triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-amine phosphate
  • Sitagliptin phosphate/Sitagliptin phosphate Monohydrate/Sitagliptin
  • Sitagliptin phosphate (Cas:654671-78-0...
  • (3R)-3-Amino-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-1-butanone phosphate
  • 1-Butanone, 3-amino-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-, (3R)-, phosphate (1:1)
  • Sitagliptin, MK 0431
  • CS-1358
  • Sitagliptin phosphate salt
  • 99% Sitagliptin Phosphate?
  • Sitagliptin phosphate USP/EP/BP
  • Sitagliptin phosphate (API)
  • Sitagliptin PhosphateQ: What is Sitagliptin Phosphate Q: What is the CAS Number of Sitagliptin Phosphate Q: What is the storage condition of Sitagliptin Phosphate
  • Sitagliptin Phosphatec
  • 3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]-pyrazin-7(8H)-yl)-4-(2,4,5-t
  • (3R)-3-aMino-1-[3-(trifluoroMethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
  • Sitagliptin Phosphat
  • SIT-11
  • Sitagliptin Phosphate (Monohydrate and Anhydrous)
  • Sitagliptin Impurity 14 Phosphate
  • Siagliptin phosphate monohydrate
  • Sitagliptin Impurity 19 Phosphate
  • 654671-78-0
  • C16H15F6N5OH3O4P
  • C16H15F6N5OH3PO4
  • API
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  • 654671-78-0
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