4-(5H-Dibenzo(a,d)cyclohepten-5-yliden)-1-methyl-piperidin
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- CAS-Nr.
- 129-03-3
- Bezeichnung:
- 4-(5H-Dibenzo(a,d)cyclohepten-5-yliden)-1-methyl-piperidin
- Englisch Name:
- Cyproheptadine
- Synonyma:
- Periactin;MK 141;Dronactin;Periactine;Periactinol;Cypoheptadine;AKOS NCG1-0040;CYPROHEPTADINE;Eiproheptadine;Cycloheptadine
- CBNumber:
- CB7782550
- Summenformel:
- C21H21N
- Molgewicht:
- 287.4
- MOL-Datei:
- 129-03-3.mol
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4-(5H-Dibenzo(a,d)cyclohepten-5-yliden)-1-methyl-piperidin Eigenschaften
- Schmelzpunkt:
- 112.3-113.3°
- Siedepunkt:
- 419.7°C (rough estimate)
- Dichte
- 0.9917 (rough estimate)
- Brechungsindex
- 1.8240 (estimate)
- storage temp.
- Store at -20°C
- Aggregatzustand
- Solid
- pka
- pKa 8.87 (Uncertain)
- Farbe
- Crystals from EtOH (aq)
- Wasserlöslichkeit
- 317.6ug/L(22.5 ºC)
- CAS Datenbank
- 129-03-3(CAS DataBase Reference)
- NIST chemische Informationen
- Cyproheptadine(129-03-3)
4-(5H-Dibenzo(a,d)cyclohepten-5-yliden)-1-methyl-piperidin Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Cyproheptadine has antianaphylactic activity that is associated with its ability to slow
down the release of histamine and other mediators from fat cells.
Verwenden
Antihistaminic; antipruritic.
Definition
ChEBI: The product resulting from the formal oxidative coupling of position 5 of 5H-dibenzo[a,d]cycloheptene with position 4 of 1-methylpiperidine resulting in the formation of a double bond between the two fragments.
t is a sedating antihistamine with antimuscarinic and calcium-channel blocking actions. It is used (particularly as the hydrochloride sesquihydrate) for the relief of allergic conditions including rhinitis, conjunctivitis due to inhalant allergens and food
, urticaria and angioedema, and in pruritic skin disorders. Unlike other antihistamines, it is also a seratonin receptor antagonist, making it useful in conditions such as vascular headache and anorexia.
Weltgesundheitsorganisation (WHO)
Cyproheptadine, an antihistamine with anticholinergic and
serotonin-antagonist properties, was introduced in 1961 for the symptomatic relief
of allergy and was subsequently used as an appetite stimulant. In 1982 the drug
was prohibited in Bangladesh because of its misuse as an appetite stimulant due
to inappropriate promotion. Cyproheptadine remains widely available and the
current marketing policy of the major manufacturer requires that it should be used
as an appetite stimulant only under the supervision of a physician who should be
assured that adequate food is available.
Sicherheitsprofil
Poison by ingestion, intraperitoneal, subcutaneous and intravenous routes. Experimental teratogenic and reproductive effects. When heated to decomposition it emits toxic fumes of NOx.
4-(5H-Dibenzo(a,d)cyclohepten-5-yliden)-1-methyl-piperidin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
4-(5H-Dibenzo(a,d)cyclohepten-5-yliden)-1-methyl-piperidin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 64)Lieferanten
129-03-3(4-(5H-Dibenzo(a,d)cyclohepten-5-yliden)-1-methyl-piperidin)Verwandte Suche:
- 1-Methyl-4-(5H-dibenzo[a,d]cycloheptenylidene)piperidine
- Cypoheptadine
- Cyproheptadiene
- Dronactin
- Eiproheptadine
- MK 141
- Periactine
- Periactinol
- Piperidine, 4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-methyl-
- CYPROHEPTADINE
- AKOS NCG1-0040
- 4-dibenzo(a,d)cycloepten-5-ylidene-1-methylpiperidine
- 5-[1-Methylpiperidylidene-4]-[5H]-dibenzo [a,d] cycloheptene
- DIBENZOSUBERONONE /CYPROHEPTADINE
- 1-Methyl-4-(dibenzo[a,e]cycloheptatrien-5-ylidene)piperidine
- 4-(5H-dibenzo[a,d][7]annulen-5-ylidene)-1-methylpiperidine
- Cycloheptadine
- TIANFUCHEM--129-03-3--Cyproheptadine in stock
- Periactin
- Cyproheptadine HCl IP/BP/Ph. Eur /USP
- Cyproheptadine in methanol
- 129-03-3
