MLL1 (human recombinant)

MLL1 (human recombinant) Struktur
CAS-Nr.
Englisch Name:
MLL1 (human recombinant)
Synonyma:
MLL1 (human recombinant)
CBNumber:
CB82591717
Summenformel:
Molgewicht:
0
MOL-Datei:
Mol file

MLL1 (human recombinant) Eigenschaften

Sicherheit

MLL1 (human recombinant) Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Mixed Lineage Leukemia (MLL1) plays a major role in epigenetic regulation through methylation of histone 3 at lysine 4 (H3K4) to activate gene transcription. Methylation of H3K4 leads to upregulation of developmental genes, including HOX family members. In addition to its methylation activity, MLL1 has been shown to co-localize with Pol II at several genomic elements. Consequently, MLL1 has very low basal methyltransferase activity unless complexed with the activating protein complex of WDR5, Ash2L, and RbBP5 (MLL/WAR complex). This C-terminal fragment of MLL1, residues 3762 - 3969, contains the SET1 domain for methyltransferase activity, and the WIN motif for binding the WAR complex. The protein DPY-30 has also been reported to associate with the MLL1-WAR complex. MLL1 is also available as a component of the MLL1/WAR complex and MLL1/WARD complex .

MLL1 (human recombinant) Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


MLL1 (human recombinant) Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 10)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767
sales@chemegen.com China 11289 58

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