(S)-4-Methyloxazolidin-2,5-dion

(S)-4-Methyl-2,5-oxazolidonedione Struktur

2224-52-4

CAS-Nr.: 2224-52-4

Bezeichnung:: (S)-4-Methyloxazolidin-2,5-dion

Englisch Name:: (S)-4-Methyl-2,5-oxazolidonedione

Synonyma:: ALA-NCA;L-Ala-NCA;L-Alanine N-Carbxy anhydride;(S)-4-METHYL-OXAZOLIDINE-2,5-DIONE;H-ALA-NCA;H-L-Ala-NCA;Alanine, NCA;L-Alanine NC;L-ALA-NCA(2224-52-4);Creatinine Impurity 3

CBNumber:: CB7180875

Summenformel:: C4H5NO3

Molgewicht:: 115.09

MOL-Datei:: 2224-52-4.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 137

(S)-4-Methyloxazolidin-2,5-dion Eigenschaften

Schmelzpunkt:: 92℃

alpha: +5.13°(25/D,c=6.4,dioxane)

Dichte: 1.296

storage temp.: Inert atmosphere,Store in freezer, under -20°C

Löslichkeit: DMSO (Very Slightly, Heated)

Aggregatzustand: Solid

pka: 9.38±0.40(Predicted)

Farbe: White to Off-White

InChI: InChI=1S/C4H5NO3/c1-2-3(6)8-4(7)5-2/h2H,1H3,(H,5,7)/t2-/m0/s1

InChIKey: DTETYCNJKAUROO-REOHCLBHSA-N

SMILES: O1C(=O)[C@H](C)NC1=O

Sicherheit

Risiko- und Sicherheitserklärung
Gefahreninformationscode (GHS)

HS Code	2934999090

Bildanzeige (GHS)

Alarmwort

Warnung

Gefahrenhinweise

Code	Gefahrenhinweise	Gefahrenklasse	Abteilung	Alarmwort	Symbol	P-Code
H302	Gesundheitsschädlich bei Verschlucken.	Akute Toxizität oral	Kategorie 4	Warnung	src="/GHS07.jpg" width="20" height="20" />	P264, P270, P301+P312, P330, P501
H315	Verursacht Hautreizungen.	Hautreizung	Kategorie 2	Warnung	src="/GHS07.jpg" width="20" height="20" />	P264, P280, P302+P352, P321,P332+P313, P362
H319	Verursacht schwere Augenreizung.	Schwere Augenreizung	Kategorie 2	Warnung	src="/GHS07.jpg" width="20" height="20" />	P264, P280, P305+P351+P338,P337+P313P
H332	Gesundheitsschädlich bei Einatmen.	Akute Toxizität inhalativ	Kategorie 4	Warnung	src="/GHS07.jpg" width="20" height="20" />	P261, P271, P304+P340, P312
H335	Kann die Atemwege reizen.	Spezifische Zielorgan-Toxizität (einmalige Exposition)	Kategorie 3 (Atemwegsreizung)	Warnung	src="/GHS07.jpg" width="20" height="20" />

Sicherheit

P261	Einatmen von Staub vermeiden.
P280	Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P305+P351+P338	BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

(S)-4-Methyloxazolidin-2,5-dion Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

(S)-4-Methyl-2,5-oxazolidonedione is composed of oxazolidine ring and 2,5-dione ring. It exhibits chirality, meaning it exists as two non-superimposable mirror image forms. Therefore, it can be used as an organic reagent for the synthesis of enantiomeric pure substances. (S)-4-Methyl-2,5-oxazolidonedione is a reagent used in the synthesis of poly(γ-benzyl-L-glutamate) and its block polypeptides with alanine, leucine and phenylalanine.

Vorbereitung Methode

L-alanine (20.0 g, 0.224 mol) and triphosgene (53.4 g, 0.180 mol) were suspended in 400.0 mL of dry THF bubbled with nitrogen flux in a flame-dried three-neck flask. The mixture was stirred at 60 °C for 2 h before further bubbling with nitrogen flux for 30 min. After that, the solution was precipitated in 1000.0 mL of n-hexane and stored at -20 °C. The supernatant was removed, and the residues were collected and dissolved in 200.0 mL of ethyl acetate, before two washings with 100.0mL of ice-cold water and one washing with 100.0 mL of 0.5% NaHCO3 ice-cold aqueous solution. The organic phase was then dried over anhydrous MgSO4 and evaporated to obtain 15.5 g of L-Ala NCA ((S)-4-Methyl-2,5-oxazolidonedione). The yield of L-Ala NCA was 77.5%.

Synthesis Reference(s)

The Journal of Organic Chemistry, 50, p. 2200, 1985 DOI: 10.1021/jo00212a042

(S)-4-Methyloxazolidin-2,5-dion Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Di-tert-butyl Tricarbonate N-[(1,1-Dimethylethoxy)carbonyl]-L-alanin L-Alanine, N-(methoxycarbonyl)- (9CI) N-Benzyloxycarbonyl-L-alanin L-Alanin Bis(trichlormethyl)carbonat Trichlormethan Trichlormethylchlorformiat

Downstream Produkte

1-L-Alanyl-L-prolin

(S)-4-Methyloxazolidin-2,5-dion Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 137)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Sichuan HongRi Pharma-Tech Co.,Ltd	+86-028-64841719 +8617390183901	daisy@enlaibio.com	China	1106	58
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	18648	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21639	55
Hangzhou FandaChem Co.,Ltd.	+8615858145714	FandaChem@Gmail.com	China	9220	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32820	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29886	58
Sichuan Jiaying Lai Technology Co.,LTD	18716376478	ycling@enlaibio.com	CHINA	302	58
Changzhou Carman Chemical Co., Ltd.	15061933924		CHINA	514	58
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	sales@chemdad.com	China	39894	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58

2224-52-4((S)-4-Methyloxazolidin-2,5-dion)Verwandte Suche:

N-3,5-Dichlorphenyl-5-methyl-5-vinyl-1,3-oxazolidin-2,4-dion 4-[(4-Hydroxyphenyl)methyl]oxazolidin-2,5-dion 4-Methyloxazolidin-2,5-dion

(S)-4-METHYL-2,5-OXAZOLIDINEDIONE
(S)-4-Methyl-2,5-oxazolidonedione
H-ALA-NCA
Alanine, NCA
N-Carboxy-L-alanine anhydride
4-methyl-1,3-oxazolidine-2,5-dione
4-methyloxazolidine-2,5-quinone
N-Carboxyalanine Anhydride
(4S)-4-Methyl-1,3-oxazolidine-2,5-dione
2,5-Oxazolidinedione,4-Methyl-, (4S)-
(4S)-4-Methyloxazolidine-2,5-dione
L-Alanine NC
L-ALA-NCA(2224-52-4)
(S)-4-METHYL-OXAZOLIDINE-2,5-DIONE
L-Alanine N-Carbxy anhydride
ALA-NCA
L-Ala-NCA
L-Ala-N-Carboxyanhydride
Alanine N-carboxyanhydride
Creatinine Impurity 3
Sodium Phenylbutyrate Impurity 4
L-alanine-n-carboxylic intracyclic anhydride
H-L-Ala-NCA
2224-52-4
AMINOACIDS DERIVATIVES