3-Oxo-N-[(3S)-tetrahydro-2-oxo-3-furanyl]dodecanamide
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- CAS-Nr.
- 168982-69-2
- Englisch Name:
- 3-Oxo-N-[(3S)-tetrahydro-2-oxo-3-furanyl]dodecanamide
- Synonyma:
- N-(3-OXODODECANOYL)-L-HOMOSERINE;3-oxo-N-[(3S)-2-oxooxolan-3-yl]dodecanamide;(S)-3-Oxo-N-(2-oxotetrahydrofuran-3-yl)dodecanamide;N-(3-oxododecanoyl)-L-homoserine lactone L-enantiomer;3-Oxo-N-[(3S)-tetrahydro-2-oxo-3-furanyl]dodecanamide;Dodecanamide, 3-oxo-N-[(3S)-tetrahydro-2-oxo-3-furanyl]-
- CBNumber:
- CB82489993
- Summenformel:
- C16H27NO4
- Molgewicht:
- 297.39
- MOL-Datei:
- 168982-69-2.mol
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3-Oxo-N-[(3S)-tetrahydro-2-oxo-3-furanyl]dodecanamide Eigenschaften
- Schmelzpunkt:
- 80-81 °C
- Siedepunkt:
- 519.4±50.0 °C(Predicted)
- Dichte
- 1.06
- storage temp.
- -20°C
- Löslichkeit
- ≤20mg/ml in DMSO;20mg/ml in dimethyl formamide
- Aggregatzustand
- crystalline solid
- pka
- 11.22±0.46(Predicted)
- Farbe
- White to light yellow
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizität (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen. |
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3-Oxo-N-[(3S)-tetrahydro-2-oxo-3-furanyl]dodecanamide Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
N-3-oxo-dodecanoyl-L-Homoserine lactone (3-oxo-C12-HSL) is a bacterial quorum-sensing signaling molecule produced by
P. aeruginosa and strains of the
B. cepacia complex. It induces the production of IL-8 in 16HBE human bronchial epithelial cells when used at a concentration of 100 μM. Supernatants from 3-oxo-C12-HSL-stimulated 16HBE cells induce chemotaxis of isolated human neutrophils. 3-oxo-C12-HSL has been found in respiratory secretions from patients with cystic fibrosis infected with
P. aeruginosa.
Verwenden
N-(3-Oxododecanoyl)-L-homoserine Lactone is a bacterial quorum sensing signal molecule. Inhibits lymphocyte proliferation and TNF-α and IL-12 production by LPS-stimulated macrophages. Inhibits or promotes antibody production at high and low concentrations, respectively, in keyhole limpet hemocyanin (KLH)-stimulated spleen cells.
Biochem/physiol Actions
N-(3-oxododecanoyl)homoserine-L-lactone (3-oxo-C12-HSL) is among a group of homoserine lactones that includes: N-octanoyl-homoserine lactone (N-C8-HSL), N-(3-oxodecanoyl) homoserine-L-lactone (3-oxo-C10 HSL), N-(3-Oxotetradecanoyl)-L-homoserine lactone (3-oxo-C14-HSL, N-(3-hydroxydecanoyl)-L-homoserine lactone, and N-(3-hydroxyoctanoyl)-L-homoserine lactone involved in the processes of bacterial quorum sensing. These N-acyl-homoserine lactones are used to study the processes and mechanisms of bacterial quorum sensing.
3-Oxo-N-[(3S)-tetrahydro-2-oxo-3-furanyl]dodecanamide Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
3-Oxo-N-[(3S)-tetrahydro-2-oxo-3-furanyl]dodecanamide Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 39)Lieferanten
- 3-Oxo-N-[(3S)-tetrahydro-2-oxo-3-furanyl]dodecanamide
- N-(3-oxododecanoyl)-L-homoserine lactone L-enantiomer
- N-(3-OXODODECANOYL)-L-HOMOSERINE
- (S)-3-Oxo-N-(2-oxotetrahydrofuran-3-yl)dodecanamide
- Dodecanamide, 3-oxo-N-[(3S)-tetrahydro-2-oxo-3-furanyl]-
- 3-oxo-N-[(3S)-2-oxooxolan-3-yl]dodecanamide
- 168982-69-2
