Chinese english Germany Japanese Korea

SR 144528

SR 144528 Struktur
192703-06-3
CAS-Nr.
192703-06-3
Englisch Name:
SR 144528
Synonyma:
SR 144528;SR-144528,SR144528;5-(4-Chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-N-[(1S,2S,4R)-1,3,3-trimethylbicyclo[2.2.1]hept-2-yl]-1H-pyrazole-3-carboxamide;1H-Pyrazole-3-carboxamide, 5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-N-[(1S,2S,4R)-1,3,3-trimethylbicyclo[2.2.1]hept-2-yl]-
CBNumber:
CB82592587
Summenformel:
C29H34ClN3O
Molgewicht:
476.05
MOL-Datei:
192703-06-3.mol
Request For Quotation

SR 144528 Eigenschaften

Siedepunkt:
627.7±55.0 °C(Predicted)
Dichte
1.22±0.1 g/cm3(Predicted)
storage temp. 
-20°C
Löslichkeit
Soluble in DMSO (up to 20 mg/ml, with warming).
Aggregatzustand
powder
pka
11.52±0.60(Predicted)
Farbe
white to beige
Stabilität:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Sicherheit

RTECS-Nr. UQ6276700

SR 144528 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

SR 144528 is a cannabinoid (CB) receptor 2 inverse agonist with Ki values ranging from 0.3 to 5.6 nM. It is selective for CB2 over CB1 receptors, where it has Ki values ranging from 305 to >10,000 nM. SR 144528 blocks the inhibitory effects of CP 55,940 on forskolin-induced adenylyl cyclase activity in CHO cells expressing hCB2 (IC50 = 10 nM) but not in cells expressing hCB1 (IC50 = >10 μM). SR 144528 has been used to investigate the contribution of the CB2 receptor in the control of pain initiation as well as suppression of inflammation and immune activation.

Biochem/physiol Actions

SR144528 is a potent and highly selective cannabinoid CB2 receptor inverse agonist. SR144528 exhibited a Ki of 0.6 nM at CB2 compared to 400 nM at the related CB1 receptor.

SR 144528 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

SR 144528 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 69)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 19892 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695
 laboratory@coreychem.com China 30250 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226
 sales@hzclap.com CHINA 6313 58
Finetech Industry Limited 		+86-27-87465837 +8618971612321
 info@finetechnology-ind.com China 9641 58
Nantong HI-FUTURE Biology Co., Ltd. 		+undefined18051384581
 sales@chemhifuture.com China 3136 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525
 masar@topule.com China 8474 58
Shanghai Acmec Biochemical Technology Co., Ltd. 		+undefined18621343501
 product@acmec-e.com China 33350 58
Aladdin Scientific 		+1-+1(833)-552-7181
sales@aladdinsci.com United States 57511 58
Wuhan Jingkang en Biomedical Technology Co., Ltd 		+8613720134139
 orders@jknbiochem.com China 5225 58
Wuhan Topule +86-02787215551 +86-19945035818
 2936752263@qq.com China 8206 58

192703-06-3()Verwandte Suche:

Astemizol Palmidrol Gaboxadol
  • SR 144528
  • 5-(4-Chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-N-[(1S,2S,4R)-1,3,3-trimethylbicyclo[2.2.1]hept-2-yl]-1H-pyrazole-3-carboxamide
  • 1H-Pyrazole-3-carboxamide, 5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-N-[(1S,2S,4R)-1,3,3-trimethylbicyclo[2.2.1]hept-2-yl]-
  • SR-144528,SR144528
  • 192703-06-3
  • C29H34ClN3O
Copyright 2019 © ChemicalBook. All rights reserved