7-CHLORO-5-(2-CHLOROPHENYL)-1,5-DIHYDRO-4,1-BENZOTHIAZEPIN-2(3H)-ONE
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- CAS-Nr.
- 75450-34-9
- Englisch Name:
- 7-CHLORO-5-(2-CHLOROPHENYL)-1,5-DIHYDRO-4,1-BENZOTHIAZEPIN-2(3H)-ONE
- Synonyma:
- CGP 37157;1-benzothiazepine-2(3H)-one;7-Chloro-5-(2-chlorophenyl)-1;CGP-37157 - CAS 75450-34-9 - Calbiochem;CGP 37157,CGP37157,Inhibitor,CGP-37157,inhibit,Na+/Ca2+ Exchanger;7-chloro-5-(2-chlorophenyl)benzo[e][1,4]thiazepin-2(1H,3H,5H)-one;7-CHLORO-5-(2-CHLOROPHENYL)-1,5-DIHYDRO-4,1-BENZOTHIAZEPIN-2(3H)-ONE;7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepine-2(3H)-one;4,1-Benzothiazepin-2(3H)-one, 7-chloro-5-(2-chlorophenyl)-1,5-dihydro-;7-Chloro-5-(2-chlorophenyl)-3,5-dihydrobenzo[e][1,4]thiazepin-2(1H)-one
- CBNumber:
- CB7314153
- Summenformel:
- C15H11Cl2NOS
- Molgewicht:
- 324.22
- MOL-Datei:
- 75450-34-9.mol
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7-CHLORO-5-(2-CHLOROPHENYL)-1,5-DIHYDRO-4,1-BENZOTHIAZEPIN-2(3H)-ONE Eigenschaften
- Siedepunkt:
- 479.8±45.0 °C(Predicted)
- Dichte
- 1.384±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- Löslichkeit
- DMSO: ≥20mg/mL
- pka
- 12.20±0.40(Predicted)
- Aggregatzustand
- White solid
- Farbe
- white
- Stabilität:
- Stable for 2 years from date of purchase as supplied. Solution in DMSO may be stored at -20°C for up to 3 months.
7-CHLORO-5-(2-CHLOROPHENYL)-1,5-DIHYDRO-4,1-BENZOTHIAZEPIN-2(3H)-ONE Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one is a specific inhibitor of the mitochondrial Na+/Ca2+ exchanger.
Allgemeine Beschreibung
CGP-37157 is a benzothiazepine compound, which is derived from clonazepam. It functions as a sarco/endoplasmic reticulum Ca
2+ ATPase (SERCA) antagonist and ryanodine receptor channels (RyR) agonist. CGP-37157 regulates intracellular signaling of calcium in smooth, cardiac and skeletal muscle cells and non-muscle systems.
Biologische Aktivität
Selective antagonist of the mitochondrial Na + -Ca 2+ exchanger (IC 50 = 0.4 μ M).
7-CHLORO-5-(2-CHLOROPHENYL)-1,5-DIHYDRO-4,1-BENZOTHIAZEPIN-2(3H)-ONE Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
7-CHLORO-5-(2-CHLOROPHENYL)-1,5-DIHYDRO-4,1-BENZOTHIAZEPIN-2(3H)-ONE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 79)Lieferanten
75450-34-9()Verwandte Suche:
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- 7-CHLORO-5-(2-CHLOROPHENYL)-1,5-DIHYDRO-4,1-BENZOTHIAZEPIN-2(3H)-ONE
- CGP 37157
- 7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepine-2(3H)-one
- 4,1-Benzothiazepin-2(3H)-one, 7-chloro-5-(2-chlorophenyl)-1,5-dihydro-
- 7-chloro-5-(2-chlorophenyl)benzo[e][1,4]thiazepin-2(1H,3H,5H)-one
- CGP-37157 - CAS 75450-34-9 - Calbiochem
- 1-benzothiazepine-2(3H)-one
- 7-Chloro-5-(2-chlorophenyl)-1
- 7-Chloro-5-(2-chlorophenyl)-3,5-dihydrobenzo[e][1,4]thiazepin-2(1H)-one
- CGP 37157,CGP37157,Inhibitor,CGP-37157,inhibit,Na+/Ca2+ Exchanger
- 75450-34-9
- C15H12ClNOS
- Ion transporter and other ion channel
- Signalling