POMALIDOMIDE-C9-CO2H

2243000-24-8

CAS-Nr.: 2243000-24-8

Englisch Name:: POMALIDOMIDE-C9-CO2H

Synonyma:: Pomalidomide-C?-CO?H;Pomalidomide-C9-COOH;POMALIDOMIDE-C9-CO2H;Thalidomide-4-NH-C9-COOH;10-[[2-(2,6-Dioxo-3-piperidyl)-1,3-dioxoisoindolin-4-yl]amino]decanoic Acid;10-[(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl)amino]decanoic acid;Decanoic acid, 10-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-;10-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)decanoic acid, Crosslinker?E3 Ligase ligand conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader

CBNumber:: CB74740493

Summenformel:: C23H29N3O6

Molgewicht:: 443.49

MOL-Datei:: 2243000-24-8.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 13

POMALIDOMIDE-C9-CO2H Eigenschaften

Siedepunkt:: 714.1±55.0 °C(Predicted)

Dichte: 1.326±0.06 g/cm3(Predicted)

storage temp.: 2-8°C

Aggregatzustand: powder or crystals

pka: 4.78±0.10(Predicted)

Sicherheit

POMALIDOMIDE-C9-CO2H Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Protein degrader builiding block Pomalidomide-C₉-CO₂H enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and an alkyl-chain crosslinker with pendant carboxylic acid for reactivity with an amine on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant carboxyl group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

POMALIDOMIDE-C9-CO2H Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

POMALIDOMIDE-C9-CO2H Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 13)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58
Xian confluore Biological Technology Co., Ltd.	+86-15680926068 +86-15680926068	1924344760@confluore.cn	China	2996	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52927	58
Daicel Chiral Technologies (China)CO.,LTD	021-50460086-9 15921403865	han_yajun@dctc.daicel.com	China	6943	65
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80
Shanghai Chaolan Chemical Technology Center	QQ:65489617 15618227136	info@SuperLan-chem.com	China	9863	58
Xi'an Confluore Biological Technology Co., Ltd.	+86-156-80926068 +86-15680926068	1924344760@qq.com	China	4824	58
Jilin Province Woda Biotechnology Co., Ltd.	13504435624	1927928688@qq.com	China	1366	58
Changzhou Bojia Biomedical Technology Co., Ltd.	2122619822	czbjpharma@126.com	China	18488	58

POMALIDOMIDE-C9-CO2H
Pomalidomide-C9-COOH
Decanoic acid, 10-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-
10-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)decanoic acid, Crosslinker?E3 Ligase ligand conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader
Thalidomide-4-NH-C9-COOH
10-[[2-(2,6-Dioxo-3-piperidyl)-1,3-dioxoisoindolin-4-yl]amino]decanoic Acid
Pomalidomide-C?-CO?H
10-[(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl)amino]decanoic acid
2243000-24-8