ANANDAMIDE
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- CAS-Nr.
- 94421-68-8
- Englisch Name:
- ANANDAMIDE
- Synonyma:
- AEA;ARACHIDONOYL ETHANOLAMIDE;N-ARACHIDONOYLETHANOLAMINE;ARACHIDONYLETHANOLAMIDE;(5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-tetraenamide;8Z;ANANDAMIDE;14-tetraenamide;ANANDAMIDE AEA?;anandamide(20.4,n-6)
- CBNumber:
- CB7168648
- Summenformel:
- C22H37NO2
- Molgewicht:
- 347.53
- MOL-Datei:
- 94421-68-8.mol
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ANANDAMIDE Eigenschaften
- Siedepunkt:
- 522.3±50.0 °C(Predicted)
- Dichte
- 0.92 g/mL at 25 °C (lit.)
- Flammpunkt:
- 14 °C
- storage temp.
- -20°C
- Löslichkeit
- ethanol: soluble
- Aggregatzustand
- oil
- pka
- 14.48±0.10(Predicted)
- Farbe
- light yellow
- Wasserlöslichkeit
- 413ug/L(25 ºC)
- Stabilität:
- Stable for 1 year from date of purchase as supplied. Subject to oxidation – protect from air. Solutions in degassed DMSO or ethanol may be stored under nitrogen or argon at -80°C for up to 1 month.
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Kennzeichnung gefährlicher |
F |
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| R-Sätze: |
11 |
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| S-Sätze: |
24/25-16-7 |
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| RIDADR |
UN 1170 3/PG 2 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
JX3842500 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H314 |
Verursacht schwere Verätzungen der Haut und schwere Augenschäden. |
Ätzwirkung auf die Haut |
Kategorie 1B |
Achtung |
![GHS hazard pictograms]() src="/GHS05.jpg" width="20" height="20" /> |
P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501 |
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| Sicherheit |
| P271 |
Nur im Freien oder in gut belüfteten Räumen verwenden. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P301+P330+P331 |
BEI VERSCHLUCKEN: Mund ausspülen. KEIN Erbrechen herbeiführen. |
| P304+P340 |
BEI EINATMEN: Die Person an die frische Luft bringen und für ungehinderte Atmung sorgen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen. |
| P310 |
Sofort GIFTINFORMATIONSZENTRUM/Arzt/ anrufen. |
| P363 |
Kontaminierte Kleidung vor erneutem Tragen waschen. |
| P403+P233 |
An einem gut belüfteten Ort aufbewahren. Behälter dicht verschlossen halten. |
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ANANDAMIDE Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R11:Leichtentzündlich.
S-Sätze Betriebsanweisung:
S24/25:Berührung mit den Augen und der Haut vermeiden.
S16:Von Zündquellen fernhalten - Nicht rauchen.
S7:Behälter dicht geschlossen halten.
Definition
ChEBI: An N-(polyunsaturated fatty acyl)ethanolamine resulting from the formal condensation of carboxy group of arachidonic acid with amino group of ethanolamine.
Hazard
A reproductive hazard.
Biologische Aktivität
Endogenous cannabinoid and vanilloid receptor agonist, in water-soluble emulsion (for details see TocrisolveTM 100). K i values are 89 and 371 nM for CB 1 and CB 2 receptors respectively; EC 50 values are 18, 31 and 27 nM at GPR55, CB 1 and CB 2 respectively; pK i = 5.68 for rVR1. Also blocks TNF- α -induced NF-kB activation via direct inhibition of IKK. Also available as the pure oil dissolved in ethanol (N-(2-Hydroxyethyl)-5Z,8Z,11Z,14Z-eicosatetraenamide ).
