InSolution Rapamycin - Calbiochem Chemische Eigenschaften,Einsatz,Produktion Methoden
Allgemeine Beschreibung
Selectively inhibits the phosphorylation and activation of p70 S6 kinase (IC
50 = 50 pM). Prevents the translational activation of IGF-II. Also prevents resting T-cells from entering the cell cycle, but does not directly arrest cell cycle progression. Shown to inhibit later signaling events, such as p110Rb phosphorylation, p34cdc2 kinase activation, and cyclin A synthesis. Exhibits strong binding to FK-506 binding proteins. Also reported to induce apoptosis in a murine B-cell line, to inhibit lymphokine-induced cell proliferation at the G
1 phase, and to irreversibly arrest
Saccharomyces cerevisiae cells in the G
1 phase.
Biochem/physiol Actions
Primary TargetMammalian target of rapamycin (mTOR)
InSolution Rapamycin - Calbiochem Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte