FOSTRIECIN SODIUM SALT
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- CAS-Nr.
- 87860-39-7
- Englisch Name:
- FOSTRIECIN SODIUM SALT
- Synonyma:
- FST;CL-920;FST344;FOSTRIECIN;PHOSPHOTRIENIN;ci920sodiumsalt;cl1565asodiumsalt;FOSTRIECIN SODIUM;FOSTRIECIN SODIUM SALT;antibioticci920sodiumsalt
- CBNumber:
- CB8295127
- Summenformel:
- C19H28NaO9P
- Molgewicht:
- 454.39
- MOL-Datei:
- 87860-39-7.mol
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FOSTRIECIN SODIUM SALT Eigenschaften
- storage temp.
- -20°C
- Löslichkeit
- Soluble in H2O
- Aggregatzustand
- Colorless solid
- Wasserlöslichkeit
- Soluble to 100 mM in water
- InChIKey
- GMNLFZGMQHSFFV-DSXPUHJBNA-N
- SMILES
- [C@@H](OP(O)(O)=O)(C[C@@H](O)/C=C\C=C/C=C/CO)[C@@](O)(C)/C=C/[C@H]1CC=CC(=O)O1.[NaH] |&1:0,7,17,22,r|
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| WGK Germany |
3 |
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| RTECS-Nr. |
UQ0600000 |
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| Bildanzeige (GHS) |
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| Alarmwort |
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H402 |
Harmful to aquatic life |
Hazardous to the aquatic environment, acute hazard |
Category 3 |
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| Sicherheit |
| P273 |
Freisetzung in die Umwelt vermeiden. |
| P501 |
Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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FOSTRIECIN SODIUM SALT Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Fostriecin is an inhibitor of the serine/threonine protein phosphatases 2A (PP2A) and 4 (PP4) (IC
50s = 3.2 and 3 nM, respectively). It less effectively inhibits topoisomerase II and PP1 (IC
50s = 40 and 131 μM, respectively) and does not inhibit PP2B. Through its effects on protein phosphatases, fostriecin increases the level of histone H3 phosphorylation and may alter epigenetic regulation of cell proliferation. On a related note, fostriecin was first identified as an antitumor antibiotic.
Verwenden
Antineoplastic. Fostriecin is a Topo II, PP1, and PP2A inhibitor.
Biologische Aktivität
Originally identified as an antitumor antibiotic from Streptomyces pulveraceous . Displays potent inhibition of protein phosphatase types 2A (PP2A) and 4 (PP4) with IC 50 values of 1.5 nM and 3 nM respectively. Also exhibits weaker inhibition of topoisomerase II (IC 50 = 40 μ M) and protein phosphatase type 1 (PP1) (IC 50 = 131 μ M) with no apparent inhibition of protein phosphatase type 2B (PP2B). Active in vivo .
FOSTRIECIN SODIUM SALT Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
FOSTRIECIN SODIUM SALT Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 63)Lieferanten
87860-39-7()Verwandte Suche:
- 11-tridecatetraenyl)-monosodiumsalt
- antibioticci920sodiumsalt
- antibioticcl1565asodiumsalt
- ci920sodiumsalt
- cl1565asodiumsalt
- PHOSPHOTRIENIN
- fostriecin sodium salt from streptomyces pulveraceus
- FST
- FOSTRIECIN
- FOSTRIECIN SODIUM
- FOSTRIECIN SODIUM SALT
- FOSTRIECIN, SODIUM SALT, STREPTOMYCES PULVERACEOUS
- CL-920
- (6R)-5,6-DIHYDRO-6-[(1E,3R,4R,6R,7Z,9Z,11E)-3,6,13-TRIHYDROXY-3-METHYL-4-(PHOSPHONOOXY)-1,7,9,11-TRIDECATETRAENYL]-2H-PYRAN-2-ONE SODIUM SALT
- (6R)-5,6-Dihydro-6-[(1E,3R,4R,6R,7Z,9Z,11E)-3,6,13-trihydroxy-3-methyl-4-(phosphonooxy)-1,7,9,11-tridecatetraenyl]-2H-pyran-2-onesodiumsalt
- (6R)-5,6-Dihydro-6-[(1E,3R,4R,6R,7Z,9Z,11E)-3,6,13-trihydroxy-3-methyl-4-(phosphonooxy)-1,7,9,11-tridecatetraenyl]-2H-pyran-2-one monosodium salt
- Fostriecin, Sodium Salt, Streptomyces pulveraceous - CAS 87860-39-7 - Calbiochem
- FST344
- Fostriecin sodium salt from Streptomyces pulveraceus >=98% (HPLC)
- Human FST Protein, Fc Tag
- FOSTRIECIN SODIUM SALT USP/EP/BP
- 87860-39-7
- C19H27O9P
- C19H26O9PNa
- BioChemical
- Cell Signaling and Neuroscience
- Cell Biology
- Kinase/Phosphatase Biology
- Protein Phosphatase 2 (PP2)
- Serine/Threonine Phosphatase Inhibitors
- Active Pharmaceutical Ingredients
- FST