Enzyminhibitor
This lipid neurotransmitter and endocannabinoid receptor ligand (FW = 347.54 g/mol; CAS 94421-68-8), also known as arachidonylethanolamide, inhibits calcium ion currents and activates the MAP kinase signaling pathway. Anandamide is a naturally occurring effector of central and peripheral nervous systems, as mediated by CB1 and CB2 cannabinoid receptors, respectively. (These receptors were originally characterized as binding Δ9 -tetrahydrocannabinol, or THC, marijuana’s major psychoactive ingredient.) Anandamide, 2-arachidonoylglycerol, and congeners (N- oleoylethanolamide and N-palmitoylethanolamide) are lipophilic signalling molecules with multiple physiological roles in learning and memory, neuroinflammation, oxidative stress, neuroprotection and neurogenesis. Anandamide likewise plays a role in regulating uterine implantation of the early-stage embryo (blastocyst). Anandamide synthesis occurs from N- acetylphosphatidylethanolamine by multiple pathways that include phospholipase A2, phospholipase C, and NAPE-hydrolyzing phospholipase D (or NAPE-PLD). Target(s): adenylate cyclase; Na + channels; a7-nicotinic acetylcholine receptor; 5 HT3 receptors; Ca 2+ channels; K+ channels, voltage-gated; acylglycerol lipase, or monoacylglycerol lipase.
ANANDAMIDE Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
ANANDAMIDE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 83)Lieferanten
94421-68-8()Verwandte Suche:
- Arachidonylethanolamide,AEA, Anandamide, Arachidonic acid N-(hydroxyethyl)amide
- Anandamide (in Tocrisolve 100)
- Arachidonoyl Ethanolamide Lipid Maps MS Standard
- (5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)-5,8,11,14-eicosatetraenamide
- ARACHIDONYLETHANOLAMIDE, >=97.0% (TL
- 11,14-eicosatetraenamide(all-z)-n-(2-hydroxyethyl)-8
- 14-eicosatetraenamide,n-(2-hydroxyethyl)-(all-z)-11
- 5,8,11,14-eicosatetraenoylethanolamide
- anandamide(20.4,n-6)
- n-(2-hydroxyethyl)anachidonamide
- n-arachidonoyl-2-hydroxyethylamide
- ARACHIDONIC ACID N-[HYDROXYETHYL]AMIDE
- 5,8,11,14(Z,Z,Z,Z)-EICOSATETRAENOYL 2'-HYDROXYETHYL-AMIDE
- ANANDAMIDE
- N-(2-HYDROXYETHYL)-5Z,8Z,11Z,14Z-EICOSATETRAENAMIDE
- Anandamide(inTocrisolveTM100)
- AEA, Anandamide, Arachidonic acid N-(hydroxyethyl)amide
- 5,8,11,14-Eicosatetraenamide, N-(2-hydroxyethyl)-, (5Z,8Z,11Z,14Z)-
- 5,8,11,14-Eicosatetraenamide, N-(2-hydroxyethyl)-, (all-Z)-
- N-(2-Hydroxyethyl)-5,8,11,14-eicosatetraenamide (all-Z)-
- Arachidonoyl Ethanolamide (in ethanol)
- Arachidonoyl Ethanolamide MaxSpecStandard
- ANANDAMIDE/AEA Powder
- Anandamide CAS 94421 68 8
- (5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-tetraenami...
- 14-tetraenamide
- 14Z)-N-(2-Hydroxyethyl)icosa-5
- 8Z
- ARACHIDONOYL ETHANOLAMIDE
- ARACHIDONYLETHANOLAMIDE
- AEA
- N-ARACHIDONOYLETHANOLAMINE
- (5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-tetraenamide
- Transient receptor potential channels,Inhibitor,inhibit,Alzheimer’s disease,Candida albicans,Anandamide,anti-fungal,anti-adhesive,cervical epithelial cells,Endogenous Metabolite,G protein-coupled receptor 55,Streptozotocin,hVSMC,HeLa cells,GPR55,TRP Channel,Cannabinoid Receptor,endocannabinoid,Peroxisome proliferator-activated receptors,Fungal,PPAR,Tau Protein
- ANANDAMIDE AEA?
- 94421-68-8
- C22H37NO2
- Unsaturated fatty acids and derivatives
- Polyunsaturated
- Lipids
- Fatty Acids
- Fatty acid amides
- BioChemical
- Biochemicals and Reagents
- Cannabinoid receptor
- Cannabinoid
