methyl 2-fluoro-3-nitrobenzoate

methyl 2-fluoro-3-nitrobenzoate Struktur
946126-94-9
CAS-Nr.
946126-94-9
Englisch Name:
methyl 2-fluoro-3-nitrobenzoate
Synonyma:
2-fluoro-3-nitrobenzoate;methyl 2-fluoro-3-nitrobenzoate;2-Fluoro-3-(methoxycarbonyl)nitrobenzene;Benzoic acid, 2-fluoro-3-nitro-, Methyl ester
CBNumber:
CB81553204
Summenformel:
C8H6FNO4
Molgewicht:
199.14
MOL-Datei:
946126-94-9.mol

methyl 2-fluoro-3-nitrobenzoate Eigenschaften

Schmelzpunkt:
77- 80° C
Siedepunkt:
310.8±27.0 °C(Predicted)
Dichte
1.388±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
Löslichkeit
Chloroform (Slightly), Methanol (Slightly)
Aggregatzustand
Solid
Farbe
Off-White to Pale Yellow
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
HS Code  2916310090
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

methyl 2-fluoro-3-nitrobenzoate Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Methyl 2-fluoro-3-nitrobenzoate can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development processes and chemical production processes.

Synthese

2.jpgA solution of 2-fluoro-3-nitrobenzoic acid (5 g, 27.0 mmol) in MeOH (50 mL) was treated with concentrated H2SO4 (1.4 mL, 27.0 mmol) and the resulting reaction was stirred at 50 °C for 16 h. The solvent was removed under reduced pressure and the residue was diluted with EtO Ac. The organic solution was washed with saturated aqueous NaHCO3 solution until the water phase reached neutral pH. The two phases were separated. Organics were washed with water, brine and dried (Na2SO4). The solution was filtered and concentrated to give crude methyl 2-fluoro-3-nitrobenzoate which was used as is in the next step. (5.1 g, 25.2 mmol, 93 %) as a pale yellow solid.

methyl 2-fluoro-3-nitrobenzoate Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


methyl 2-fluoro-3-nitrobenzoate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 164)Lieferanten
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  • methyl 2-fluoro-3-nitrobenzoate
  • Benzoic acid, 2-fluoro-3-nitro-, Methyl ester
  • 2-Fluoro-3-(methoxycarbonyl)nitrobenzene
  • 2-fluoro-3-nitrobenzoate
  • 946126-94-9
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