(+)-3-(3,4-Dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexan-3-carbonitril

(+)-3-(3,4-dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexane-3-carbonitrile Struktur

38321-02-7

CAS-Nr.: 38321-02-7

Bezeichnung:: (+)-3-(3,4-Dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexan-3-carbonitril

Englisch Name:: (+)-3-(3,4-dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexane-3-carbonitrile

Synonyma:: d-Verapamil;Dexverapami;Dexverapamil;Dexverapamil Hydrochloride;[R,(+)]-2-(3,4-Dimethoxyphenyl)-2-isopropyl-5-(N-methyl-3,4-dimethoxyphenethylamino)valeronitrile;(R)-α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl)benzeneacetonitrile;(aR)-a-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-a-(1-methylethyl)-benzeneacetonitrile;(αR)-α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl](methyl)amino]propyl]-3,4-dimethoxy-α-(1-methylethyl)benzeneacetonitrile;Benzeneacetonitrile, a-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-a-(1-methylethyl)-, (R)-;Benzeneacetonitrile, α-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl)-, (αR)-

CBNumber:: CB7941337

Summenformel:: C27H38N2O4

Molgewicht:: 454.61

MOL-Datei:: 38321-02-7.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 12

(+)-3-(3,4-Dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexan-3-carbonitril Eigenschaften

Schmelzpunkt:: 129-131°C

Siedepunkt:: 586.1±50.0 °C(Predicted)

Dichte: 1.058±0.06 g/cm3(Predicted)

pka: 8.97±0.50(Predicted)

Sicherheit

(+)-3-(3,4-Dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexan-3-carbonitril Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften

Off-White Solid

Verwenden

Both isomers inhibit the p-glycoprotein efflux pump in multidrug resistant tumor cells

Definition

ChEBI: A 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile that has R configuration. It competitively inhibits the multidrug resistance efflux pump P-glycoprotein (MDR-1, EC 3.6.3.44), thereby p tentially increasing the effectiveness of a wide range of antineoplastic drugs which are inactivated by MDR-1 mechanisms. Dexverapamil exhibits lower calcium antagonistic activity and toxicity than racemic verapamil.

(+)-3-(3,4-Dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexan-3-carbonitril Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

(+)-3-(3,4-Dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexan-3-carbonitril Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 12)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
LGM Pharma	1-(800)-881-8210	inquiries@lgmpharma.com	United States	2127	70
Clearsynth Labs Limited	+91-22-26355700	info@clearsynth.com	India	9685	58
Energy Chemical	021-58432009 400-005-6266	marketing@energy-chemical.com	China	44941	58
QUALITY CONTROL SOLUTIONS LTD.	13670046396	ORDERS@QCSRM.COM	China	18865	58
Changzhou Bojia Biomedical Technology Co., Ltd.	2122619822	czbjpharma@126.com	China	18488	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	28118	58

38321-02-7((+)-3-(3,4-Dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexan-3-carbonitril)Verwandte Suche:

Valeronitril Phenylacetonitril Verapamil 3,4-Dimethoxyphenylacetonitril 4-Hydroxy-3-methoxyphenylacetonitril (+)-3-(3,4-Dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexan-3-carbonitril Verapamilhydrochlorid 2-(3,4-Dimethoxyphenyl)-3-methylbutyronitril 3-(3,4-Dimethoxyphenyl)-2-methyl-6-methylaminohexan-3-carbonitril 5-[(3,4-Dimethoxyphenethyl)amino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitril

Dexverapamil
(aR)-a-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-a-(1-methylethyl)-benzeneacetonitrile
Dexverapami
Benzeneacetonitrile, a-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-a-(1-methylethyl)-, (aR)- (9CI)
Benzeneacetonitrile, a-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-a-(1-methylethyl)-, (R)-
d-Verapamil
(aR)-a-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-a-(1-methylethyl)-benzeneacetonitrile Hydrochloride
Dexverapamil Hydrochloride
(R)-α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl)benzeneacetonitrile
(αR)-α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl](methyl)amino]propyl]-3,4-dimethoxy-α-(1-methylethyl)benzeneacetonitrile
[R,(+)]-2-(3,4-Dimethoxyphenyl)-2-isopropyl-5-(N-methyl-3,4-dimethoxyphenethylamino)valeronitrile
Benzeneacetonitrile, α-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl)-, (αR)-
38321-02-7
C27H39ClN2O4
Intermediates & Fine Chemicals
Pharmaceuticals