WORTMANNIN

WORTMANNIN Struktur
19545-26-7
CAS-Nr.
19545-26-7
Englisch Name:
WORTMANNIN
Synonyma:
CS-731;KY 1242;sl-2052;KY 12420;WORTMANNIN;Wortmammin;Wortmannin,98%;WORTMANNINTOXIN;SL-2052;KY-12420;antibioticsl-2052
CBNumber:
CB7241293
Summenformel:
C23H24O8
Molgewicht:
428.43
MOL-Datei:
19545-26-7.mol

WORTMANNIN Eigenschaften

Schmelzpunkt:
234-240 °C
alpha 
+80.0~+105.0゜(20℃/D)(c=0.1,C2H5OH)
Siedepunkt:
463.31°C (rough estimate)
Dichte
1.2454 (rough estimate)
Brechungsindex
1.4480 (estimate)
Flammpunkt:
2℃
storage temp. 
-20°C
Löslichkeit
DMSO: soluble
Aggregatzustand
powder
Farbe
off-white
Sensitive 
Light Sensitive
maximale Wellenlänge (λmax)
296nm(lit.)
Merck 
14,10053
BRN 
67676
Stabilität:
Stable for 1 year from date of purchase as supplied. Dried aliquots evaporated from ethanol may be stored at -20° for several months. Solutions however are not stable and must be used within one working day. Note

Sicherheit

Kennzeichnung gefährlicher T+,T,Xi,Xn,F
R-Sätze: 26/27/28-36/37/38-36-20/21/22-11
S-Sätze: 28-36/37-45-37/39-26-16
RIDADR  UN 3462 6.1/PG 1
WGK Germany  3
RTECS-Nr. CB9641000
3-8-10
HazardClass  6.1
PackingGroup  I
HS Code  29322090

WORTMANNIN Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R26/27/28:Sehr giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-Sätze Betriebsanweisung:

S28:Bei Berührung mit der Haut sofort abwaschen mit viel . . . (vom Hersteller anzugeben).
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.

Chemische Eigenschaften

White to pale yellow powder

Verwenden

Wortmannin is a steroidal metabolite belonging to the viridin group, isolated from Penicillium wortmannii in 1957. The structure was finally solved in 1968. Wortmannin exhibits broad spectrum antifungal activity, together with antitumour and antiinflammatory activity. Wortmannin is a potent inhibitor of phosphoinositide 3-kinase and myosin light chain kinase. Wortmannin also activates neutrophil and formyl-Met-Leu-Phe-mediated phospholipase D, inhibits autophagy, potentiates LPS-induced NO production and induces Alzheimer-like hyperphosphorylation in tau in vivo.

Biologische Aktivität

Potent, selective, cell-permeable and irreversible inhibitor of phosphatidylinositol 3-kinase (PI 3-kinase) (IC 50 = 2-4 nM). Also potently inhibits polo-like kinase 1 (PLK1) (IC 50 = 5.8 nM).

WORTMANNIN Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


WORTMANNIN Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 215)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 32957 60
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29880 58
Chongqing Chemdad Co., Ltd
+86-023-6139-8061 +86-86-13650506873
sales@chemdad.com China 39894 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32161 58
Hubei Ipure Biology Co., Ltd
+8613367258412
ada@ipurechemical.com China 10319 58
HONG KONG IPURE BIOLOGY CO.,LIMITED
86 18062405514 18062405514
ada@ipurechemical.com CHINA 3461 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
86-571-88216897,88216896 13588875226
sales@hzclap.com CHINA 6312 58
Shaanxi Dideu Medichem Co. Ltd
+86-029-89586680 +86-18192503167
1026@dideu.com China 7724 58
Zhejiang J&C Biological Technology Co.,Limited
+1-2135480471 +1-2135480471
sales@sarms4muscle.com China 10473 58
InvivoChem
+1-708-310-1919 +1-13798911105
sales@invivochem.cn United States 6391 58

19545-26-7()Verwandte Suche:


  • antibioticsl-2052
  • sl-2052
  • [1S-(1ALPHA,6BALPHA,9ABETA,11ALPHA,11BBETA)]-11-(ACETYLOXY)-1,6B,7,8,9A,10,11,11B-OCTAHYDRO-1-(METHOXYMETHYL)-9A,11B-DIMETHYL-3H-FURO[4,3,2-DE]INDENO[4,5-H]-2-BENZOPYRAN-3,6,9-TRIONE
  • KY 1242
  • 3H-Furo[4,3,2-de]indeno[4,5-h]-2-benzopyran-3,6,9-trione,11-(acetyloxy)-1,6b,7,8,9a,10,11,11b-octahydro-1-(methoxymethyl)-9a,11b-dimethyl-,(1S,6bR,9aS,11R,11bR)-
  • Wortmannin KY 1242
  • Wortmannin (+)-Wortmannin
  • Wortmannin, Ready Made Solution
  • Wortmannin solution
  • Wortmannin, Penicillium funiculosum
  • (1S,6BR,9aS,11R,11bR)-1-(methoxymethyl)-9a,11b-dimethyl-3,6,9-trioxo-3,6,6b,7,8,9,9a,10,11,11b
  • (1S,6BR,9AS,11R,11BR) 11-(ACETYLOXY)-1,6B,7,8,9A,10,11,11B-OCTAHYDRO-1-(METHOXYMETHYL)-9A,11B-DIMETHYL-3H-FURO[4,3,2-DE]INDENO[[4,5-H]-2-H]-2-BENZOPYRAN-3,6,9-TRIONE
  • WORTMANNIN FROM PENICILLIUM FUMICULOSUM
  • KY 12420
  • PI 3-KINASE INHIBITOR
  • WORTMANNIN, PENICILLIUM WORTMANNI
  • WORTMANNIN
  • Wortmannin,Penicilliumwortmannin
  • 3H-Furo[4,3,2-de]indeno[4,5-h]-2-benzopyran-3,6,9-trione, 11-(acetyloxy)-1,6b,7,8,9a,10,11,11b-octahydro-1-(methoxymethyl)-9a,11b-dimethyl-, (1S,6bR,9aS,11R,11bR)- (9CI)
  • WORTMANNINTOXIN
  • WORTMANNIN, FROM PENICILLIUM FUNICULOSUM
  • (1S,6br,9aS,11R,11bR) 11-(Acetyloxy)-1,6b,7,8,9a,10,11,11b-octahydro-1-(methoxymethyl)-9a,11b-dimethyl-3H-furo[4,3,2-de]indeno[4,5,-h]-2-h]-2-benzopyran-3,6,9-trione
  • (1S)-1,6bβ,7,8,9a,10,11,11b-Octahydro-11β-acetyloxy-1-(methoxymethyl)-9aα,11bα-dimethyl-3H-furo[4,3,2-de]indeno[4,5-h]-2-benzopyran-3,6,9-trione
  • Wortmannin,98%
  • Wortmammin
  • WORTMANNIN FROM PENICILLIUM FUMICULASUM
  • Wortmannin,KY 12420
  • WORTMANNINWORTMANN
  • CS-731
  • SL-2052;KY-12420
  • Wortmannin - CAS 19545-26-7 - Calbiochem
  • Wortmannin, a multi-target inhibitor of PI3K and MLCK
  • WORTMANNIN USP/EP/BP
  • (1S,6bR,9aS,11R,11bR)-1-(Methoxymethyl)-9a,11b-dimethyl-3,6,9-trioxo-1,6,6b,7,8,9,9a,10,11,11b-decahydro-3H-furo[4,3,2-de]indeno[4,5-h]isochromen-11-yl acetate
  • Wortmannin (SL-2052
  • Wortmannin from Talaromyces (Penicillium)
  • Wortmannin, 98%, a multi-target inhibitor of PI3K and MLCK
  • Wortmannin (99.5%)
  • Wortmannin (BR, 99%)
  • (1S,6bR,9aS,11R,11bR)-1-(methoxymethyl)-9a,11b-dimethyl-3,6,9-trioxo-3,6,6b,7,8,9,9a,10,11,11b-decahydro-1H-furo[4,3,2-de]indeno[4,5-h]isochromen-11-yl acetate
  • Wortmannin in Acetonitrile
  • 19545-26-7
  • C23H24O8
  • Enzymes, Inhibitors, and Substrates
  • Enzyme Inhibitors by Type
  • Enzyme Inhibitors
  • Kinase/Phosphatase Biology
  • Serine/Threonine Kinase Inhibitors
  • Phosphatidylinositol 3-kinase (PI3K)
  • Other
  • Cell Signaling and Neuroscience
  • Cell Biology
  • Biochemicals and Reagents
  • BioChemical
  • Anti-cancer&immunity
  • inhibitor
  • Inhibitors
  • Signalling
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