Gemcitabine hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R21:Gesundheitsschädlich bei Berührung mit der Haut.
R36/38:Reizt die Augen und die Haut.
R46:Kann vererbbare Schäden verursachen.
R62:Kann möglicherweise die Fortpflanzungsfähigkeit beeinträchtigen.
R63:Kann das Kind im Mutterleib möglicherweise schädigen.
S-Sätze Betriebsanweisung:
S25:Berührung mit den Augen vermeiden.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
Beschreibung
Gemcitabine is a novel nucleoside analog that was launched in 1995 in the
Netherlands for the treatment of non-small cell lung cancer (nsclc) and in Sweden for
pancreatic cancer. Gemcitabine is a prodrug which is phosphorylated intracellularly by
deoxycytadine kinase to its active forms, the di- and triphosphates which bind to DNA
competitively. This insertion inhibits processes required for DNA synthesis and
metabolism, the essential function for both cell replication and repair. Furthermore,
gemcitabine displays an extraordinary array of self-potentiating mechanisms that
increase the concentration and prolong the retention of its active nucleotides in tumor
cells. The title compound has shown activity against a wide spectrum of human solid
tumors including colon, mammary, breast, bladder cancers. Synergistic activity of
gemcitabine with other anticancer agents such as cisplatin has been reported.
Chemische Eigenschaften
White crystalline granular, odorless
Definition
ChEBI: A 2'-deoxycytidine hydrochloriode having geminal fluoro substituents in the 2'-position. An inhibitor of ribonucleotide reductase, gemcitabine hydrochloride is used in the treatment of various carcinomas, including non-small cell lung cancer, pancreatic ca
cer, bladder cancer and breast cancer.
Biologische Aktivität
Deoxycytidine analog that inhibits DNA synthesis. Metabolized to form gemcitabine triphosphate (dFdCTP) and gemcitabine diphosphate (dFdCDP). dFdCTD inhibits ribonucleotide reductase causing a reduction in cellular nucleotides. dFdCTP is incorporated in DNA resulting in DNA strand termination. Displays antitumor activity in vitro and in vivo .
Gemcitabine hydrochloride Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
